Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress

(2017) Deepak Kumar Deep et al.   PLoS Neglected Tropical Diseases

The F0F1ATP Synthase Complex Localizes to Membrane Rafts in Gonadotrope Cells

(2016) Krystal Allen-Worthington et al.   MOLECULAR ENDOCRINOLOGY

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling

(2015) Consuelo Gajate et al.   APOPTOSIS

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

(2015) C. Gajate et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Decline in Clinical Efficacy of Oral Miltefosine in Treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in India

(2015) V. Ramesh et al.   PLoS Neglected Tropical Diseases

Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel

(2015) Edward Yepes et al.   PLoS Neglected Tropical Diseases

Editorial (Thematic Issue: Antitumor Alkylphospholipid Analogs: A Promising and Growing Family of Synthetic Cell Membrane-Targeting Molecules for Cancer Treatment)

(2014) Faustino Mollinedo   Anti-Cancer Agents in Medicinal Chemistry

Lipid Rafts, Endoplasmic Reticulum and Mitochondria in the Antitumor Action of the Alkylphospholipid Analog Edelfosine

(2014) Consuelo Gajate et al.   Anti-Cancer Agents in Medicinal Chemistry

Miltefosine Increases Lipid and Protein Dynamics in Leishmania amazonensis Membranes at Concentrations Similar to Those Needed for Cytotoxicity Activity

(2014) Rodrigo Alves Moreira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis

(2014) Pierre Abramowski et al.   JOURNAL OF NEUROIMMUNOLOGY

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani

(2014) Arpita Kulshrestha et al.   PARASITOLOGY RESEARCH

The Orally Available, Synthetic Ether Lipid Edelfosine Inhibits T Cell Proliferation and Induces a Type I Interferon Response

(2014) Pierre Abramowski et al.   PLoS One

Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy

(2014) J. P. Weichert et al.   Science Translational Medicine

Cell surface F1/Fo ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues

(2013) Yoshiko Kawai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

(2013) Suman Rijal et al.   CLINICAL INFECTIOUS DISEASES

Drug Uptake, Lipid Rafts, and Vesicle Trafficking Modulate Resistance to an Anticancer Lysophosphatidylcholine Analogue in Yeast

(2013) Álvaro Cuesta-Marbán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis

(2013) Wen-juan Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Edelfosine and Miltefosine Effects on Lipid Raft Properties: Membrane Biophysics in Cell Death by Antitumor Lipids

(2013) Bruno M. Castro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma

(2013) M Reis-Sobreiro et al.   Blood Cancer Journal

Efficacy of Miltefosine in the Treatment of Visceral Leishmaniasis in India After a Decade of Use

(2012) S. Sundar et al.   CLINICAL INFECTIOUS DISEASES

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Exogenous Ether Lipids Predominantly Target Mitochondria

(2012) Lars Kuerschner et al.   PLoS One

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

In Vitro and In Vivo Efficacy of Ether Lipid Edelfosine against Leishmania spp. and SbV-Resistant Parasites

(2012) Rubén E. Varela-M et al.   PLoS Neglected Tropical Diseases

Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum

(2011) C Gajate et al.   ONCOGENE

Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

(2011) F Mollinedo et al.   Cell Death & Disease

Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment

(2010) Zhan Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Potential involvement of F0F1-ATP(synth)ase and reactive oxygen species in apoptosis induction by the antineoplastic agent erucylphosphohomocholine in glioblastoma cell lines

(2010) Leo Veenman et al.   APOPTOSIS

In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts

(2010) F. Mollinedo et al.   CLINICAL CANCER RESEARCH

Leishmania tarentolae: Utility as an in vitro model for screening of antileishmanial agents

(2010) Viviana M. Taylor et al.   EXPERIMENTAL PARASITOLOGY

Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane

(2010) Bong-Woo Kim et al.   Expert Review of Proteomics

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy

(2010) Faustino Mollinedo et al.   Future Oncology

Selective Fusion of Azurophilic Granules withLeishmania-containing Phagosomes in Human Neutrophils

(2010) Faustino Mollinedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid raft-targeted therapy in multiple myeloma

(2010) F Mollinedo et al.   ONCOGENE

Lipid raft connection between extrinsic and intrinsic apoptotic pathways

(2009) Consuelo Gajate et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antitumor Alkyl Ether Lipid Edelfosine: Tissue Distribution and Pharmacokinetic Behavior in Healthy and Tumor-Bearing Immunosuppressed Mice

(2009) A. E.-H. de Mendoza et al.   CLINICAL CANCER RESEARCH

Leishmania (Viannia) panamensis: An in vitro assay using the expression of GFP for screening of antileishmanial drug

(2009) Rubén E. Varela M et al.   EXPERIMENTAL PARASITOLOGY

Membrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes

(2009) M. Saint-Pierre-Chazalet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Macrophage NADPH Oxidase Flavocytochrome b Localizes to the Plasma Membrane and Rab11-Positive Recycling Endosomes

(2009) A.-J. Casbon et al.   JOURNAL OF IMMUNOLOGY

IL-17 Promotes Progression of Cutaneous Leishmaniasis in Susceptible Mice

(2009) S. Lopez Kostka et al.   JOURNAL OF IMMUNOLOGY

Novel Anti-Inflammatory Action of Edelfosine Lacking Toxicity with Protective Effect in Experimental Colitis

(2009) F. Mollinedo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Involvement of Raft Aggregates Enriched in Fas/CD95 Death-Inducing Signaling Complex in the Antileukemic Action of Edelfosine in Jurkat Cells

(2009) Consuelo Gajate et al.   PLoS One

Edelfosine Is Incorporated into Rafts and Alters Their Organization

(2008) Alessio Ausili et al.   JOURNAL OF PHYSICAL CHEMISTRY B