ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction

Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation

(2015) Jae-Min Yuk et al.   IMMUNITY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)

(2015) Ivan Casaburi et al.   Oncotarget

Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?

(2014) T. Seijkens et al.   DIABETES

Downregulation of MicroRNA miR-526a by Enterovirus Inhibits RIG-I-Dependent Innate Immune Response

(2014) C. Xu et al.   JOURNAL OF VIROLOGY

Estrogen-related receptor α is required for efficient human cytomegalovirus replication

(2014) Jesse Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration

(2014) Juliette Sailland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer

(2014) Congwen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon

(2014) Feng Ma et al.   Nature Communications

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

(2013) Cédric Chaveroux et al.   Cell Metabolism

NLRP3 and IL-1βin macrophages as critical regulators of metabolic diseases

(2013) A. F. McGettrick et al.   DIABETES OBESITY & METABOLISM

Mechanism of Endogenous Regulation of the Type I Interferon Response by Suppressor of IκB Kinase ϵ (SIKE), a Novel Substrate of TANK-binding Kinase 1 (TBK1)

(2013) James D. Marion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Metabolism Generates Signals during Innate Immunity and Inflammation

(2013) Anne F. McGettrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Loss of estrogen-related receptor   promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances

(2013) E.-J. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

Estrogen-related receptor α regulates osteoblast differentiation via Wnt/β-catenin signaling

(2012) Kathryn L Auld et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

The PGC-1/ERR signaling axis in cancer

(2012) G Deblois et al.   ONCOGENE

Crosstalk between reverse cholesterol transport and innate immunity

(2012) Kathleen M. Azzam et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dual Function of ERR  in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin

(2011) A. Fradet et al.   CANCER RESEARCH

MIP-T3 Is a Negative Regulator of Innate Type I IFN Response

(2011) M.-H. J. Ng et al.   JOURNAL OF IMMUNOLOGY

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs

(2011) Catherine R. Dufour et al.   PLoS Genetics

Estrogen-related receptor α and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria

(2010) Delphine Mirebeau-Prunier et al.   FEBS Journal

Glycogen Synthase Kinase 3β Regulates IRF3 Transcription Factor-Mediated Antiviral Response via Activation of the Kinase TBK1

(2010) Cao-Qi Lei et al.   IMMUNITY

TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases

(2010) Kislay Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Negatively Regulates IFN-β Production in Toll-like Receptor (TLR) 3- and TLR4-stimulated Macrophages by Preventing Interferon Regulatory Factor 3 Binding to the IFN-β Promoter

(2010) Wei Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Involvement of the orphan nuclear estrogen receptor-related receptor α in osteoclast adhesion and transmigration

(2010) Edith Bonnelye et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition

(2010) J. R. Flammer et al.   MOLECULAR AND CELLULAR BIOLOGY

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

c-Abl regulates estrogen receptor α transcription activity through its stabilization by phosphorylation

(2010) X He et al.   ONCOGENE

Innate immunity and adipose tissue biology

(2010) Andreas Schäffler et al.   TRENDS IN IMMUNOLOGY

Genome-Wide Identification of Direct Target Genes Implicates Estrogen-Related Receptor   as a Determinant of Breast Cancer Heterogeneity

(2009) G. Deblois et al.   CANCER RESEARCH

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

(2009) Chen Wang et al.   NATURE IMMUNOLOGY

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Communication between the ERRα Homodimer Interface and the PGC-1α Binding Surface via the Helix 8–9 Loop

(2008) Holger Greschik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors

(2008) A. Ao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERRα: a metabolic function for the oldest orphan

(2008) Josep A. Villena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM