Article
Pharmacology & Pharmacy
Chen Ning, Shengdi Su, Jiaming Li, Dexuan Kong, Hui Cai, Zhiying Qin, Han Xing, Xijing Chen, Jiake He
Summary: The study identified the impact of clopidogrel and its metabolite on the transport of rosuvastatin, potentially leading to hepatotoxicity. The findings suggest that clopidogrel can affect the metabolism and efficacy of rosuvastatin by inhibiting the transmembrane transport proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anne T. Nies, Joerg Koenig, Ute Hofmann, Charlotte Koelz, Martin F. Fromm, Matthias Schwab
Summary: Remdesivir has been approved for COVID-19 treatment, but the study indicates that OATP1B1 and its genetic variants, OATP1B3, OATP2B1 and OCT1, are not relevant for the hepatic uptake of the drug in humans. This suggests that there are no clinically relevant transporter-mediated drug interactions expected due to the rapid clearance of remdesivir.
Article
Food Science & Technology
Shanoo Suroowan, Hassan Hadi Abdallah, Mohamad Fawzi Mahomoodally
Summary: Herbal and conventional medicine combination can be potentially dangerous, leading to perilous herb-drug interactions and toxicity. Different plant species have different pharmacological properties, and should not be mixed with drugs having the same properties. Herbal medicines should be used at low doses for a short period of time and under the supervision of healthcare professionals to avoid potential adverse and toxic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Neurosciences
Tram T. Le, Sarah R. McGrath, Pius S. Fasinu
Summary: The use of herbal products as complementary medicine alongside prescription neuropsychiatric drugs is common, but it can lead to herb-drug interactions that may jeopardize the success of pharmacotherapy. This study identified 13 commonly used herbal products that have clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders, emphasizing the importance of caution in herb-drug co-medication.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Immunology
Emiel Leegwater, Anne Strik, Erik B. Wilms, Liesbeth B. E. Bosma, David M. Burger, Thomas H. Ottens, Cees van Nieuwkoop
Summary: In this case report, a COVID-19 patient developed acute hepatotoxicity related to remdesivir, possibly due to the interaction with P-glycoprotein (P-gp) inhibitors. It is recommended that physicians exercise caution when prescribing P-gp inhibitors to patients receiving remdesivir therapy, until more information on this interaction is available.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Toxicology
Guillermo Quintas, Teresa Martinez-Sena, Isabel Conde, Eugenia Pareja Ibars, Jos Kleinjans, Jose Castell
Summary: DILI, an adverse toxic reaction associated with drug administration, is currently classified based on ALT and ALP values, but lacks accuracy. By integrating metabolomic information, a more accurate evaluation of DILI phenotypes can be achieved.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Debra Wu, Douglas Vogus, Vinu Krishnan, Marta Broto, Anusha Pusuluri, Zongmin Zhao, Neha Kapate, Samir Mitragotri
Summary: The study introduced a prodrug 5FUR-W for improved loading in liposomes, showing significant anti-tumor effects in a breast cancer model.
Article
Medicine, General & Internal
Kartikeya Murari, Abdulrahman Abushaibah, Jong M. Rho, Ray W. Turner, Ning Cheng
Summary: The selective inhibitor PD325901 was found to successfully reduce core pathological deficits in the BTBR mouse model of autism, including impaired sociability, vocalization, and repetitive behavior, and restored abnormal EEG signals. These results further support the critical involvement of the ERK pathway in the pathophysiology of autism and suggest that a similar approach could be applied to other animal models with dysregulated ERK signaling.
Review
Cell Biology
Silvia Bressan, Alessandra Pierantoni, Saman Sharifi, Sergio Facchini, Vincenzo Quagliarello, Massimiliano Berretta, Monica Montopoli
Summary: HIV patients have increased risk of developing cancer and treating those with both HIV and cancer can be complicated due to the risk of drug-drug interactions. Temporary discontinuation of ART may be a strategy to manage the risk of DDIs.
Article
Infectious Diseases
Joachim Andreas Koeck, Heike Hilgarth, Andreas von Ameln-Mayerhofer, Damaris Meyn, Ruediger Warlich, Andreas Muenstedt, Dagmar Horn, Christina Koenig
Summary: ICU patients are at high risk of drug-drug interactions due to polypharmacy, but little is known about the type and frequency of DDIs within German ICUs. Clinical pharmacists' interventions in a national database were filtered for ICU patients, and a Delphi process was employed to evaluate and develop guidance for clinical practice. Most DDIs involved macrolides, antifungals, or fluoroquinolones, highlighting the need for inter-professional discussion in managing DDIs for individual patients.
Article
Pharmacology & Pharmacy
David Haefliger, Catia Marzolini, Frederic Lamoth, Thomas Pabst, Thierry Buclin, Francoise Livio
Summary: In patients with leukemia, Midostaurin is frequently used together with azole antifungals for the prevention or treatment of aspergillosis. Midostaurin is extensively metabolized by CYP3A4 and can inhibit and induce various CYP enzymes at therapeutic concentrations. Therefore, Midostaurin has a high potential for drug-drug interactions, both as a substrate and as a perpetrator.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Sock Hoai Chan, Yasmin Bylstra, Jing Xian Teo, Jyn Ling Kuan, Nicolas Bertin, Mar Gonzalez-Porta, Maxime Hebrard, Roberto Tirado-Magallanes, Joanna Hui Juan Tan, Justin Jeyakani, Zhihui Li, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Eleanor Wong, Tien Yin Wong, Shyam Prabhakar, Jianjun Liu, Ching-Yu Cheng, Birgit Eisenhaber, Neerja Karnani, Khai Pang Leong, Xueling Sim, Khung Keong Yeo, John C. Chambers, E-Shyong Tai, Patrick Tan, Saumya S. Jamuar, Joanne Ngeow, Weng Khong Lim
Summary: This study characterizes the clinically significant genetic variation in Asian populations and reveals the diverse genetic risk burden attributable to ancestry-specific variants. It also identifies individuals with variants discordant to their self-reported ethnicity, possibly due to cryptic admixture. Additionally, the study highlights the presence of pharmaceutical genetic variants in a significant proportion of Asians.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Libin Song, Simin Qi, Wei Hu, Zhixiao Fang, Dehua Yu, Teng Liu, Jingni Wu, Yangjun Wu, Aiwei Wu, Lanyun Feng, Jing Xie, Bo Zhang, Wenguang He, Zhouyu Ning, Luming Liu, Jiang-Jiang Qin, Shengli Li
Summary: Pancreatic cancer cell lines were classified into two subgroups based on transcriptomic mRNA expression, with distinct protein profiles and differential proteins involved in specific signaling pathways. Patients in different subgroups exhibited varying clinical outcomes and drug sensitivities, suggesting potential for precision treatments based on molecular characteristics.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Medicinal
Mariana Sipos, Andreea Farcas, Daniel Corneliu Leucuta, Camelia Bucsa, Madalina Huruba, Cristina Mogosan
Summary: This study aimed to characterize individual case safety reports (ICSRs) and adverse drug reactions (ADRs) related to second-generation cephalosporins that led to hepatobiliary disorders, in the global VigiBase database. The analysis included 1343 ICSRs containing 1585 ADRs, with Cefuroxime being the suspected culprit in most cases. ADR outcomes were favorable for 49% of the elderly and 51% of the adult population, with cholestatic hepatitis being predominantly reported in the elderly.
Article
Pharmacology & Pharmacy
Khan Mohammad Imran, Benjamin Tintera, Holly A. A. Morrison, Juselyn D. D. Tupik, Margaret A. A. Nagai-Singer, Hannah Ivester, McAlister Council-Troche, Michael Edwards, Sheryl Coutermarsh-Ott, Christopher Byron, Sherrie Clark-Deener, Kyungjun Uh, Kiho Lee, Paul Boulos, Cliff Rowe, Christian Coviello, Irving C. C. Allen
Summary: Pancreatic tumors can be resistant to drug penetration. The emerging technology of ultrasound-induced cavitation combined with gas-stabilizing sub-micron scale SonoTran Particles has shown potential to overcome this limitation. In this study, large animal models of pancreatic cancer were used to evaluate the effectiveness of this approach, and results showed that ultrasound-mediated cavitation significantly improved therapeutic delivery in pancreatic tumors.
Article
Biotechnology & Applied Microbiology
Kyra Hoffmann, Birthe Halmschlag, Simon Briel, Michaela Sieben, Sastia Putri, Eiichiro Fukusaki, Lars M. Blank, Jochen Buechs
Summary: In this study, the ViMOS system was used to monitor the production and degradation of gamma-PGA in shake flasks. The P-pst promoter was found to be activated under phosphate starvation, and a triple knockout mutant showed a significant increase in gamma-PGA yield compared to the reference strain. The online measured data were confirmed with offline measurements, demonstrating the potential of ViMOS to provide detailed and reliable information for optimizing gamma-PGA production.
BIOTECHNOLOGY PROGRESS
(2023)
Article
Biotechnology & Applied Microbiology
Jana Fees, Jonas J. Christ, Sabine Willbold, Lars M. Blank
Summary: A biotechnological process using Saccharomyces cerevisiae to upgrade phosphate-containing wastewater into pure sodium polyphosphate was developed in this study. The quality of polyphosphate was independent of the composition of the wash water and can be reused in various applications, contributing to the sustainable utilization of phosphate and reducing the need for phosphate rock.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Patrick Bongartz, Tobias Karmainski, Moritz Meyer, John Linkhorst, Till Tiso, Lars M. Blank, Matthias Wessling
Summary: Bioreactors play a crucial role in the production of biopharmaceuticals, biomaterials, and sustainable substitutes for chemicals. However, the traditional aeration technique used in bioreactors has limitations such as shear stress, foaming, and sterility concerns. This study presents a membrane stirrer (MemStir) that combines simulations and experiments, providing efficient bubble-free aeration. The MemStir demonstrated excellent performance in a foam-free recombinant production process, delivering high oxygen transfer rates and demonstrating its potential for various applications including animal cell cultivation.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Gastroenterology & Hepatology
Josefin Soppert, Elisa Fabiana Brandt, Nicole Maria Heussen, Emona Barzakova, Lars Mathias Blank, Lars Kuepfer, Mathias Walter Hornef, Jonel Trebicka, Joachim Jankowski, Marie -Luise Berres, Heidi Noels
Summary: This study provides evidence that blood endotoxin levels are associated with gut permeability and disease stage in patients with NAFLD. Blood endotoxin levels can serve as a diagnostic biomarker for NAFLD and can be used for staging during disease progression.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Agriculture, Multidisciplinary
Shangkun Qiu, Lars M. Blank
Summary: Plant natural products are valuable resources for novel chemical structures, but their extraction often leads to high prices, fluctuation in quantity and quality, and negative environmental impact. Synthetic biology allows for large-scale production of these natural products using yeasts as hosts. This article focuses on the recent advancements in metabolic engineering of Saccharomyces cerevisiae and Yarrowia lipolytica for the synthesis of ginsenoside triterpenoids, discussing synthetic biology, bioprocess strategies, and current challenges. Future directions in metabolic and process engineering for sustainable ginsenoside production are also summarized.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Lorenzo Fabbri, Ronan Garlantezec, Karine Audouze, Mariona Bustamante, Angel Carracedo, Leda Chatzi, Juan Ramon Gonzalez, Regina Grazuleviciene, Hector Keun, Chung-Ho E. Lau, Eduard Sabido, Alexandros P. Siskos, Remy Slama, Cathrine Thomsen, John Wright, Wen Lun Yuan, Maribel Casas, Martin Vrijheid, Lea Maitre
Summary: This study aimed to identify multi-omic signatures associated with childhood exposure to non-persistent endocrine disrupting chemicals (EDCs). By using a repeated sampling strategy and integrating multiple omics data, a total of 950 reproducible associations were found, including 23 direct associations between EDCs and omics. These associations can help us understand the effects of EDCs on neurological and metabolic outcomes.
ENVIRONMENT INTERNATIONAL
(2023)
Correction
Biochemical Research Methods
Hao Guo, Huiyan Wang, Tongtong Chen, Liwei Guo, Lars M. Blank, Birgitta E. Ebert, Yi-Xin Huo
ACS SYNTHETIC BIOLOGY
(2023)
Article
Microbiology
Difan Xiao, Lars M. Blank, Till Tiso
Summary: This article discusses the versatility of the black-yeast-like Aureobasidium as a cell factory for various biotechnological applications. It describes the draft genome sequence of Aureobasidium pullulans NRRL 62031, isolated in Thailand, which spans 25.05-Mb. The genome sequence reveals numerous synthesis pathways for valuable secondary metabolites.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Biochemical Research Methods
Anna Lipphardt, Tobias Karmainski, Lars M. Blank, Heiko Hayen, Till Tiso
Summary: A novel biosurfactant synthesized by the marine bacterium Alcanivorax borkumensis has been discovered, which enhances the bacterium's attachment to oil droplets and facilitates the uptake of hydrocarbons. A method combining HPLC with HRMS has been developed to separate and identify the biosurfactant, and charged-aerosol detection (CAD) enables absolute quantification without authentic standards. The biosurfactant production by A. borkumensis using different carbon sources has been investigated, and various congeners with different chain lengths and degrees of unsaturation have been identified. Hexadecane was found to result in a higher titer of biosurfactant compared to pyruvate. The analytical method presented allows for the identification, characterization, and quantification of complex and varying glycolipids.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Niki Baccile, Alexandre Poirier, Javier Perez, Petra Pernot, Daniel Hermida-Merino, Patrick Le Griel, Christian C. Blesken, Conrad Mu''ller, Lars M. Blank, Till Tiso
Summary: The structure-property relationship of rhamnolipids, a type of microbial biosurfactants, is investigated using cryo-TEM and SAXS. The self-assembly behavior of different rhamnolipids and a rhamnose-free fatty acid in water at various pH values is studied. Micellar structures are found for RhaC10 and RhaRhaC10C10, while RhaC10C10 undergoes a micelle-to-vesicle transition at pH 6.5. The hydrophobic core radius, hydrophilic shell thickness, aggregation number, and surface area per rhamnolipid are estimated using modeling and SAXS data fitting. The packing parameter model explains the observed micellar morphology but fails to explain the lamellar phase of protonated RhaRhaC10C10 at acidic pH.
Article
Clinical Neurology
Ruijia Chen, Marie-Laure Charpignon, Rafeya V. Raquib, Jingxuan Wang, Erika Meza, Helene E. Aschmann, Michelle A. DeVost, Alyssa Mooney, Kirsten Bibbins-Domingo, Alicia R. Riley, Mathew V. Kiang, Yea-Hung Chen, Andrew C. Stokes, M. Maria Glymour
Summary: This study compares excess deaths associated with Alzheimer's disease or related dementias during the COVID-19 pandemic between year 1 and year 2. The study examines the overall situation and breaks it down by age, sex, race and ethnicity, and place of death. Deaths associated with Alzheimer's disease increased significantly in the first year of the pandemic, but it is unclear whether the mortality declined in the second year when better prevention strategies and vaccines were available.
Article
Multidisciplinary Sciences
Bastian Kister, Alina Viehof, Ulrike Rolle-Kampczyk, Annika Schwentker, Nicole Simone Treichel, Susan A. V. Jennings, Theresa H. Wirtz, Lars M. Blank, Mathias W. Hornef, Martin von Bergen, Thomas Clavel, Lars Kuepfer
Summary: The study developed a mouse model of bile acid metabolism to understand the relationship between altered bile acid metabolism and related diseases. The model accurately described the synthesis, transformation, distribution, and excretion of bile acids in mice. It can be used to analyze the functional aspects of bile acid metabolism and translate results from mouse studies to clinical relevance through cross-species extrapolation.
Review
Agriculture, Multidisciplinary
Shangkun Qiu, Lars M. Blank
Summary: Plant natural products are a valuable source of novel chemical structures. However, their extraction can be expensive and result in fluctuation in quantity and quality, as well as negative environmental impact. Synthetic biology has enabled the production of natural plant products using yeasts as hosts.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Carolin Grutering, Tobias Harhues, Fabian Speen, Robert Keller, Martin Zimmermann, Peter R. Jensen, Matthias Wessling, Lars M. Blank
Summary: This study demonstrates the efficient production of enantiopure (3R)-acetoin using genetically modified Lactococcus lactis in dilute resting cell buffer, followed by electrochemical conversion to 2-butanone. The electrocatalysis using resting cell broth as the electrolyte achieved a higher 2-butanone yield compared to previous studies and synthesis from complex media fermentation supernatants.
Article
Biotechnology & Applied Microbiology
Anita L. Ziegler, Carolin Gruetering, Leon Poduschnick, Alexander Mitsos, Lars M. Blank
Summary: By combining computational and experimental work, we demonstrate that feeding ethanol in addition to glucose improves the yield of biotechnologically produced methyl ketones.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2023)