A clinically relevant selective ERK-pathway inhibitor reverses core deficits in a mouse model of autism

Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial

(2021) Elizabeth M. Berry-Kravis et al.   NATURE MEDICINE

Rethinking Stereotypies in Autism

(2021) Meredith J. McCarty et al.   Seminars in Pediatric Neurology

MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders

(2021) Sarah C. Borrie et al.   Molecular Autism

A ketogenic diet affects brain volume and metabolome in juvenile mice

(2021) Shyamchand Mayengbam et al.   NEUROIMAGE

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

(2021) Anne-Kathrin Lutz et al.   Frontiers in Molecular Neuroscience

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

(2021) Haiying Liu et al.   Neurobiology of Stress

OSERR: an open-source standalone electrophysiology recording system for rodents

(2020) Ning Cheng et al.   Scientific Reports

Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice

(2019) Zi-Jun Wang et al.   MOLECULAR PSYCHIATRY

DeepSqueak: a deep learning-based system for detection and analysis of ultrasonic vocalizations

(2019) Kevin R. Coffey et al.   NEUROPSYCHOPHARMACOLOGY

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism

(2019) Eleonora Rosina et al.   Translational Psychiatry

GeneAnalytics Pathways and Profiling of Shared Autism and Cancer Genes

(2019) Alexander Gabrielli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

(2019) Jaume Forés-Martos et al.   Molecular Autism

A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex

(2019) Iris E. Overwater et al.   NEUROLOGY

Getting to the Cores of Autism

(2019) Lilia M. Iakoucheva et al.   CELL

Repetitive Behavior Severity as an Early Indicator of Risk for Elevated Anxiety Symptoms in Autism Spectrum Disorder

(2019) Danielle A. Baribeau et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Conceptual, Regulatory and Strategic Imperatives in the Early Days of EEG-Based Biomarker Validation for Neurodevelopmental Disabilities

(2019) Joshua B. Ewen et al.   Frontiers in Integrative Neuroscience

Precocious myelination in a mouse model of autism

(2019) Maryam Khanbabaei et al.   Translational Psychiatry

Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice

(2018) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome

(2018) Jonathan W. Lovelace et al.   NEUROBIOLOGY OF DISEASE

Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

(2018) Christina Gross et al.   NEUROPSYCHOPHARMACOLOGY

Autism spectrum disorder

(2018) Catherine Lord et al.   LANCET

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome

(2018) Hyeong-Min Lee et al.   Molecular Autism

Discovering translational biomarkers in neurodevelopmental disorders

(2018) Mustafa Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome

(2017) Jun Wang et al.   Journal of Neurodevelopmental Disorders

MUPET—Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic Vocalizations

(2017) Maarten Van Segbroeck et al.   NEURON

The BTBR mouse model of idiopathic autism – Current view on mechanisms

(2017) K.Z. Meyza et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders

(2017) Ileena Mitra et al.   PLoS Genetics

Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders

(2017) Darcy A. Krueger et al.   Annals of Clinical and Translational Neurology

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

(2017) Mark E. Gurney et al.   Scientific Reports

Disruption of visual circuit formation and refinement in a mouse model of autism

(2016) Ning Cheng et al.   Autism Research

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub

(2016) Katherine D. Blizinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice

(2016) Kirsty Sawicka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

(2016) Jacqueline N. Crawley et al.   TRENDS IN GENETICS

Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors

(2016) Alessandro Papale et al.   eLife

PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome

(2015) C. H. Choi et al.   JOURNAL OF NEUROSCIENCE

The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

(2015) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

(2015) J L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism

(2015) Jacob Ellegood et al.   Neurotherapeutics

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1

(2015) Edwin Jousma et al.   PEDIATRIC BLOOD & CANCER

Female mice ultrasonically interact with males during courtship displays

(2015) Joshua P Neunuebel et al.   eLife

Mapk/Erk activation in an animal model of social deficits shows a possible link to autism

(2015) Alireza Faridar et al.   Molecular Autism

Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders

(2014) Dalila Pinto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Behavioral Profile in RASopathies

(2014) Paolo Alfieri et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Prevalence of Autism Spectrum Disorder symptoms in children with neurofibromatosis type 1

(2014) Ellen Plasschaert et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

γ-band abnormalities as markers of autism spectrum disorders

(2014) Donald C Rojas et al.   Biomarkers in Medicine

Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model

(2014) I. Filonova et al.   LEARNING & MEMORY

MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR

(2014) Longbo Zhang et al.   NEURON

Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism

(2014) Ronald R Seese et al.   NEUROPSYCHOPHARMACOLOGY

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

(2014) Christos G. Gkogkas et al.   Cell Reports

Autism traits in the RASopathies

(2013) Brigid Adviento et al.   JOURNAL OF MEDICAL GENETICS

A Target Cell-Specific Role for Presynaptic Fmr1 in Regulating Glutamate Release onto Neocortical Fast-Spiking Inhibitory Neurons

(2013) A. B. Patel et al.   JOURNAL OF NEUROSCIENCE

Autism

(2013) Meng-Chuan Lai et al.   LANCET

Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

(2013) Thomas A Lanz et al.   Molecular Autism

ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities

(2012) Yuan Wang et al.   CELL

Symptomatology of autism spectrum disorder in a population with neurofibromatosis type 1

(2012) KARIN S WALSH et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

(2012) Ruth Simon et al.   EMBO JOURNAL

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Disrupted ERK Signaling during Cortical Development Leads to Abnormal Progenitor Proliferation, Neuronal and Network Excitability and Behavior, Modeling Human Neuro-Cardio-Facial-Cutaneous and Related Syndromes

(2012) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Impaired inhibitory control of cortical synchronization in fragile X syndrome

(2011) Scott M. Paluszkiewicz et al.   JOURNAL OF NEUROPHYSIOLOGY

Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters

(2010) M. L. Scattoni et al.   GENES BRAIN AND BEHAVIOR

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Communication, interventions, and scientific advances in autism: A commentary

(2010) Danielle C. Llaneza et al.   PHYSIOLOGY & BEHAVIOR

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

(2010) Dan Ehninger et al.   TRENDS IN MOLECULAR MEDICINE

CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep

(2010) Hendrik W Steenland et al.   Molecular Brain

Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat

(2009) Aida Maddahi et al.   BMC NEUROSCIENCE

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

(2009) C. Iverson et al.   CANCER RESEARCH

Improved Measurement of Drug Exposure in the Brain Using Drug-Specific Correction for Residual Blood

(2009) Markus Fridén et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

(2009) Pat Levitt et al.   JOURNAL OF CLINICAL INVESTIGATION

MAP'ing CNS Development and Cognition: An ERKsome Process

(2009) Ivy S. Samuels et al.   NEURON

Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum

(2008) P. Arlotta et al.   JOURNAL OF NEUROSCIENCE