Article
Andrology
Sofia Amjad, Shamim Mushtaq, Rehana Rehman, Adnan Munir, Nida Zahid, Pirzada Qasim Raza Siddique
Summary: The study found that the PRM1/PRM2 mRNA ratio may serve as a more reliable and accurate marker for assessing sperm quality in patients with nonobstructive azoospermia (NOA).
Article
Biochemistry & Molecular Biology
Aina Garcia-Raventos, Antonio Munoz-Merida, Oriol Lapiedra, Mar Unzeta, Mariona Ferrandiz-Rovira, Daniel Sol
Summary: This study developed a novel method for molecular sexing of birds based on the detection of unique Z- and W-linked SNP markers. The method accurately assigned the sex of individuals in a species with reduced sexual dimorphism and different maturity stages, with high reliability and accuracy.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Andrology
Hamid Arasteh, Mohammad Ali Sadighi Gilani, Mahdi Ramezani-binabaj, Mehdi Babaei
Summary: This study aimed to investigate the sperm retrieval rate (SRR) by the mTESE method in patients who have undergone orchidopexy due to bilateral cryptorchidism. The study found that the SRR was 46% and identified significant relationships between testicular location, histological patterns, FSH, and LH levels with the sperm retrieval results.
Article
Biochemistry & Molecular Biology
Anumegha Gupta, Surendra Kumar Trigun
Summary: This study describes the effects of Cilostamide on oocytes at different meiotic stages, showing that Cilostamide treatment promotes meiotic arrest by increasing cAMP and cGMP levels and modulating related regulatory factors.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biology
Lingli Huang, Wenqing Li, Xingxing Dai, Shuai Zhao, Bo Xu, Fengsong Wang, Ren-Tao Jin, Lihua Luo, Limin Wu, Xue Jiang, Yu Cheng, Jiaqi Zou, Caoling Xu, Xianhong Tong, Heng-Yu Fan, Han Zhao, Jianqiang Bao
Summary: This study identified and characterized novel biallelic variants in MAD2L1BP responsible for oocyte maturation arrest at MI, providing new therapeutic avenues for female primary infertility.
Article
Obstetrics & Gynecology
Jiao Luo, Yan Yang, Xunmin Ji, Weiyi He, Jing Fan, Yadong Huang, Yulong Wang
Summary: The study demonstrates that nasal delivery of NGF can improve spermatogenesis in azoospermic mice by activating the HPG axis and increasing androgenic hormones.
REPRODUCTIVE SCIENCES
(2021)
Article
Andrology
Cheng-Han Tsai, I-Shen Huang, Wei-Jen Chen, Li-Hua Li, Eric Yi-Hsiu Huang, William J. Huang
Summary: This study investigated the predictive factors for successful repeat microdissection testicular sperm extraction attempts in patients with Klinefelter syndrome. The results showed that azoospermic men with nonmosaic Klinefelter syndrome and higher testosterone levels had a higher chance of successful sperm retrieval during the first microdissection testicular sperm extraction procedure. A baseline testosterone concentration of 1.5 ng/mL was identified as the threshold for predicting successful second sperm retrieval attempts in Klinefelter syndrome patients.
Article
Ecology
Deborah Charlesworth
Summary: Despite a long history of investigations of sex chromosome pairs, there is a need for more quantitative approaches to studying sex-linked regions in order to better understand their evolutionary processes and relationships between different properties.
Article
Pathology
Luke C. Olson, Joel A. Lefferts, Robert E. LeBlanc, Shaofeng Yan, Shabnam Momtahen, Aravindhan Sriharan, Konstantinos Linos
Summary: This study investigated melanocytic nevi in patients aged 40 to 74 years, identifying reproducible histomorphologic features and copy number gain of chromosome 15q. Despite cytologic variations, the histologic features showed limited variability and a characteristic pattern, without staining with BRAF V600E or NRAS Q61R immunohistochemistry. Further studies are needed to better understand the clinical and biological behavior of these lesions.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Genetics & Heredity
Hsing-Fang Lu, Ting-Yuan Liu, Yu-Pao Chou, Shih-Sheng Chang, Yow-Wen Hsieh, Jan-Gowth Chang, Fuu-Jen Tsai
Summary: Pharmacogenetic testing has not been widely used in clinical practice, and the distribution of clinically relevant pharmacogenes in large population cohorts, particularly in East Asians, has not been fully characterized. In this study, the authors comprehensively analyzed 14 actionable pharmacogene diplotypes and phenotypes in a large sample of Taiwanese Han individuals. Their findings showed comparable pharmacogenetic phenotype frequencies between their cohort and the East Asian population. Nearly all individuals (99.9%) had at least one actionable pharmacogenetic phenotype, and a significant proportion of them (29%) had been prescribed drugs that may cause atypical responses. These findings have implications for the clinical application of pharmacogenetic testing and individualized treatment optimization.
FRONTIERS IN GENETICS
(2022)
Review
Genetics & Heredity
Chariyawan Charalsawadi, Somchit Jaruratanasirikul, Areerat Hnoonual, Aussanai Chantarapong, Pornsiri Sangmanee, Sasipong Trongnit, Natini Jinawath, Pornprot Limprasert
Summary: Chimerism is a rare genetic phenomenon in humans, and only a few cases have been reported with both trisomy 21 and a normal karyotype. In this case report, a patient with ambiguous genitalia and no features of Down syndrome or other malformations was found to have a chimera with a chi 47,XY,+21/46,XX karyotype. Analyses revealed that the extra chromosome 21 was paternally derived, and meiosis I nondisjunction likely occurred during spermatogenesis. The mechanism of chimerism in this case was likely the fertilization of two spermatozoa, one with an ovum and the other with the second polar body.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Saffet Ozturk
Summary: This review comprehensively evaluates the molecular determinants of developmental and permanent arrests occurring in mammalian oocytes, and discusses potential approaches for inducing permanent arrests to obtain competent oocytes.
Article
Plant Sciences
Pervez H. Zaidi, Mohammed Shahid, Kaliyamoorthy Seetharam, Madhumal Thayil Vinayan
Summary: This study identified marker-trait associations related to salt tolerance in maize through phenotyping and genotyping, and also discovered stress-related gene models.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Hui Ma, Tao Li, Xuefeng Xie, Long Jiang, Jingwei Ye, Chenjia Gong, Hanwei Jiang, Suixing Fan, Huan Zhang, Baolu Shi, Beibei Zhang, Xiaohua Jiang, Yang Li, Jianteng Zhou, Jianze Xu, Xingxia Zhang, Xiaoning Hou, Hao Yin, Yuanwei Zhang, Qinghua Shi
Summary: This study found that RAD51AP2 plays a specific role in the formation of crossovers on XY chromosomes in the pseudoautosomal region, and its mutation leads to compromised DSB repair in PARs.
Article
Biochemical Research Methods
Sandeep Kambhampati, Sean Murphy, Hideki Uosaki, Chulan Kwon
Summary: Universal regulators during organ maturation were identified, offering the possibility for the maturation of stem cell-derived cells in vitro.
JOURNAL OF COMPUTATIONAL BIOLOGY
(2022)
Article
Immunology
Amanpreet Kaur Kalsi, Ashutosh Halder, Manish Jain, Pradeep K. Chaturvedi, Mary Mathew, Jai Bhagwan Sharma
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Shivali Jasrotia, Ritu Gupta, Atul Sharma, Ashutosh Halder, Lalit Kumar
Article
Cell Biology
Manisha Singh, Manish Jain, Samrat Bose, Ashutosh Halder, Tapas Chandra Nag, Amit Kumar Dinda, Sujata Mohanty
Summary: This study investigated the neurogenic effect of 22(R)-hydroxycholesterol on human mesenchymal stem cells derived from bone marrow, adipose tissue, and dental pulp, as well as explored their regenerative potential. Results showed that dental pulp-derived MSCs had the greatest regenerative effect post-transplantation, indicating a potential for future therapeutic use in treating Parkinson's disease.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Divya Aggarwal, Neelam Wadhwa, Tanvi Arora, Shalini Rajaram, Preeti Diwaker, Ashutosh Halder, Manish Jain, Kiran Mishra
Summary: The study explored the correlation between hTERC gene expression and chromosome 7 ploidy with worsening cytological and histological outcomes in cervical squamous carcinogenesis. It found significant positive associations for both genetic aberrations, indicating their potential relevance in settings of discrepant cytology-histology correlation. High-grade lesions had significantly higher results compared to under- or overdiagnosed cases on cytology.
Article
Reproductive Biology
Ashutosh Halder, Isha Chaudhary, Manish Jain, Shivam Pandey
Summary: In a homogeneous population of mice, skewed sex ratios were observed in preimplantation and post-implantation embryos, with a reversal skewing at birth. A high-fat diet promoted male sex ratio at birth, suggesting selective elimination of female embryos and fetuses throughout pregnancy in mice, especially with a high-fat diet.
REPRODUCTIVE BIOLOGY
(2021)
Article
Genetics & Heredity
Aiyush Sharma, Manish Jain, Ashutosh Halder, Seema Kaushal
Summary: Sertoli cell only syndrome (SCOS) is characterized by complete absence of germ cells in seminiferous tubules of testis. Genetic factors, including sex chromosomal aneuploidy and Yq Microdeletion, play a major role in the pathogenesis of SCOS. The study evaluated genomic imbalances in idiopathic SCOS patients and identified various genetic abnormalities related to SCOS pathogenesis, including sex chromosomal abnormalities and Yq microdeletions. Further research is needed to explore the mechanisms of these genomic imbalances in the pathogenesis of SCOS.
Article
Biochemistry & Molecular Biology
Neha Kaushik, Soumya Rastogi, Sonia Verma, Deepak Pandey, Ashutosh Halder, Arnab Mukhopadhyay, Neeraj Kumar
Summary: In C. elegans, reduced insulin signaling (rIIS) leads to differential regulation of target genes by the transcription factors DAF-16/FOXO, SKN-1/Nrf-1, and HSF1/HSF-1. DAF-16 acts primarily as an activator under rIIS, while SKN-1 and HSF-1 function as both activators and repressors. Regardless of activation or repression, DAF-16 is the principal determining factor for genes commonly regulated by TFs under rIIS conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Hemant Kumar, Ashutosh Halder, Mona Sharma, Manish Jain, Amanpreet Kaur Kalsi
Summary: The study aimed to evaluate different androgens in PCOS women from north India to determine the best available biomarker. The results showed that Dihydrotestosterone (DHT) can be considered as a diagnostic biomarker of hyperandrogenemia in PCOS women from north India.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2022)
Meeting Abstract
Oncology
Prasanth Srinivasan, Jagdish Prasad Meena, Aditya Gupta, Ashutosh Halder, Arti Kapil, Rm Pandey, Rachna Seth
PEDIATRIC BLOOD & CANCER
(2022)
Article
Medicine, General & Internal
Amanpreet Kaur Kalsi, Ashutosh Halder, Manish Jain, Amita Srivastava
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2020)
Article
Medicine, General & Internal
Isha Rishi, Ashutosh Halder, J. B. Sharma, Manish Jain, Mona Sharma
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2020)
Article
Pathology
Pragya Jain, Neelam Wadhwa, Mohit K. Joshi, Manish Jain, Ashutosh Halder, Kiran Mishra
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2020)
Article
Endocrinology & Metabolism
Amanpreet Kaur Kalsi, Ashutosh Halder, Manish Jain, P. K. Chaturvedi, J. B. Sharma
Article
Medicine, General & Internal
Ashutosh Halder, Manish Jain, Amanpreet Kaur Kalsi
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2018)
Article
Andrology
P. Kumar, M. Jain, A. K. Kalsi, A. Halder
