Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters

(2015) Alexandre Brodovitch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1

(2014) H. A. Wasserman et al.   JOURNAL OF IMMUNOLOGY

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

(2014) B. B. Au-Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes

(2013) Corine Bronke et al.   AIDS

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system

(2013) Baoyu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells

(2013) F. Raczkowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology

(2012) Carolyn G. King et al.   IMMUNITY

Improving T cell responses to modified peptides in tumor vaccines

(2012) Jonathan D. Buhrman et al.   IMMUNOLOGIC RESEARCH

Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics

(2012) Kristen M. Rosenthal et al.   PLoS One

Insights into T Cell Recognition of Antigen: Significance of Two-Dimensional Kinetic Parameters

(2012) Lindsay J. Edwards et al.   Frontiers in Immunology

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treating cancer with genetically engineered T cells

(2011) Tristen S. Park et al.   TRENDS IN BIOTECHNOLOGY

Stimulation of Naive CD8 + T Cells by a Variant Viral Epitope Induces Activation and Enhanced Apoptosis

(2010) Rebecca M. Ream et al.   JOURNAL OF IMMUNOLOGY

Adaptive Interactions between HLA and HIV-1: Highly Divergent Selection Imposed by HLA Class I Molecules with Common Supertype Motifs

(2010) M. John et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

CD8+ T Cell Responses to a Viral Escape Mutant Epitope: Active Suppression via Altered SHP-1 Activity

(2009) F. J. Schnell et al.   JOURNAL OF IMMUNOLOGY

Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection

(2009) J. N. Blattman et al.   JOURNAL OF VIROLOGY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

CD4+ T Cell-Derived IL-2 Signals during Early Priming Advances Primary CD8+ T Cell Responses

(2009) Yo-Ping Lai et al.   PLoS One

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The good, the bad and the ugly: how altered peptide ligands modulate immunity

(2008) Maria Katsara et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY