The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

(2016) Christina McGuire et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

TOR Complexes and the Maintenance of Cellular Homeostasis

(2016) Sandra Eltschinger et al.   TRENDS IN CELL BIOLOGY

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

(2016) Katie Powis et al.   Cell Discovery

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence

(2016) Martin Weinberger et al.   Aging-US

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

(2015) Laura A. Stransky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The yeast Saccharomyces cerevisiae: An overview of methods to study autophagy progression

(2015) Elizabeth Delorme-Axford et al.   METHODS

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

(2015) James E Hughes Hallett et al.   eLife

Interplay among Gcn5, Sch9 and Mitochondria during Chronological Aging of Wine Yeast Is Dependent on Growth Conditions

(2015) Cecilia Picazo et al.   PLoS One

A Dynamic Interface between Vacuoles and Mitochondria in Yeast

(2014) Yael Elbaz-Alon et al.   DEVELOPMENTAL CELL

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

(2014) Carina Hönscher et al.   DEVELOPMENTAL CELL

Saccharomyces cerevisiae Vacuolar H+-ATPase Regulation by Disassembly and Reassembly: One Structure and Multiple Signals

(2014) Karlett J. Parra et al.   EUKARYOTIC CELL

Endolysosomal Membrane Trafficking Complexes Drive Nutrient-Dependent TORC1 Signaling to Control Cell Growth inSaccharomyces cerevisiae

(2014) Joanne M. Kingsbury et al.   GENETICS

Roles for PI(3,5)P2 in nutrient sensing through TORC1

(2014) Natsuko Jin et al.   MOLECULAR BIOLOGY OF THE CELL

The signaling lipid PI(3,5)P2 stabilizes V1–Vo sector interactions and activates the V-ATPase

(2014) Sheena Claire Li et al.   MOLECULAR BIOLOGY OF THE CELL

Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity

(2014) Reinhard Dechant et al.   MOLECULAR CELL

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension

(2013) Jessica Stephan et al.   AGING CELL

Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation inSaccharomyces cerevisiae

(2013) Erwin Swinnen et al.   FEMS YEAST RESEARCH

Autophagic Processes in Yeast: Mechanism, Machinery and Regulation

(2013) F. Reggiori et al.   GENETICS

The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast

(2013) Anne M. Smardon et al.   MOLECULAR BIOLOGY OF THE CELL

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae

(2013) Erwin Swinnen et al.   MOLECULAR BIOLOGY OF THE CELL

Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity

(2013) Ziyun Wu et al.   PLoS One

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

(2012) Belém Sampaio-Marques et al.   Autophagy

Transient Sequestration of TORC1 into Stress Granules during Heat Stress

(2012) Terunao Takahara et al.   MOLECULAR CELL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pHc in Saccharomyces cerevisiae

(2012) Rick Orij et al.   GENOME BIOLOGY

Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction

(2011) Jin-Ying Lu et al.   CELL

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

(2011) Alexandre Huber et al.   EMBO JOURNAL

Consequences of Loss of Vph1 Protein-containing Vacuolar ATPases (V-ATPases) for Overall Cellular pH Homeostasis

(2011) Maureen Tarsio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Orthologs Pkh1–3 Differentially Regulate Phosphorylation of Protein Kinase A (PKA) and the Protein Kinase B (PKB)/S6K Ortholog Sch9

(2011) Karin Voordeckers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae

(2011) Gregory C. Finnigan et al.   MOLECULAR BIOLOGY OF THE CELL

Composition and Acidification of the Culture Medium Influences Chronological Aging Similarly in Vineyard and Laboratory Yeast

(2011) Christopher J. Murakami et al.   PLoS One

Nutrient Sensing Kinases PKA and Sch9 Phosphorylate the Catalytic Domain of the Ubiquitin-Conjugating Enzyme Cdc34

(2011) Ross Cocklin et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

The N-terminal domain of the V-ATPase subunit 'a' is regulated by pH in vitro and in vivo

(2010) Reinhard Dechant et al.   Channels

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

(2010) Bart Smets et al.   CURRENT GENETICS

Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase

(2010) Reinhard Dechant et al.   EMBO JOURNAL

The Cvt pathway as a model for selective autophagy

(2010) Melinda A. Lynch-Day et al.   FEBS LETTERS

Regulation of Vacuolar Proton-translocating ATPase Activity and Assembly by Extracellular pH

(2010) Theodore T. Diakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates

(2010) Alexandre Soulard et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism

(2010) B. P. Young et al.   SCIENCE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Autophagy and amino acid homeostasis are required for chronological longevity inSaccharomyces cerevisiae

(2009) Ashley L. Alvers et al.   AGING CELL

Phosphatidylinositol 3-Kinase-dependent Activation of Mammalian Protein Kinase B/Akt inSaccharomyces cerevisiae, anin VivoModel for the Functional Study of Akt Mutations

(2009) Isabel Rodríguez-Escudero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth

(2009) R. Orij et al.   MICROBIOLOGY-SGM

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Sfp1 Interaction with TORC1 and Mrs6 Reveals Feedback Regulation on TOR Signaling

(2009) Harri Lempiäinen et al.   MOLECULAR CELL

Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae

(2009) Sandra Merz et al.   GENOME BIOLOGY

Protein Kinase B/Akt Phosphorylates and Inhibits the Cardiac Na +/ H + Exchanger NHE1

(2008) Andrew K. Snabaitis et al.   CIRCULATION RESEARCH

Increased Respiration in thesch9ΔMutant Is Required for Increasing Chronological Life Span but Not Replicative Life Span

(2008) Hugo Lavoie et al.   EUKARYOTIC CELL

Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9

(2008) Bart Smets et al.   FEMS YEAST RESEARCH

The Ras/cAMP/Protein Kinase A Pathway Regulates Glucose-dependent Assembly of the Vacuolar (H+)-ATPase in Yeast

(2008) Sarah Bond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY