Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice

(2021) Amar J. Majmundar et al.   Science Advances

TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models

(2021) Yiming Zhou et al.   Frontiers in Medicine

Synaptopodin Is Dispensable for Normal Podocyte Homeostasis but Is Protective in the Context of Acute Podocyte Injury

(2020) Liang Ning et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

(2019) Moran Dvela-Levitt et al.   CELL

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

(2019) Jian Hui Low et al.   Cell Stem Cell

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes

(2019) Tracy Tran et al.   DEVELOPMENTAL CELL

A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases

(2019) Kitty J. Jager et al.   KIDNEY INTERNATIONAL

Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model

(2019) Maolin Yu et al.   ACS Medicinal Chemistry Letters

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

(2019) Ayshwarya Subramanian et al.   Nature Communications

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

(2018) Cathelijne W. van den Berg et al.   Stem Cell Reports

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

(2018) Christopher E. Gillies et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Organoids for Drug Discovery and Personalized Medicine

(2018) Toshio Takahashi   Annual Review of Pharmacology and Toxicology

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney

(2018) Rajasree Menon et al.   DEVELOPMENT

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

(2018) Lorna J. Hale et al.   Nature Communications

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

(2017) Yiming Zhou et al.   SCIENCE

Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes

(2016) Lisa Buvall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Erratum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2016) Minoru Takasato et al.   NATURE

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

(2015) Monika S. Kowalczyk et al.   GENOME RESEARCH

Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation

(2015) S. Sharmin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Publishing and sharing multi-dimensional image data with OMERO

(2015) Jean-Marie Burel et al.   MAMMALIAN GENOME

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

The Landscape of Clinical Trials in Nephrology: A Systematic Review of ClinicalTrials.gov

(2013) Jula K. Inrig et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Biology and Pathology of Podocytes

(2011) Anna Greka et al.   Annual Review of Physiology

Focal Segmental Glomerulosclerosis

(2011) Vivette D. D'Agati et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

(2008) Christian Faul et al.   NATURE MEDICINE

Proteinuria and Immunity — An Overstated Relationship?

(2008) Peter W. Mathieson   NEW ENGLAND JOURNAL OF MEDICINE