RNA versatility, flexibility, and thermostability for practice in RNA nanotechnology and biomedical applications

RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21

(2017) Tae Jin Lee et al.   MOLECULAR THERAPY

RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery

(2017) Fengmei Pi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Versatile RNA tetra-U helix linking motif as a toolkit for nucleic acid nanotechnology

(2017) My N. Bui et al.   Nanomedicine-Nanotechnology Biology and Medicine

Thermodynamic stabilities of three-way junction nanomotifs in prohead RNA

(2017) Alyssa C. Hill et al.   RNA

Directional mechanical stability of Bacteriophage φ29 motor’s 3WJ-pRNA: Extraordinary robustness along portal axis

(2017) Zhonghe Xu et al.   Science Advances

Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles

(2016) Yijuan Zhang et al.   ACS Nano

Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting

(2016) Hui Li et al.   ADVANCED MATERIALS

Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs

(2016) Emil F. Khisamutdinov et al.   ADVANCED MATERIALS

Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles

(2016) Mark A. Boerneke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ring Catalog: A resource for designing self-assembling RNA nanostructures

(2016) Lorena Parlea et al.   METHODS

Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology

(2016) Daniel W Binzel et al.   MOLECULAR THERAPY

Controllable self-assembly of RNA dendrimers

(2016) Ashwani Sharma et al.   Nanomedicine-Nanotechnology Biology and Medicine

A quasi-cyclic RNA nano-scale molecular object constructed using kink turns

(2016) Lin Huang et al.   Nanoscale

Three-way junction conformation dictates self-association of phage packaging RNAs

(2016) Yumeng Hao et al.   RNA Biology

Mechanism of three-component collision to produce ultrastable pRNA three-way junction of Phi29 DNA-packaging motor by kinetic assessment

(2016) Daniel W. Binzel et al.   RNA

Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

(2015) Dan Shu et al.   ACS Nano

RNA quaternary structure and global symmetry

(2015) Christopher P. Jones et al.   TRENDS IN BIOCHEMICAL SCIENCES

De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism

(2015) Jinwen Yu et al.   Nature Communications

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

(2015) Tae Jin Lee et al.   Oncotarget

Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA

(2015) Daxiang Cui et al.   Scientific Reports

Physicochemically Tunable Polyfunctionalized RNA Square Architecture with Fluorogenic and Ribozymatic Properties

(2014) Daniel L. Jasinski et al.   ACS Nano

RNA as a Boiling-Resistant Anionic Polymer Material To Build Robust Structures with Defined Shape and Stoichiometry

(2014) Emil F. Khisamutdinov et al.   ACS Nano

Entropy-Driven One-Step Formation of Phi29 pRNA 3WJ from Three RNA Fragments

(2014) Daniel W. Binzel et al.   BIOCHEMISTRY

Nucleic Acid Aptamer-Mediated Drug Delivery for Targeted Cancer Therapy

(2014) Huijie Zhu et al.   ChemMedChem

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

(2014) Emil F. Khisamutdinov et al.   NUCLEIC ACIDS RESEARCH

Construction of RNA nanocages by re-engineering the packaging RNA of Phi29 bacteriophage

(2014) Chenhui Hao et al.   Nature Communications

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

Rewriting a genome

(2013) Emmanuelle Charpentier et al.   NATURE

Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells

(2013) Yi Shu et al.   Nature Protocols

Programmable folding of fusion RNA in vivo and in vitro driven by pRNA 3WJ motif of phi29 DNA packaging motor

(2013) Dan Shu et al.   NUCLEIC ACIDS RESEARCH

Ocular Delivery of pRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection

(2013) Liang Feng et al.   PHARMACEUTICAL RESEARCH

Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs

(2013) Y. Shu et al.   RNA

Crystal structure of 3WJ core revealing divalent ion-promoted thermostability and assembly of the Phi29 hexameric motor pRNA

(2013) H. Zhang et al.   RNA

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Co-transcriptional Assembly of Chemically Modified RNA Nanoparticles Functionalized with siRNAs

(2012) Kirill A. Afonin et al.   NANO LETTERS

Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers

(2012) Farzin Haque et al.   Nano Today

Current Progress of RNA Aptamer-Based Therapeutics

(2012) Jiehua Zhou et al.   Frontiers in Genetics

Multistrand RNA Secondary Structure Prediction and Nanostructure Design Including Pseudoknots

(2011) Eckart Bindewald et al.   ACS Nano

Large scale expression and purification of recombinant RNA in Escherichia coli

(2011) Luc Ponchon et al.   METHODS

Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells

(2011) Yi Shu et al.   METHODS

Self-Assembling RNA Nanorings Based on RNAI/II Inverse Kissing Complexes

(2011) Wade W. Grabow et al.   NANO LETTERS

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Synthetic RNA–protein complex shaped like an equilateral triangle

(2011) Hirohisa Ohno et al.   Nature Nanotechnology

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

Attenuation of loop-receptor interactions with pseudoknot formation

(2011) Kirill A. Afonin et al.   NUCLEIC ACIDS RESEARCH

Self-assembling RNA square

(2011) S. M. Dibrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fabrication of Stable and RNase-Resistant RNA Nanoparticles Active in Gearing the Nanomotors for Viral DNA Packaging

(2010) Jing Liu et al.   ACS Nano

Therapeutic applications of ribozymes and riboswitches

(2010) Jérôme Mulhbacher et al.   CURRENT OPINION IN PHARMACOLOGY

A polyhedron made of tRNAs

(2010) Isil Severcan et al.   Nature Chemistry

In vitro assembly of cubic RNA-based scaffolds designed in silico

(2010) Kirill A. Afonin et al.   Nature Nanotechnology

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

A structural database for k-turn motifs in RNA

(2010) K. T. Schroeder et al.   RNA

The Dynamic Landscapes of RNA Architecture

(2009) José Almeida Cruz et al.   CELL

Analysis of Four-Way Junctions in RNA Structures

(2009) Christian Laing et al.   JOURNAL OF MOLECULAR BIOLOGY

Square-Shaped RNA Particles from Different RNA Folds

(2009) Isil Severcan et al.   NANO LETTERS

TokenRNA: A New Type of Sequence-Specific, Label-Free Fluorescent Biosensor for Folded RNA Molecules

(2008) Kirill A. Afonin et al.   CHEMBIOCHEM

Computational strategies for the automated design of RNA nanoscale structures from building blocks using NanoTiler

(2008) Eckart Bindewald et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Specific RNA Self-Assembly with Minimal Paranemic Motifs

(2007) Kirill A. Afonin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY