Article
Immunology
Aditya Arra, Holger Lingel, Mandy Pierau, Monika C. C. Brunner-Weinzierl
Summary: PD-1 plays a crucial role in suppressing the differentiation and function of Tc17 cells, and blockade of PD-1 can effectively enhance tumor immune response. PD-1 signaling inhibits the expression of IL-17 and related transcription factors in Tc17 cells, and also suppresses the expression of IL-21 and IL-23 receptors specific to Tc17 cells. Inhibition of PD-1 leads to the conversion of Tc17 cells into Tc1 cells, which possess tumor control characteristics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jian Hang Lam, Amit K. Khan, Thomas A. Cornell, Teck Wan Chia, Regine J. Dress, Wen Wang William Yeow, Nur Khairiah Mohd-Ismail, Shrinivas Venkataraman, Kim Tien Ng, Yee-Joo Tan, Danielle E. Anderson, Florent Ginhoux, Madhavan Nallani
Summary: This study describes a subunit vaccine based on the SARS-CoV-2 spike protein coadministered with CpG adjuvant, encapsulated with a proprietary artificial cell membrane (ACM) polymersome technology to enhance immunogenicity. In mice experiments, two doses of this formulation elicited robust neutralizing antibody titers that persisted for at least 40 days and produced functional memory CD4(+) and CD8(+) T cells.
Article
Immunology
Gisella Guerrera, Mario Picozza, Silvia D'Orso, Roberta Placido, Marta Pirronello, Alice Verdiani, Andrea Termine, Carlo Fabrizio, Flavia Giannessi, Manolo Sambucci, Maria Pia Balice, Carlo Caltagirone, Antonino Salvia, Angelo Rossini, Luca Battistini, Giovanna Borsellino
Summary: Vaccination with the Pfizer-BioNTech mRNA vaccine induces a sustained anti-viral T cell response for at least 6 months, demonstrating immunological competence and long-term memory against SARS-CoV-2.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Lazaro Moreira Marques-Neto, Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Luciana Cezar de Cerqueira Leite
Summary: The rBCG-LTAK63 vaccine induces a long-term polyfunctional Th1/Th17 response and an increased presence of memory T cells, leading to improved protection against Mycobacterium tuberculosis (Mtb) in mice. This enhanced immune response may contribute to the long-term protection provided by the vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Kristen W. Cohen, Susanne L. Linderman, Zoe Moodie, Julie Czartoski, Lilin Lai, Grace Mantus, Carson Norwood, Lindsay E. Nyhoff, Venkata Viswanadh Edara, Katharine Floyd, Stephen C. De Rosa, Hasan Ahmed, Rachael Whaley, Shivan N. Patel, Brittany Prigmore, Maria P. Lemos, Carl W. Davis, Sarah Furth, James B. O'Keefe, Mohini P. Gharpure, Sivaram Gunisetty, Kathy Stephens, Rustom Antia, Veronika I. Zarnitsyna, David S. Stephens, Srilatha Edupuganti, Nadine Rouphael, Evan J. Anderson, Aneesh K. Mehta, Jens Wrammert, Mehul S. Sulthar, Rafi Ahmed, M. Juliana McElrath
Summary: The study reveals that COVID-19 patients have durable broad-based immune responses, including the continuous generation of antibodies, memory B cells, and polyfunctional T cells, which help to rapidly generate antibody responses against virus re-exposure or vaccination.
CELL REPORTS MEDICINE
(2021)
Review
Immunology
Salome LeibundGut-Landmann
Summary: Fungi are an important component of the mammalian microbiota, colonizing most mucosal surfaces and the skin. The stability of fungal colonization on these surfaces is crucial for preventing dysbiosis and infections. Tissue resident memory T cells play a significant role in protecting the host from pathogens and maintaining a strategic advantage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shuya Mitoma, Brigid Veronica Carr, Yongjie Harvey, Katy Moffat, Satoshi Sekiguchi, Bryan Charleston, Junzo Norimine, Julian Seago
Summary: Foot-and-mouth disease (FMD) is a highly contagious and economically devastating disease for cloven-hooved animals. The study identified CD4(+) T-cell epitopes in the FMD virus capsid and revealed a long-lasting Th1 cell phenotype after FMD vaccination. The presence of FMDV-specific CD4(+) T cells in bovine PBMC more than four years post-vaccination highlights the importance of vaccine-induced adaptive immunity for long-term protection.
Article
Cell Biology
Amanda L. Patchett, Cesar Tovar, Nicholas B. Blackburn, Gregory M. Woods, A. Bruce Lyons
Summary: RNA sequencing of DFT1 tumours in Tasmanian devils revealed different phenotypes under immune pressure, with an 'immune-enriched' phenotype showing upregulation of immune checkpoint molecules. These findings suggest that DFTD cancers utilize mesenchymal plasticity and immune evasion mechanisms similar to human cancers, highlighting the potential for modifying DFTD vaccines.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Shu Ichimiya, Akiko Fujimura, Muneyuki Masuda, Shogo Masuda, Ryuji Yasumatsu, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Poh Yin Yew, Sachiko Yoshimura, Hideya Onishi, Masafumi Nakamura, Yusuke Nakamura, Takashi Morisaki
Summary: The combination therapy of DC vaccine and ICI led to a durable complete response in a patient with refractory metastatic SDC, potentially due to pre-existing neoantigen-specific T cells in peripheral blood before treatment and their stimulation and expansion following treatment.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Microbiology
Som Gowda Nanjappa, Nydiaris Hernandez-Santos, Kevin Galles, Marcel Wuethrich, M. Suresh, Bruce S. Klein
Article
Hematology
Som G. Nanjappa, Eui Ho Kim, M. Suresh
Review
Immunology
Som G. Nanjappa, Bruce S. Klein
CURRENT OPINION IN IMMUNOLOGY
(2014)
Article
Medicine, Research & Experimental
Som G. Nanjappa, Jane H. Walent, Michel Morre, M. Suresh
JOURNAL OF CLINICAL INVESTIGATION
(2008)
Article
Medicine, Research & Experimental
Som G. Nanjappa, Erika Heninger, Marcel Wuethrich, Thomas Sullivan, Bruce Klein
JOURNAL OF CLINICAL INVESTIGATION
(2012)
Article
Immunology
Som G. Nanjappa, Srinivasu Mudalagiriyappa, J. Scott Fites, M. Suresh, Bruce S. Klein
JOURNAL OF IMMUNOLOGY
(2018)
Article
Microbiology
Rene M. Roy, Hugo C. Paes, Som G. Nanjappa, Ron Sorkness, David Gasper, Alana Sterkel, Marcel Wuethrich, Bruce S. Klein
Article
Microbiology
Som Gowda Nanjappa, Erika Heninger, Marcel Wuethrich, David Joseph Gasper, Bruce S. Klein
Article
Microbiology
T. Tristan Brandhorst, Rene Roy, Marcel Wuethrich, Som Nanjappa, Hanna Filutowicz, Kevin Galles, Marco Tonelli, Darrell R. McCaslin, Kenneth Satyshur, Bruce Klein
Article
Agriculture, Dairy & Animal Science
Lorenzo G. T. M. Segabinazzi, Giorgia Podico, Michael F. Rosser, Som G. Nanjappa, Marco A. Alvarenga, Igor F. Canisso
Summary: Platelet-rich plasma (PRP) is a popular therapy in human and veterinary medicine, and this study compared three manual noncommercial methods for preparing PRP and its cooling effects. The different methods yielded varying platelet concentrations and viability, while cooling increased platelet agglutination over time. It remains uncertain whether these differences in preparation methods and cooling would impact the clinical efficacy of PRP.
Article
Virology
Fangfeng Yuan, Jaishree Sharma, Som G. Nanjappa, Christopher A. Gaulke, Ying Fang
Summary: This study investigates the effects of a killed virus vaccine on the gut microbiome diversity in pigs and finds significant interaction effects between viral challenge and vaccination on the gut microbiota. The vaccine only partially protects the gut microbiome from viral impacts, and the abundances of certain microbial taxa are correlated with viral load levels and specific cell counts.
Article
Oncology
Liqian Ma, Lawrence Wang, Adam T. Nelson, Chaeyeon Han, Sisi He, Madeline A. Henn, Karan Menon, Joy J. Chen, Amy E. Baek, Anna Vardanyan, Sayyed Hamed Shahoei, Sunghee Park, David J. Shapiro, Som G. Nanjappa, Erik R. Nelson
Article
Immunology
Mohammed Shamim, Som G. Nanjappa, Anju Singh, Erin Hemmila Plisch, Scott E. LeBlanc, Jane Walent, John Svaren, Christine Seroogy, M. Suresh
JOURNAL OF IMMUNOLOGY
(2007)