A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease
Authors
Keywords
Proteases, Luciferase, Library screening, Zika virus, West Nile virus, Dengue virus, Flaviviruses, Luciferase assay
Journal
PLoS Pathogens
Volume 13, Issue 5, Pages e1006411
Publisher
Public Library of Science (PLoS)
Online
2017-05-26
DOI
10.1371/journal.ppat.1006411
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
- (2016) Xuyu Qian et al. CELL
- Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission
- (2016) Takako Tabata et al. Cell Host & Microbe
- Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
- (2016) Hengli Tang et al. Cell Stem Cell
- Zika virus impairs growth in human neurospheres and brain organoids
- (2016) P. P. Garcez et al. SCIENCE
- Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
- (2016) Wint Wint Phoo et al. Nature Communications
- Zika virus is a global public health emergency, declares WHO
- (2016) Anne Gulland BMJ-British Medical Journal
- Zika virus is a global public health emergency, declares WHO
- (2016) Anne Gulland BMJ-British Medical Journal
- Local Transmission of Zika Virus — Puerto Rico, November 23, 2015–January 28, 2016
- (2016) Dana L. Thomas et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses — Brazil, 2015
- (2016) Roosecelis Brasil Martines et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
- (2015) Dahai Luo et al. ANTIVIRAL RESEARCH
- Conformational change study of dengue virus NS2B-NS3 protease using 19F NMR spectroscopy
- (2015) Lei Zhu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Split-luciferase complementary assay: applications, recent developments, and future perspectives
- (2014) Taha Azad et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery
- (2014) Bruno Coutard et al. ANTIVIRAL RESEARCH
- Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease
- (2014) Laura de la Cruz et al. FEBS Journal
- An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease
- (2014) Hua Li et al. FEBS LETTERS
- The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI
- (2014) Wan-Na Chen et al. FEBS LETTERS
- An Allosteric Modulator of HIV-1 Protease Shows Equipotent Inhibition of Wild-Type and Drug-Resistant Proteases
- (2014) Peter M.-U. Ung et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus
- (2013) Muslum Yildiz et al. ACS Chemical Biology
- Ten years of dengue drug discovery: Progress and prospects
- (2013) Siew Pheng Lim et al. ANTIVIRAL RESEARCH
- NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex
- (2013) Young Mee Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase
- (2013) Hui Chen et al. PLoS One
- The flavivirus protease as a target for drug discovery
- (2013) Matthew Brecher et al. VIROLOGICA SINICA
- Structural biology of dengue virus enzymes: Towards rational design of therapeutics
- (2012) Christian G. Noble et al. ANTIVIRAL RESEARCH
- Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs
- (2012) Hui Chen et al. ANTIVIRAL RESEARCH
- Exploring the binding of peptidic West Nile virus NS2B–NS3 protease inhibitors by NMR
- (2012) CongBao Kang et al. ANTIVIRAL RESEARCH
- Encephalitis caused by flaviviruses
- (2012) L. Turtle et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- Flaviviruses and flavivirus vaccines
- (2012) Franz X. Heinz et al. VACCINE
- Binding of Low Molecular Weight Inhibitors Promotes Large Conformational Changes in the Dengue Virus NS2B-NS3 Protease: Fold Analysis by Pseudocontact Shifts
- (2011) Laura de la Cruz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation
- (2011) C. G. Noble et al. JOURNAL OF VIROLOGY
- Open Babel: An open chemical toolbox
- (2011) Noel M O'Boyle et al. Journal of Cheminformatics
- New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
- (2010) Jonathan B. Baell et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases
- (2010) Benjamin W. Jester et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure-based discovery of dengue virus protease inhibitors
- (2009) Suzanne M. Tomlinson et al. ANTIVIRAL RESEARCH
- The construction of a glucose-sensing luciferase
- (2009) Atsushi Taneoka et al. BIOSENSORS & BIOELECTRONICS
- NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease
- (2009) Xun-Cheng Su et al. FEBS Journal
- Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication
- (2009) R. Assenberg et al. JOURNAL OF VIROLOGY
- Serotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus Family
- (2009) S. Chandramouli et al. JOURNAL OF VIROLOGY
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- Activation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanism
- (2009) Dariusz Ekonomiuk et al. PROTEIN SCIENCE
- NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease
- (2009) Xun-Cheng Su et al. PLoS Neglected Tropical Diseases
- Novel Genetically Encoded Biosensors Using Firefly Luciferase
- (2008) Frank Fan et al. ACS Chemical Biology
- An Integrated-Molecule-Format Multicolor Probe for Monitoring Multiple Activities of a Bioactive Small Molecule
- (2008) Sung Bae Kim et al. ACS Chemical Biology
- An intracellular conformational sensor assay for Abl T315I
- (2008) Vicki Zhou et al. ANALYTICAL BIOCHEMISTRY
- Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target
- (2008) J LESCAR et al. ANTIVIRAL RESEARCH
- Molecular targets for flavivirus drug discovery
- (2008) Aruna Sampath et al. ANTIVIRAL RESEARCH
- Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases
- (2008) Peteris Prusis et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein
- (2008) Dahai Luo et al. EMBO JOURNAL
- Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity
- (2008) K. J. Chappell et al. JOURNAL OF GENERAL VIROLOGY
- Structure of West Nile Virus NS3 Protease: Ligand Stabilization of the Catalytic Conformation
- (2008) Gautier Robin et al. JOURNAL OF MOLECULAR BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search