Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine

Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations

(2017) Maxmillian Mpina et al.   JOURNAL OF IMMUNOLOGY

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

(2017) Dmitri Kazmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

(2016) Hannes Uchtenhagen et al.   Nature Communications

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

(2015) Amy W. Chung et al.   CELL

Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data

(2015) Lin Lin et al.   CYTOMETRY PART A

Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I–III trials

(2015) Selidji T Agnandji et al.   Future Microbiology

Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains

(2015) Raul Herrera et al.   INFECTION AND IMMUNITY

Proteolytic Cleavage of thePlasmodium falciparumCircumsporozoite Protein Is a Target of Protective Antibodies

(2015) Diego A. Espinosa et al.   JOURNAL OF INFECTIOUS DISEASES

COMPASS identifies T-cell subsets correlated with clinical outcomes

(2015) Lin Lin et al.   NATURE BIOTECHNOLOGY

Ad35.CS.01 - RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

(2015) Christian F. Ockenhouse et al.   PLoS One

Plasmodium cellular effector mechanisms and the hepatic microenvironment

(2015) Ute Frevert et al.   Frontiers in Microbiology

Antigen-driven focal inflammatory death of malaria liver stages

(2015) Ganchimeg Bayarsaikhan et al.   Frontiers in Microbiology

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

IL-2 Producing Memory CD4+ T Lymphocytes Are Closely Associated with the Generation of IgG-Secreting Plasma Cells

(2014) N. H. R. Litjens et al.   JOURNAL OF IMMUNOLOGY

Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites

(2014) Hong Zheng et al.   MEDIATORS OF INFLAMMATION

The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors

(2014) William E. O’Gorman et al.   VACCINE

Interferon-Mediated Innate Immune Responses against Malaria Parasite Liver Stages

(2014) Jessica L. Miller et al.   Cell Reports

Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

(2014)   PLOS MEDICINE

APC licensing and CD4+T cell help in liver-stage malaria

(2014) Ian N. Crispe   Frontiers in Microbiology

CD8+T Cells Specific for a Malaria Cytoplasmic Antigen Form Clusters around Infected Hepatocytes and Are Protective at the Liver Stage of Infection

(2013) Kazumi Kimura et al.   INFECTION AND IMMUNITY

Identifying the Initiating Events of Anti-Listeria Responses Using Mice with Conditional Loss of IFN-  Receptor Subunit 1 (IFNGR1)

(2013) S. H. Lee et al.   JOURNAL OF IMMUNOLOGY

The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection

(2013) Michael T. White et al.   PLoS One

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages

(2013) I. A. Cockburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biological approaches to measure and understand vaccine immunity in humans

(2013) Shuzhao Li et al.   SEMINARS IN IMMUNOLOGY

Is CD69 an effective brake to control inflammatory diseases?

(2013) Roberto González-Amaro et al.   TRENDS IN MOLECULAR MEDICINE

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Strategy of lipid recognition by invariant natural killer T cells: ‘one for all and all for one’

(2012) Thierry Mallevaey et al.   IMMUNOLOGY

MHC Class II Tetramers

(2012) G. T. Nepom   JOURNAL OF IMMUNOLOGY

A Phase 1/2 Clinical Trial Evaluating Safety and Immunogenicity of a Varicella Zoster Glycoprotein E Subunit Vaccine Candidate in Young and Older Adults

(2012) Isabel Leroux-Roels et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccine applications of flow cytometry

(2012) Stephen C. De Rosa   METHODS

A Statistical Interaction between Circumsporozoite Protein-Specific T Cell and Antibody Responses and Risk of Clinical Malaria Episodes following Vaccination with RTS,S/AS01E

(2012) Francis M. Ndungu et al.   PLoS One

An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers

(2011) Eva Van Braeckel et al.   CLINICAL INFECTIOUS DISEASES

Targeting the diverse immunological functions expressed by hepatic NKT cells

(2011) Caroline C Duwaerts et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

(2011) Nathalie Garçon et al.   Expert Review of Vaccines

Induction of Strong HIV-1–Specific CD4+ T-Cell Responses Using an HIV-1 gp120/NefTat Vaccine Adjuvanted With AS02A in Antiretroviral-Treated HIV-1–Infected Individuals

(2011) Mathias Lichterfeld et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

(2011) Alida Coppi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety and efficacy of the RTS,S/AS01 E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

(2011) Kwaku Poku Asante et al.   LANCET INFECTIOUS DISEASES

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5–17 months in Kenya and Tanzania: a randomised controlled trial

(2011) Ally Olotu et al.   LANCET INFECTIOUS DISEASES

Inhibitory Effect of TNF-α on Malaria Pre-Erythrocytic Stage Development: Influence of Host Hepatocyte/Parasite Combinations

(2011) Nadya Depinay et al.   PLoS One

Induction of Plasmodium falciparum-Specific CD4+ T Cells and Memory B Cells in Gabonese Children Vaccinated with RTS,S/AS01E and RTS,S/AS02D

(2011) Selidji T. Agnandji et al.   PLoS One

T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

(2011) Daniel Ansong et al.   PLoS One

Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-α Producing Effector and Central Memory CD4+ T Cells

(2011) Joanne M. Lumsden et al.   PLoS One

Circumsporozoite-Specific T Cell Responses in Children Vaccinated with RTS,S/AS01E and Protection against P falciparum Clinical Malaria

(2011) Ally Olotu et al.   PLoS One

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Immunization with the RTS,S/AS malaria vaccine induces IFN-γ+CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge

(2011) Robert Schwenk et al.   VACCINE

Adenovirus particles that display the Plasmodium falciparum circumsporozoite protein NANP repeat induce sporozoite-neutralizing antibodies in mice

(2011) Christopher Palma et al.   VACCINE

Evaluation of the Safety and Immunogenicity of Two Antigen Concentrations of the Mtb72F/AS02A Candidate Tuberculosis Vaccine in Purified Protein Derivative-Negative Adults

(2010) I. Leroux-Roels et al.   Clinical and Vaccine Immunology

From the circumsporozoite protein to the RTS,S/AS candidate vaccine

(2010) Joe Cohen et al.   Human vaccines & immunotherapeutics

NK Cells as Effectors of Acquired Immune Responses: Effector CD4+ T Cell-Dependent Activation of NK Cells Following Vaccination

(2010) A. Horowitz et al.   JOURNAL OF IMMUNOLOGY

Primed Antigen-Specific CD4+ T Cells Are Required for NK Cell Activation In Vivo upon Leishmania major Infection

(2010) F. Bihl et al.   JOURNAL OF IMMUNOLOGY

Further Analysis of Correlates of Protection from a Phase 2a Trial of the Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults

(2010) Ally Ibrahim Olotu et al.   JOURNAL OF INFECTIOUS DISEASES

Expression of Genes Associated with Immunoproteasome Processing of Major Histocompatibility Complex Peptides Is Indicative of Protection with Adjuvanted RTS,S Malaria Vaccine

(2010) Maryanne T. Vahey et al.   JOURNAL OF INFECTIOUS DISEASES

Acquired Immunity to Malaria

(2009) D. L. Doolan et al.   CLINICAL MICROBIOLOGY REVIEWS

The relationship between human effector and memory T cells measured byex vivoand cultured ELISPOT following recent and distal priming

(2009) Stephen M. Todryk et al.   IMMUNOLOGY

Plasmodium falciparum-Specific Cellular Immune Responses after Immunization with the RTS,S/AS02D Candidate Malaria Vaccine in Infants Living in an Area of High Endemicity in Mozambique

(2009) A. Barbosa et al.   INFECTION AND IMMUNITY

Structure of thePlasmodium falciparumCircumsporozoite Protein, a Leading Malaria Vaccine Candidate

(2009) Matthew L. Plassmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long‐Term Safety and Efficacy of the RTS,S/AS02A Malaria Vaccine in Mozambican Children

(2009) Jahit Sacarlal et al.   JOURNAL OF INFECTIOUS DISEASES

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data

(2009) Vasee S Moorthy et al.   MALARIA JOURNAL

How might infant and paediatric immune responses influence malaria vaccine efficacy?

(2009) A. M. MOORMANN   PARASITE IMMUNOLOGY

The development of the RTS,S malaria vaccine candidate: challenges and lessons

(2009) W. R. BALLOU   PARASITE IMMUNOLOGY

Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area

(2009) Mark E. Polhemus et al.   PLoS One

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

(2009) James F. Cummings et al.   VACCINE

Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age

(2008) Philip Bejon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

(2008) Kent E. Kester et al.   VACCINE