Cellular and Molecular Aspects of the β-N-Methylamino-l-alanine (BMAA) Mode of Action within the Neurodegenerative Pathway: Facts and Controversy

Neuromelanin in parkinsonian disorders: an update

(2017) Antonio Martin-Bastida et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Transport of BMAA into Neurons and Astrocytes by System xc-

(2017) Rebecca Albano et al.   NEUROTOXICITY RESEARCH

β-N-Methylamino-L-Alanine Toxicity in PC12: Excitotoxicity vs. Misincorporation

(2017) R. van Onselen et al.   NEUROTOXICITY RESEARCH

Exposure to BMAA mirrors molecular processes linked to neurodegenerative disease

(2017) Joshua Beri et al.   PROTEOMICS

Production of BMAA and DAB by diatoms ( Phaeodactylum tricornutum , Chaetoceros sp., Chaetoceros calcitrans and, Thalassiosira pseudonana ) and bacteria isolated from a diatom culture

(2016) Damien Réveillon et al.   HARMFUL ALGAE

Protective effects of isolecanoric acid on neurodegenerative in vitro models

(2016) Nuria de Pedro et al.   NEUROPHARMACOLOGY

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

(2016) Estefanía de Munck et al.   PLoS One

Transfer of developmental neurotoxin β- N -methylamino- l -alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis

(2016) Marie Andersson et al.   TOXICOLOGY LETTERS

Systematic detection of BMAA (β-N-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in mollusks collected in shellfish production areas along the French coasts

(2016) Damien Réveillon et al.   TOXICON

β-methylamino-L-alanine (BMAA) is not found in the brains of patients with confirmed Alzheimer’s disease

(2016) Julie P. Meneely et al.   Scientific Reports

Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA)

(2016) Ann Kristin Frøyset et al.   Scientific Reports

Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease

(2016) Ioannis U. Isaias et al.   Frontiers in Aging Neuroscience

β-N-methylamino-l-alanine (BMAA) and isomers: Distribution in different food web compartments of Thau lagoon, French Mediterranean Sea

(2015) Damien Réveillon et al.   MARINE ENVIRONMENTAL RESEARCH

A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam

(2015) John C. Steele et al.   MOVEMENT DISORDERS

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

(2015) Simona Eleuteri et al.   NEUROBIOLOGY OF DISEASE

Detection of BMAA in the human central nervous system

(2015) L. Berntzon et al.   NEUROSCIENCE

Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)

(2015) Emma Muñoz-Sáez et al.   NEUROSCIENCE LETTERS

Analysis of β-N-methylamino- l -alanine (L-BMAA) neurotoxicity in rat cerebellum

(2015) Emma Muñoz-Sáez et al.   NEUROTOXICOLOGY

Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (β-N-methylamino-L-alanine) in neonatal rat brain

(2015) Oskar Karlsson et al.   Scientific Reports

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

The natural non-protein amino acid N-β-methylamino-l-alanine (BMAA) is incorporated into protein during synthesis

(2014) W. Broc Glover et al.   AMINO ACIDS

BMAA in shellfish from two Portuguese transitional water bodies suggests the marine dinoflagellate Gymnodinium catenatum as a potential BMAA source

(2014) Sandra Lage et al.   AQUATIC TOXICOLOGY

Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

(2014) Oskar Karlsson et al.   ARCHIVES OF TOXICOLOGY

Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord

(2014) Hong Z. Yin et al.   EXPERIMENTAL NEUROLOGY

Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

(2014) Khalid Iqbal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Beta-N-Methylamino-l-Alanine: LC-MS/MS Optimization, Screening of Cyanobacterial Strains and Occurrence in Shellfish from Thau, a French Mediterranean Lagoon

(2014) Damien Réveillon et al.   Marine Drugs

Oxidative Stress and Autophagic Alteration in Brainstem of SOD1-G93A Mouse Model of ALS

(2014) Ting An et al.   MOLECULAR NEUROBIOLOGY

Diatoms: A Novel Source for the Neurotoxin BMAA in Aquatic Environments

(2014) Liying Jiang et al.   PLoS One

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

(2014) M. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein association of the neurotoxin and non-protein amino acid BMAA (β-N-methylamino-l-alanine) in the liver and brain following neonatal administration in rats

(2014) Oskar Karlsson et al.   TOXICOLOGY LETTERS

Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida

(2014) Sandra Anne Banack et al.   TOXICON

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS

(2013) Estefanía de Munck et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Thymoquinone Attenuates Astrogliosis, Neurodegeneration, Mossy Fiber Sprouting, and Oxidative Stress in a Model of Temporal Lobe Epilepsy

(2013) Sharareh Dariani et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats

(2013) Oskar Karlsson et al.   JOURNAL OF PROTEOME RESEARCH

^|^beta;-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma

(2013) Emma Mu^|^ntilde;oz-Saez et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Neuromelanin of the Human Substantia Nigra: An Update

(2013) Fabio A. Zucca et al.   NEUROTOXICITY RESEARCH

The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation

(2013) Rachael Anne Dunlop et al.   PLoS One

Gliotoxicity of the cyanotoxin, β-methyl-amino-L-alanine (BMAA)

(2013) Alexander S. Chiu et al.   Scientific Reports

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Agrochemicals, α-Synuclein, and Parkinson’s Disease

(2012) Blanca A. Silva et al.   MOLECULAR NEUROBIOLOGY

Biosynthetic pathway to neuromelanin and its aging process

(2012) Kazumasa Wakamatsu et al.   Pigment Cell & Melanoma Research

Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

(2012) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

L-BMAA Induced ER Stress and Enhanced Caspase 12 Cleavage in Human Neuroblastoma SH-SY5Y Cells at Low Nonexcitotoxic Concentrations

(2012) Oliver Okle et al.   TOXICOLOGICAL SCIENCES

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

The ALS/PDC syndrome of Guam: Potential biomarkers for an enigmatic disorder

(2011) Patrick L. McGeer et al.   PROGRESS IN NEUROBIOLOGY

Nitrogen starvation of cyanobacteria results in the production of β-N-methylamino-L-alanine

(2011) S. Downing et al.   TOXICON

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

(2010) Emanuele Buratti et al.   RNA Biology

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

(2009) J. Pablo et al.   ACTA NEUROLOGICA SCANDINAVICA

Augmentation and ionic mechanism of effect of β-N-methylamino-l-alanine in presence of bicarbonate on membrane potential of Retzius nerve cells of the leech Haemopis sanguisuga

(2009) Srdjan Lopicic et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

β-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc−

(2009) XiaoQian Liu et al.   EXPERIMENTAL NEUROLOGY

Mutation withinTARDBPleads to Frontotemporal Dementia without motor neuron disease

(2009) B. Borroni et al.   HUMAN MUTATION

β-N-methylamino-l-alanine inducedin vivoretinal cell death

(2009) Serena Santucci et al.   JOURNAL OF NEUROCHEMISTRY

Selective death of cholinergic neurons induced by beta-methylamino-L-alanine

(2009) Xiao Qian Liu et al.   NEUROREPORT

Domoic acid and human exposure risks: A review

(2009) Kathi A. Lefebvre et al.   TOXICON

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Retention of the cyanobacterial neurotoxinβ-N-methylamino-l-alanine in melanin and neuromelanin-containing cells - a possible link between Parkinson-dementia complex and pigmentary retinopathy

(2008) Oskar Karlsson et al.   Pigment Cell & Melanoma Research

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

(2008) L. Zecca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA