Discovery and function of transfer RNA-derived fragments and their role in disease

MINTbase: a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments

(2016) Venetia Pliatsika et al.   BIOINFORMATICS

Molecular Basis and Consequences of the Cytochromec-tRNA Interaction

(2016) Cuiping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

tRNA-Derived RNA Fragments Associate with Human Multisynthetase Complex (MSC) and Modulate Ribosomal Protein Translation

(2016) Simon P. Keam et al.   JOURNAL OF PROTEOME RESEARCH

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers

(2016) Ling-Ling Zheng et al.   NUCLEIC ACIDS RESEARCH

Genome-wide identification and characterization of tRNA-derived RNA fragments in land plants

(2016) Cristiane S. Alves et al.   PLANT MOLECULAR BIOLOGY

A comprehensive repertoire of tRNA-derived fragments in prostate cancer

(2016) Michael Olvedy et al.   Oncotarget

Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

(2016) Jennifer E. Cropley et al.   Molecular Metabolism

Identification of aberrant tRNA-halves expression patterns in clear cell renal cell carcinoma

(2016) Malin Nientiedt et al.   Scientific Reports

Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets

(2015) Spyros Karaiskos et al.   Biology Direct

Precise mapping and dynamics of tRNA-derived fragments (tRFs) in the development of Triops cancriformis (tadpole shrimp)

(2015) Yuka Hirose et al.   BMC GENETICS

Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes

(2015) Yan Guo et al.   BMC GENOMICS

Conserved and highly expressed tRNA derived fragments in zebrafish

(2015) Ana Raquel Soares et al.   BMC MOLECULAR BIOLOGY

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Viral noncoding RNAs: more surprises

(2015) Kazimierz T. Tycowski et al.   GENES & DEVELOPMENT

Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains

(2015) Ha Yeon Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes "microRNA-like" tRNA Fragments

(2015) N. Guzman et al.   MOLECULAR CANCER RESEARCH

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

(2015) Junfang Deng et al.   MOLECULAR THERAPY

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

The biological functions of miRNAs: lessons from in vivo studies

(2015) Joana A. Vidigal et al.   TRENDS IN CELL BIOLOGY

Circulating small non coding RNA signature in head and neck squamous cell carcinoma

(2015) Berta Victoria Martinez et al.   Oncotarget

Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies

(2015) Aristeidis G. Telonis et al.   Oncotarget

Characterization of circulating transfer RNA-derived RNA fragments in cattle

(2015) Eduardo Casas et al.   Frontiers in Genetics

Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

(2014) Pankaj Kumar et al.   BMC BIOLOGY

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

Small Noncoding RNAs in Cells Transformed by Human T-Cell Leukemia Virus Type 1: a Role for a tRNA Fragment as a Primer for Reverse Transcriptase

(2014) K. Ruggero et al.   JOURNAL OF VIROLOGY

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

tRFdb: a database for transfer RNA fragments

(2014) Pankaj Kumar et al.   NUCLEIC ACIDS RESEARCH

Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway

(2014) M Miyake et al.   ONCOGENE

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Human Metapneumovirus Infection Induces Significant Changes in Small Noncoding RNA Expression in Airway Epithelial Cells

(2014) Junfang Deng et al.   Molecular Therapy-Nucleic Acids

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Links between the Oncoprotein YB-1 and Small Non-Coding RNAs in Breast Cancer

(2013) Cherie Blenkiron et al.   PLoS One

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells

(2013) M. Pavon-Eternod et al.   RNA

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

tRNA-Derived Fragments Target the Ribosome and Function as Regulatory Non-Coding RNA inHaloferax volcanii

(2012) Jennifer Gebetsberger et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer

(2011) E S Martens-Uzunova et al.   ONCOGENE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

tRNA Binds to Cytochrome c and Inhibits Caspase Activation

(2010) Yide Mei et al.   MOLECULAR CELL

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

Functional expansion of human tRNA synthetases achieved by structural inventions

(2009) Min Guo et al.   FEBS LETTERS

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

tRNA over-expression in breast cancer and functional consequences

(2009) Mariana Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid

(2009) Man Lung Yeung et al.   NUCLEIC ACIDS RESEARCH

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

Hidden layers of human small RNAs

(2008) Hideya Kawaji et al.   BMC GENOMICS

Sequence variants of elaC homolog 2 (Escherichia coli) ( ELAC2 ) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study

(2008) Yen-Ching Chen et al.   CARCINOGENESIS

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

tRNA and protein methylase complexes mediate zymocin toxicity in yeast

(2008) Patrick Studte et al.   MOLECULAR MICROBIOLOGY

The primary target of the killer toxin fromPichia acaciaeis tRNAGln

(2008) Roland Klassen et al.   MOLECULAR MICROBIOLOGY

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA