Article
Cardiac & Cardiovascular Systems
Noah Weingarten, Amit Iyengar, David Alan Herbst, Mark Helmers, David Rekhtman, Cindy Song, Samuel T. Kim, Pavan Atluri
Summary: In obese patients with non-dialysis-dependent kidney disease, simultaneous heart-kidney transplant (HKT) may decrease long-term mortality compared to isolated heart transplant (IHT), and should be strongly considered as a preferred treatment.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Charat Thongprayoon, Shennen A. Mao, Caroline C. Jadlowiec, Michael A. Mao, Napat Leeaphorn, Wisit Kaewput, Pradeep Vaitla, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Fawad Qureshi, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: This study used an unsupervised machine learning approach to investigate morbidly obese kidney transplant recipients and found varying post-transplant outcomes among different clusters. Recipients with earlier access to transplantation and living donor kidneys demonstrated superior survival rates. The reduced graft survival in cluster 3 recipients may highlight socioeconomic disparities in post-transplant support and access to preemptive and living donor transplants. Obesity itself should be reconsidered as a strict barrier to kidney transplantation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Alexandre Veronese-Araujo, Debora D. de Lucena, Isabella Aguiar-Brito, Luis Gustavo Modelli de Andrade, Marina P. P. Cristelli, Helio Tedesco-Silva, Jose O. Medina-Pestana, Erika B. Rangel
Summary: Obesity is a component of the cardiometabolic syndrome that worsens the progression and mortality of COVID-19. In this study, the impact of overweight/obesity and kidney transplant on oxygen requirements in COVID-19 patients was investigated. The results showed that obesity was an independent risk factor for oxygen requirements in overweight/obese kidney transplant recipients, particularly in older individuals and smokers.
Editorial Material
Biochemistry & Molecular Biology
Nissrin Alachkar, Nada Alachkar
Summary: Diagnosing kidney allograft rejection is complex and subjective, but an automated Banff classification could make assessment easier and improve accuracy.
Review
Transplantation
Paul Emile Levy, Sadiya S. Khan, Lisa B. VanWagner
Summary: Cardiac events have become the leading cause of morbidity and mortality after liver and kidney transplantation. Assessment of coronary artery disease using computed tomography coronary angiography is preferred, while assessment of cardiac structure and function using transthoracic echocardiography with tissue doppler imaging and strain imaging is recommended. Risk stratification should consider both anatomic and functional consequences of coronary artery disease.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2021)
Article
Nursing
Keke Lin, Changyun Wei, Jiaqi Li, Xuejie Guo, Fengli Gao, Peiyu Zhao, Hongxia Liu
Summary: This study aimed to develop a Self-management Support Scale for Kidney Transplant Recipients (SMSSKTR) and test its psychometric properties. A 22-item scale was developed through literature review, interviews, and expert evaluation. The scale demonstrated good reliability and validity through factor analysis and confirmatory factor analysis.
Article
Health Care Sciences & Services
Conner V. Lombardi, Jacob J. Lang, Meng-Hao Li, Abu Bakkar Siddique, Naoru Koizumi, Obi Ekwenna
Summary: The objective of this retrospective study was to examine how the COVID-19 pandemic affected transplant status among different demographic groups. The results showed significant variations in waitlist status and disposition based on race, sex, age, primary insurance, and geographic regions. Minority patients, older patients, and those in counties with high COVID-19 deaths experienced longer wait times, while older, White, male, Medicare, and high CPRA patients had a higher risk of waitlist removal due to severe sickness or death.
Article
Urology & Nephrology
Ugo Pinar, Arthur Mageau, Yohann Renard, Xavier Rod, Cedric Lebacle, Benoit Barrou, Mohamad Zaidan, Jacques Irani, Thomas Bessede
Summary: High visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were associated with post-transplantation dialysis. A predictive model based on these morphometric markers could provide a better assessment of graft recovery after transplantation among obese and overweight recipients. External validation of this model is needed.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Transplantation
Lina Maria Serna-Higuita, Andrea Della Penna, Martina Guthoff, Nils Heyne, Sandra Beer-Hammer, Silvio Nadalin, Peter Martus, Alfred Koenigsrainer, Markus Quante
Summary: This study analyzed the clinical outcomes of obese transplantation recipients under different immunosuppressive protocols. The findings showed that in obese recipients treated with mTORi-Tac, the incidence of acute rejection was lower. However, in obese recipients treated with Tac-MMF, there was an increased risk of cardiovascular events and mortality due to infection.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Chukwuma A. Chukwu, Kassir Mahmood, Safa Elmakki, Julie Gorton, Phillip A. Kalra, Dimitrios Poulikakos, Rachel Middleton
Summary: This study evaluated the antibody response to SARS-COV-2 vaccines in 707 kidney transplant recipients and found a poor response after two doses of the vaccine. The use of mycophenolic acid, an immunosuppressive drug used after kidney transplantation, had a negative impact on vaccine response.
Review
Biochemistry & Molecular Biology
Anna Radajewska, Anna Krzywonos-Zawadzka, Iwona Bil-Lula
Summary: Kidney transplantation is the standard procedure for treating end-stage renal disease, and machine perfusion has been proven to be a better solution for organ preservation and monitoring.
Article
Multidisciplinary Sciences
Amy D. Westerling-Bui, Eva Maria Fast, Thomas W. Soare, Srinivasan Venkatachalan, Michael DeRan, Alyssa B. Fanelli, Sergii Kyrychenko, Hien Hoang, Grinal M. Corriea, Wei Zhang, Maolin Yu, Matthew Daniels, Goran Malojcic, Xin-Ru Pan-Zhou, Mark W. Ledeboer, Jean-Christophe Harmange, Maheswarareddy Emani, Thomas T. Tibbitts, John F. Reilly, Peter Mundel
Summary: Pharmacodynamic (PD) studies are crucial in preclinical drug discovery, but current approaches limited to animal models lack translatability to humans. To overcome this challenge, researchers developed a novel method using transplanted human kidney organoids for PD studies. By orally administering investigational drug GFB-887 to athymic rats with transplanted organoids, significant protection of kidney filter cells was observed in both the organoids and host kidneys.
Article
Urology & Nephrology
Xiaomeng Chen, Nadia M. Chu, Pragyashree Sharma Basyal, Wasurut Vihokrut, Deidra Crews, Daniel C. Brennan, Sarah R. Andrews, Tracy D. Vannorsdall, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Depressive symptoms are common in kidney failure patients even without a clinical diagnosis of depression, and they may hinder the completion of kidney transplant evaluation. The severity of depressive symptoms is associated with age, with older candidates being less likely to report such symptoms. Regardless of age, candidates who report depressive symptoms have a lower chance of being listed for kidney transplant.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Torsten R. Goesch, Nancy A. Wilson, Weifeng Zeng, Bret M. Verhoven, Weixiong Zhong, Maya M. Coumbe Gitter, William E. Fahl
Summary: PrC-210 has shown potential to suppress kidney damage and inflammation caused by allograft kidney transplantation, reducing histologic damage, improving kidney function metrics, and decreasing levels of inflammatory cytokines and activated caspase.
Article
Cardiac & Cardiovascular Systems
Kenley M. Pelzer, Kevin C. Zhang, Kevin A. Lazenby, Nikhil Narang, Matthew M. Churpek, Allen S. Anderson, William F. Parker
Summary: The U.S. heart allocation system, which ranks candidates based on 6 treatment categories, has only moderate ability to identify the most urgent heart transplant candidates and overlooks important patient characteristics. However, predictive models that incorporate physiological measurements can more effectively prioritize heart transplant candidates by urgency.
JACC-HEART FAILURE
(2023)
