The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors

Substitution of Herpes Simplex Virus 1 Entry Glycoproteins with Those of Saimiriine Herpesvirus 1 Reveals a gD-gH/gL Functional Interaction and a Region within the gD Profusion Domain That Is Critical for Fusion

(2014) Q. Fan et al.   JOURNAL OF VIROLOGY

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors

(2013) D. Atanasiu et al.   mBio

Preclinical Therapy of Disseminated HER-2+ Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus

(2013) Patrizia Nanni et al.   PLoS Pathogens

αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion

(2013) Tatiana Gianni et al.   PLoS Pathogens

Novel Mutations in gB and gH Circumvent the Requirement for Known gD Receptors in Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread

(2012) Hiroaki Uchida et al.   JOURNAL OF VIROLOGY

Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial

(2012) José Baselga et al.   LANCET

Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade Glioma

(2012) Eleonora Gambini et al.   MOLECULAR THERAPY

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

Viral and cellular contributions to herpes simplex virus entry into the cell

(2012) Gabriella Campadelli-Fiume et al.   Current Opinion in Virology

Fusing structure and function: a structural view of the herpesvirus entry machinery

(2011) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rethinking herpes simplex virus: the way to oncolytic agents

(2011) Gabriella Campadelli-Fiume et al.   REVIEWS IN MEDICAL VIROLOGY

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

(2011) Paolo Di Giovine et al.   PLoS Pathogens

Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2

(2010) Kai-xin Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

A Double Mutation in Glycoprotein gB Compensates for Ineffective gD-Dependent Initiation of Herpes Simplex Virus Type 1 Infection

(2010) H. Uchida et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus Glycoproteins H/L Bind to Cells Independently of  V 3 Integrin and Inhibit Virus Entry, and Their Constitutive Expression Restricts Infection

(2010) T. Gianni et al.   JOURNAL OF VIROLOGY

Cascade of Events Governing Cell-Cell Fusion Induced by Herpes Simplex Virus Glycoproteins gD, gH/gL, and gB

(2010) D. Atanasiu et al.   JOURNAL OF VIROLOGY

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

(2010) Tirumala K Chowdary et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody

(2010) M. Backovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain

(2009) Tatiana Gianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross Talk among the Glycoproteins Involved in Herpes Simplex Virus Entry and Fusion: the Interaction between gB and gH/gL Does Not Necessarily Require gD

(2009) E. Avitabile et al.   JOURNAL OF VIROLOGY

Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

(2009) L. Menotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entry of herpesviruses into mammalian cells

(2008) E. E. Heldwein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

(2008) L. Menotti et al.   JOURNAL OF VIROLOGY

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY