Review
Food Science & Technology
Aqsa Akhtar, Sadia Aslam, Sipper Khan, David Julian McClements, Nauman Khalid, Sajid Maqsood
Summary: Increasing consumer awareness of health and nutrition has driven the demand for nutraceuticals and functional foods containing bioactive compounds (BACs) with potential health benefits. However, the direct incorporation of many BACs into commercial food and beverage products is challenging due to their poor compatibility, instability, low bioavailability, or negative impact on food quality. Advanced encapsulation technologies, such as protein-based micro and nano-particles, have been developed to overcome these obstacles. This review discusses different methods for fabricating protein-based delivery systems, their compatibility, and the challenges and limitations associated with using various protein matrices. The fabrication methods include injection-gelation, controlled denaturation, and antisolvent precipitation. These protein-based particles can be used in a wide range of applications due to their different compositions, sizes, surface hydrophobicity, and electrical characteristics.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Lu Tang, Jing Li, Qingqing Zhao, Ting Pan, Hui Zhong, Wei Wang
Summary: Nanotechnology plays a crucial role in cancer treatment, improving drug delivery efficiency and pharmacokinetics. Small molecule drugs and biological macromolecule drugs are the main types of anticancer agents, with nano-encapsulation technology playing a key role in their delivery.
Article
Pharmacology & Pharmacy
Abdulrahman Alshadidi, Ahmad Abdul-Wahhab Shahba, Ibrahim Sales, Md Abdur Rashid, Mohsin Kazi
Summary: The current study developed a novel solid oral dosage form of lansoprazole and curcumin using bioactive self-nanoemulsifying drug delivery systems. The solid SNEDDS showed improved dissolution efficiency and stability, making it a potential combination therapy for the treatment of peptic ulcers.
Article
Nanoscience & Nanotechnology
Felipe da Silva Feltrin, Natalia Aimee D'Angelo, Joao Paulo de Oliveira Guarnieri, Andre Moreni Lopes, Marcelo Lancellotti, Liliane Maria Ferrareso Lona
Summary: This study evaluated the impact of pH, temperature, light exposure, and inert atmosphere on the encapsulation of curcumin (CUR). The best nanoformulation was achieved at pH 3.0, 15°C, without light incidence, and without N-2 usage. This nanoformulation showed favorable performance in terms of size, zeta potential, and encapsulation efficiency, and demonstrated potential applications in inhibiting multiple bacteria.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Chen Tan, Cristian Dima, Meigui Huang, Elham Assadpour, Jing Wang, Baoguo Sun, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: This review article discusses the recent progress in utilizing calcium carbonate particles in various advanced delivery systems. The challenges in rapid dissolution, low retention ability, and lack of sustained release are addressed through modification and integration with other encapsulation systems. The applications and challenges of these advanced systems for the protection and controlled delivery of bioactive compounds in the biological, pharmaceutical, and functional food fields are emphasized.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Food Science & Technology
Chen Tan, Xueqing Yao, Seid Mahdi Jafari, Baoguo Sun, Jing Wang
Summary: This review provides an overview of recent developments in nanocarriers based on hyaluronic acid (HA) and its derivatives. Various types of nanocarriers, including nanocomplexes, nanoparticles, nanomicelles, nanogels, and nanoemulsions, are discussed. These nanocarriers have the potential to improve the solubility, stability, and bioavailability of food-related bioactive compounds. However, their commercial utilization in the food industry is limited due to the lack of clinical evidence on potential nanotoxicity.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Oncology
Ajay Kumar, Anas Ahmad, Md Meraj Ansari, Vemana Gowd, Summya Rashid, Anis Ahmad Chaudhary, Hassan Ahmed Rudayni, Sulaiman A. Alsalamah, Rehan Khan
Summary: DNA nanostructures have shown remarkable potential in drug delivery and cancer therapy. Their high spatial addressability and self-assembly properties make them ideal for controlled drug release and targeted delivery, reducing cellular toxicity.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Food Science & Technology
Sadia Aslam, Aqsa Akhtar, Nilesh Nirmal, Nauman Khalid, Sajid Maqsood
Summary: Bioactive compounds are sensitive to degradation, limiting their applications in food and pharmaceutical products. Encapsulation in starch-based carrier systems can protect their bioactivity and ensure the sensory properties of products.
FOOD ENGINEERING REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Szota, Pawel Wolski, Cristina Carucci, Flaminia Cesare Marincola, Jacek Gurgul, Tomasz Panczyk, Andrea Salis, Barbara Jachimska
Summary: This study investigates the effect of the protonation degree of G4PAMAM dendrimer and the anticancer drug 5-fluorouracil (5FU) on the efficiency of complex formation. The most favorable conditions for constructing the G4PAMAM-5FU complex are a low degree of protonation of the dendrimer molecule with the drug simultaneously present in a deprotonated form. The formation of the stable complex is confirmed by fluorine components in the XPS spectra.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Mohammad Mahdi Rostamabadi, Seid Reza Falsafi, Katsuyoshi Nishinari, Hadis Rostamabadi
Summary: Efficient delivery systems, such as seed gum-based vehicles (SGVs), play a pivotal role in promoting the biological and functional properties of bioactive molecules. SGVs offer controlled delivery, improved bioavailability, and stability for bioactives. This article provides a comprehensive overview of seed gum-based nano- and microdevices as delivery systems for bioactive molecules, highlighting their structural properties, health benefits, and strategies for modification.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Ramesh Singh, Pankaj Yadav, Hema Naveena, Dhiraj Bhatia
Summary: Self-assembled DNA nanocages have great potential in bioimaging and payload delivery. However, the cellular uptake of tetrahedral nanocages is hindered by electrostatic repulsion. In this study, we enhance the cellular uptake of DNA nanocages through the functionalization of a model cage with a cationic lipid. The results demonstrate the enhancement in cellular uptake and suggest multiple applications in gene transfection, drug delivery, and targeted bioimaging.
Review
Biochemistry & Molecular Biology
Francesca Cuomo, Silvio Iacovino, Pasquale Sacco, Antonella De Leonardis, Andrea Ceglie, Francesco Lopez
Summary: This review presents recent advances in the delivery of bioactive phenolic compounds mediated by colloid systems. The focus is on the progress made in this field in recent years. The structural and dynamic aspects of different colloid delivery systems, as well as the interactions with two bioactive constituents, are discussed. Two case studies are presented, one representing hydrophobic phenolic compounds and the other representing hydrophilic compounds.
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Review
Biotechnology & Applied Microbiology
Humzah Jamshaid, Fakhar Ud Din, Gul Majid Khan
Summary: Nano-technology plays a significant role in the treatment and prevention of Leishmaniasis, overcoming various obstacles in traditional therapies through the design of nano-drug delivery systems and nano-vaccines. This innovative approach has improved the efficacy and safety of drugs, offering a promising solution for controlling the disease and its complications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Marcela Sarmento Valencia, Mauricio Franco da Silva Junior, Francisco Humberto Xavier-Junior, Bruno de Oliveira Veras, Priscilla Barbosa Sales de Albuquerque, Elizabeth Fernanda de Oliveira Borba, Teresinha Goncalves da Silva, Viviane Lansky Xavier, Marthyna Pessoa de Souza, Maria das Gracas Carneiro-da-Cunha
Summary: The encapsulation of curcumin into lecithin/chitosan nanoparticles was successfully achieved using electrostatic self-assembly technique. The nanoparticles showed high stability, excellent antimicrobial activity, preserved the antioxidant properties of curcumin, and exhibited moderate cytotoxicity against colorectal and lung cancer strains. These findings suggest the potential application of these nanoparticles in the nutraceutical field.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Omar S. Pillaca-Pullo, Andre Moreni Lopes, Liz M. Rodriguez-Portilla, Waldir Estela-Escalante
Summary: Coffee wastewater can be reused to produce single-cell protein, which has high potential as animal feed.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Maria Vitoria Silva Nicolini, Wedja Timoteo Vieira, Meuris Gurgel Carlos da Silva, Laura de Oliveira Nascimento, Melissa Gurgel Adeodato Vieira
Summary: A carrier based on κ-carrageenan and sericin biomacromolecules was developed to improve the treatment efficacy and patient adherence of mefenamic acid, an acid analgesic drug. The produced particles showed high encapsulation rates and drug loading, with a reproducible spherical shape and size. In vitro release experiments demonstrated good gastroresistance and sustained release properties. Cell viability assays confirmed the biocompatibility of the carrier. These findings suggest the potential application of the proposed polymer matrix for intestinal delivery of mefenamic acid.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Janaina Artem Ataide, Julia Cedran Coco, Erica Mendes dos Santos, Viviane Beraldo-Araujo, Jessica Ribeiro Alves Silva, Karine Cappuccio de Castro, Andre Moreni Lopes, Nina Filipczak, Satya Siva Kishan Yalamarty, Vladimir P. P. Torchilin, Priscila Gava Mazzola
Summary: The main goal of medicine is to achieve the best possible outcome for therapy. Nanocarriers and co-delivery strategies have been invented to meet this need, benefiting not only cancer treatment but also many other clinical issues, especially skin diseases. This review aims to summarize the research state of nanocarriers and co-delivery strategies for topical agents' applications targeting skin diseases. The challenge for future medicine lies in delivering drugs with spatial and temporal control, and the co-encapsulation of drugs and appropriate administration forms are important and unmet needs.
Article
Pharmacology & Pharmacy
Marjorie Roque, Danilo Geraldes, Caroline da Silva, Monica Oliveira, Laura Nascimento
Summary: Liposomes can enhance drug stability and minimize side effects, but they often suffer from physical and chemical instabilities. Freeze-drying can immobilize liposomes and provide extended shelf life. The choice of excipients and process parameters is crucial for protecting the carrier layers.
Article
Nanoscience & Nanotechnology
Felipe da Silva Feltrin, Natalia Aimee D'Angelo, Joao Paulo de Oliveira Guarnieri, Andre Moreni Lopes, Marcelo Lancellotti, Liliane Maria Ferrareso Lona
Summary: This study evaluated the impact of pH, temperature, light exposure, and inert atmosphere on the encapsulation of curcumin (CUR). The best nanoformulation was achieved at pH 3.0, 15°C, without light incidence, and without N-2 usage. This nanoformulation showed favorable performance in terms of size, zeta potential, and encapsulation efficiency, and demonstrated potential applications in inhibiting multiple bacteria.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Oncology
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan, Farzana Parveen, Janaina Artem Ataide, Bharat Ashok Rajmalani, Vladimir P. Torchilin
Summary: Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to traditional cancer treatments. The unique biology of GBM cells and the blood-brain barrier contribute to this resistance. However, there are several treatment options available, including surgery, chemoradiotherapy, adjuvant chemotherapy, immunotherapy, targeted therapies, and tumor-treating fields. Ongoing clinical trials aim to improve outcomes for GBM patients.
Article
Pharmacology & Pharmacy
Renata Carvalho Feitosa, Juliana Souza Ribeiro Costa, Marcelo van Vliet Lima, Elina Sawa Akioka Ishikawa, Karina Cogo Muller, Fernando Bonin Okasaki, Edvaldo Sabadini, Claudia Garnero, Marcela Raquel Longhi, Vladimir Lavayen, Arnobio Antonio da Silva-Junior, Laura Oliveira-Nascimento
Summary: In this study, the inclusion of Doxycycline (DX) in sulfobutylether-beta-CD (SBE-beta-CD) was investigated for the first time and used to reticulate chitosan. The resulting complex showed improved physicochemical characteristics and antibacterial activity, making it a potential drug delivery system for local infections.
Article
Pharmacology & Pharmacy
Louise Lacalendola Tundisi, Janaina Artem Ataide, Jessica Heline Lopes da Fonseca, Luiza Aparecida Luna Silverio, Marcelo Lancellotti, Ana Claudia Paiva-Santos, Marcos Akira d'Avila, Daniel S. Kohane, Priscila Gava Mazzola
Summary: A poloxamer 407-casein hydrogel was used to carry polycaprolactone nanoparticles loaded with terbinafine. The nanoparticles were prepared by nanoprecipitation technique and characterized. They had a mean diameter of 196.7 +/- 0.7 nm, PDI of 0.07, negative zeta potential of -0.713 mV, high encapsulation efficiency (>98%), and no cytotoxic effects in primary human keratinocytes. The rheological properties of the nanohybrid hydrogels were influenced by the addition order of TBH-PCL nanoparticles and exhibited long-term release of the nanoparticles.
Article
Food Science & Technology
Cintia G. Mendes, Joana T. Martins, Fernanda L. Ludtke, Ana Geraldo, Alfredo Pereira, Antonio A. Vicente, Jorge M. Vieira
Summary: This study aimed to assess the effect of a combined chitosan, green tea extract, and essential oil coating on the safety and quality of vacuum-packaged beef during storage. The results showed that the coating could delay lipid oxidation, reduce microbial growth, and maintain the original texture of beef cuts during storage.
Review
Biochemistry & Molecular Biology
Laura Ferreira, Patricia C. Pires, Mariana Fonseca, Gustavo Costa, Prabhanjan Shridhar Giram, Priscila Gava Mazzola, Victoria Bell, Filipa Mascarenhas-Melo, Francisco Veiga, Ana Claudia Paiva-Santos
Summary: The use of materials and products to enhance appearance and well-being can be traced back to ancient civilizations. The cosmetic industry has been evolving with a focus on innovative technological approaches. Nanotechnology has emerged as a revolutionary field with multifunctional characteristics, offering novel cosmetic products. However, the safety concerns associated with the use of nanomaterials in cosmetics need to be addressed by considering the type of nanomaterials used, their stability, potential skin absorption, route of exposure, and formulation in cosmetic products. Compliance with European regulations is crucial to ensure the safety of cosmetic products containing nanomaterials. This review explores the specificities of nanomaterials, their impact on human health, challenges related to environmental sustainability, and strategies for harmonizing policies for the standardized application of nanomaterials in cosmetics.
Review
Biochemistry & Molecular Biology
Filipa Mascarenhas-Melo, Andre R. T. S. Araujo, Marcio Rodrigues, Ankita Mathur, Maria Beatriz S. Goncalves, Kalpita Tanwar, Fariba Heidarizadeh, Fereshteh Nejaddehbashi, Abbas Rahdar, Priscila Gava Mazzola, Francisco Veiga, Ana Claudia Paiva-Santos
Summary: Resveratrol is a polyphenolic phytoalexin that is mainly found in red grapes, red wine, berries, and peanuts. When applied topically, resveratrol has good penetration and stability properties, making it suitable for dermatological and cosmetic formulations. It exhibits various beneficial effects on the skin, including anti-aging, photoprotective, estrogen-like, skin-whitening, anti-acne, wound healing, anti-scarring, antimicrobial, and anti-skin cancer properties. However, its stability is compromised when exposed to UV radiation, leading to the development of technological strategies, such as nanotechnology, to enhance its stability and efficacy.
Article
Biotechnology & Applied Microbiology
Sergio Sousa, Ana P. Carvalho, Carlos A. Pinto, Renata A. Amaral, Jorge A. Saraiva, Ricardo N. Pereira, Antonio A. Vicente, Ana C. Freitas, Ana M. Gomes
Summary: To make Nannochloropsis oculata a financially viable source for commercial applications, extraction efficiency needs to be improved. This study tested emerging technologies such as high hydrostatic pressure (HHP) and moderate electric fields (MEF), along with solvents with different polarity indexes, to increase accessibility and extraction yields of eicosapentaenoic acid (EPA). The combined use of HHP and MEF resulted in a 62% increase in EPA extraction yields from wet N. oculata biomass. These findings are highly relevant for the food and pharmaceutical industries, providing alternatives to traditional extraction methods with increased yields and reduced environmental impact.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Omar Santiago Pillaca-Pullo, Andre Moreni Lopes, Waldir D. Estela-Escalante
Summary: Coffee wastewater is a valuable resource for producing single-cell protein. Optimization using the design of experiments technique can significantly increase the yield of single-cell protein.
BIOTECHNOLOGY PROGRESS
(2023)
Article
Chemistry, Multidisciplinary
Daniel A. Madalena, Joao F. Araujo, oscar L. Ramos, Antonio A. Vicente, Ana C. Pinheiro
Summary: This study aims to assess the dynamic in vitro gastric digestion of lactoferrin/curcumin nanoparticles in the realistic gastric model (RGM). The nanosystems were characterized using various techniques, and it was observed that lactoferrin/curcumin nanoparticles were destabilized during the dynamic digestion process.
Review
Biochemistry & Molecular Biology
Erica Mendes dos Santos, Janaina Artem Ataide, Julia Cedran Coco, Ana Laura Masquetti Fava, Luiza Aparecida Luna Silverio, Ana Claudia Sueiro, Jessica Ribeiro Alves Silva, Andre Moreni Lopes, Ana Claudia Paiva-Santos, Priscila Gava Mazzola
Summary: Many plants have been used by people for generations to treat diseases, but the lack of scientific evidence supporting these uses raises safety concerns. The fruit of the Spondias genus is one such plant that generates discarded residues during processing, which also possess pharmacological properties. This review focuses on surveying the pharmacological activities of the Spondias genus, as well as the parts of the plant used, highlighting the potential reuse of its discarded by-products. The various activities exhibited by this genus, such as antioxidant, anti-inflammatory, antidiabetic, antifungal, and antiviral effects, suggest its potential for treating multiple diseases, although there are currently limited products on the market utilizing this genus as an active ingredient.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)