Prediction of drug cocktail effects when the number of measurements is limited

A simple gene set-based method accurately predicts the synergy of drug pairs

(2016) Yu-Ching Hsu et al.   BMC Systems Biology

Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

(2016) Samira Jaeger et al.   CANCER RESEARCH

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

(2016) Marc Hafner et al.   NATURE METHODS

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

(2016) Aleidy Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pairwise interactions and the battle against combinatorics in multidrug therapies

(2016) Kevin B. Wood   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of multidimensional drug dose responses based on measurements of drug pairs

(2016) Anat Zimmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform

(2016) Ali Zarrinpar et al.   Science Translational Medicine

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

(2015) Andrea Weiss et al.   ANGIOGENESIS

Unconventional screening approaches for antibiotic discovery

(2015) Maya A. Farha et al.   Annals of the New York Academy of Sciences

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model

(2015) Bhagwan Yadav et al.   Computational and Structural Biotechnology Journal

Synergistic and Antagonistic Drug Combinations Depend on Network Topology

(2014) Ning Yin et al.   PLoS One

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Uncovering Scaling Laws to Infer Multidrug Response of Resistant Microbes and Cancer Cells

(2014) Kevin B. Wood et al.   Cell Reports

Bayesian Active Learning for Drug Combinations

(2013) Mijung Park et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Rethinking the war on cancer

(2013) Douglas Hanahan   LANCET

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Genotype to Phenotype Mapping and the Fitness Landscape of the E. coli lac Promoter

(2013) Jakub Otwinowski et al.   PLoS One

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

(2013) T. Pemovska et al.   Cancer Discovery

CancerDR: Cancer Drug Resistance Database

(2013) Rahul Kumar et al.   Scientific Reports

A Network Inference Method for Large-Scale Unsupervised Identification of Novel Drug-Drug Interactions

(2013) Roger Guimerà et al.   PLoS Computational Biology

Nanoparticle-based combination therapy toward overcoming drug resistance in cancer

(2012) Che-Ming Jack Hu et al.   BIOCHEMICAL PHARMACOLOGY

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Mechanism-independent method for predicting response to multidrug combinations in bacteria

(2012) Kevin Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice

(2011) L. V. Sequist et al.   ANNALS OF ONCOLOGY

Systematic quantitative characterization of cellular responses induced by multiple signals

(2011) Ibrahim Al-Shyoukh et al.   BMC Systems Biology

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses

(2010) Naama Geva-Zatorsky et al.   CELL

Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions

(2009) Tobias Bollenbach et al.   CELL

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Search Algorithms as a Framework for the Optimization of Drug Combinations

(2008) Diego Calzolari et al.   PLoS Computational Biology