Article
Oncology
Nadine Landolina, Francesca Romana Mariotti, Tiziano Ingegnere, Claudia Alicata, Biancamaria Ricci, Andrea Pelosi, Irene Veneziani, Bruno Giuseppe Azzarone, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Summary: This study aimed to investigate the role of IL-1R8 in human NK cells and optimize its silencing conditions. The results showed that silencing IL-1R8 can enhance the activity and anti-tumor response of NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Adam Nelson, Simon Gebremeskel, Brian D. Lichty, Brent Johnston
Summary: The combination of NKT cell activation therapy, oncolytic virotherapy with VSV-IL-15, and PD-1 blockade has been shown to enhance tumor control in pancreatic cancer, providing a promising treatment strategy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Giulia Marelli, Louisa S. Chard Dunmall, Ming Yuan, Carmela Di Gioia, Jinxin Miao, Zhenguo Cheng, Zhongxian Zhang, Peng Liu, Jahangir Ahmed, Rathi Gangeswaran, Nicholas Lemoine, Yaohe Wang
Summary: The modified VVL-21 virus showed antitumor efficacy in models of pancreatic cancer after systemic delivery, increasing the number of effector CD8+ T cells and sensitizing tumors to immune checkpoint inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Xue Xiao, Cui-Liu Hou, Yun-Long Zhang, Hui Yang, Xiao-Xiao Wang, Hong-Xia Wang
Summary: This study identified the important role of CD1d-dependent NKT cells in hypertension and vascular injury, suggesting that NKT cell activation could be a promising therapeutic target for hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Immunology
Michael S. Lee, Tonya J. Webb
Summary: Cancer immunotherapy aims to harness the immune system's power to fight tumors while avoiding the side effects of traditional chemotherapy. iNKT cells, a type of innate immune cell, have gained recognition for their potential in cancer immunotherapy. They recognize lipid antigens presented on the MHC I-like molecule CD1d, representing a unique feature of tumor cells that can be exploited by iNKT cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Young Min Chung, Pragya P. Khan, Hong Wang, Wen-Bin Tsai, Yanli Qiao, Bo Yu, James W. Larrick, Mickey C-T Hu
Summary: The study explored the efficacy of low-dose antineoplastic agents SN-38 or metformin in sensitizing unresponsive tumors to respond to immune-checkpoint blockade therapy. Results showed these agents could suppress c-Myc and STAT3 through FOXO3 activation, thus boosting antitumor immunity by promoting NK and CD8+ T cell infiltration in the tumor microenvironment. These findings offer potential insights for improving patient responses to immunotherapy for tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Li-Rui Chen, Hui-Yang, Lu-Liu, Xiao-Xiao Wang, Xiao-Man Zhang, Hong-Xia Wang
Summary: Myocardial edema caused by endothelial dysfunction is a key factor in sepsis-induced cardiomyopathy. This study investigates the role of CD1d-dependent natural killer T cells in protecting the heart and explores the underlying mechanism in a mouse model. The results show that CD1d-deficient mice had worse outcomes, including higher mortality, cardiac dysfunction, myocardial injury, endothelial apoptosis, microvascular damage, increased microvascular permeability, and cardiac edema. CD1d deficiency also led to increased accumulation of T lymphocytes and IL-6 production in the myocardium. Blocking IL-6 improved cardiac dysfunction, myocardial injury, and edema in CD1d-deficient mice. Activation of CD1d-dependent NKT cells may be a potential treatment strategy for sepsis-induced cardiomyopathy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Qibin Lin, Tong Wang, Xiaoshu Zuo, Haiyang Ni, Jieying Zhong, Liying Zhan, Hong Cheng, Yi Huang, Xuhong Ding, Hongying Yu, Hanxiang Nie
Summary: This study found that anti-CD1d treatment can suppress Th2 cell responses by inhibiting the immunogenic maturation of LDCs dependent on lung iNKT cells in asthmatic mice. The downregulation of CD40L expression on lung iNKT cells in asthmatic mice may be partially related to this mechanism.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Carla Kirschbaum, Kim Greis, Eike Mucha, Lisa Kain, Shenglou Deng, Andreas Zappe, Sandy Gewinner, Wieland Schoellkopf, Gert von Helden, Gerard Meijer, Paul B. Savage, Mateusz Marianski, Luc Teyton, Kevin Pagel
Summary: This study investigates isomerism in immunologically relevant glycolipids using cryogenic gas-phase infrared spectroscopy, and shows that their structural features can be accurately resolved based on a narrow spectral fingerprint region.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Yongwei Qin, Qinglan Wang, Jiahai Shi
Summary: The down-regulated expression of immune-activating receptors and enhanced expression of immune-inhibitory receptors play a role in chronic infectious diseases and cancer. However, the impact of Mycobacterium tuberculosis infection on the expression of immune checkpoint molecules on natural killer (NK) cells and their functions has been poorly studied. Understanding the function of NK cells during Mtb infection is crucial for a comprehensive understanding of the immune mechanism and evaluation of immunotherapies for treating tuberculosis.
MICROBIOLOGICAL RESEARCH
(2023)
Review
Oncology
Fengyun Zhong, Yilin Lin, Xiangxiang Jing, Yingjiang Ye, Shan Wang, Zhanlong Shen
Summary: The immune microenvironment and immunotherapies of colorectal cancer (CRC) have attracted extensive attention, with a focus on T cells. However, innate immune cells such as NK cells, NKT cells, and gamma 8T cells also play important roles in CRC. The anti-tumorigenic and pro-tumorigenic mechanisms of these cells are still under investigation, and immunotherapies utilizing these cells have shown efficacy in animal models and are being explored in clinical trials.
Review
Oncology
Faroogh Marofi, Alaa S. Al-Awad, Heshu Sulaiman Rahman, Alexander Markov, Walid Kamal Abdelbasset, Yulianna Ivanovna Enina, Mahnaz Mahmoodi, Ali Hassanzadeh, Mahboubeh Yazdanifar, Max Stanley Chartrand, Mostafa Jarahian
Summary: CAR-NK cells, as an emerging cancer treatment, have various advantages in cancer immunotherapy, including better safety and adaptability, and the ability to improve attack on tumors and eliminate resistance. By targeting different antigens, CAR-NK cells are expected to achieve more effective anti-tumor responses.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell & Tissue Engineering
Batol Abbasi, Karim Shamsasenjan, Majid Ahmadi, Seyedeh Ameneh Beheshti, Mahshid Saleh
Summary: This article discusses the interaction and signaling pathway between NK cells and MSCs, as well as their importance in clinical applications.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hsing-Chun Kuo, Yen-Wenn Liu, Chi-Chin Lum, Kai-Di Hsu, Shin-Ping Lin, Chang-Wei Hsieh, Hui-Wen Lin, Tze-Ying Lu, Kuan-Chen Cheng
Summary: The study demonstrates that GF-EPS effectively suppresses LLC1 tumor growth in both preventive and therapeutic models by increasing the proportion of natural killer cells in the spleen and activating gene expression of various cytokines, indicating immunomodulatory effects on tumor inhibition in tumor-bearing mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Khder H. Rasul, Alamdar Hussain, Hazel Reilly, Maria Karvouni, Carin I. M. Dahlberg, Mustafa S. Al-Attar, Arnika K. Wagner, Evren Alici, Dara K. Mohammad
Summary: This study investigates the cellular processing of the TCR complex in NK cells. The findings suggest that the absence of CD3 subunits prevents surface expression of the TCR complex in NK cells. Additionally, TCR expression on the surface of NK cells gradually increases after transduction. The TCR complex in NK92 cells is shown to be functional.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Immunology
Nichole K. Escalante, Paul Lemire, Mayra Cruz Tleugabulova, David Prescott, Arthur Mortha, Catherine J. Streutker, Stephen E. Girardin, Dana J. Philpott, Thierry Mallevaey
JOURNAL OF EXPERIMENTAL MEDICINE
(2016)
Article
Immunology
Thirumahal Selvanantham, Qiaochu Lin, Cynthia Xinyi Guo, Anuradha Surendra, Stephanie Fieve, Nichole K. Escalante, David S. Guttman, Catherine J. Streuther, Susan J. Robertson, Dana J. Philpott, Thierry Mallevaey
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Mayra Cruz Tleugabulova, Nichole K. Escalante, Shenglou Deng, Stephanie Fieve, June Ereno-Orbea, Paul B. Savage, Jean-Philippe Julien, Thierry Mallevaey
JOURNAL OF IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
Jeeyoon Jennifer Ahn, Thirumahal Selvanantham, Monan Angela Zhang, Thierry Mallevaey, Shannon E. Dunn
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Immunology
Yuriy Baglaenko, Mayra Cruz Tleugabulova, Eric Gracey, Nafiseh Talaei, Kieran Patricia Manion, Nan-Hua Chang, Dario Michael Ferri, Thierry Mallevaey, Joan E. Wither
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Mayra Cruz Tleugabulova, Meng Zhao, Irene Lau, Meggie Kuypers, Clarissa Wirianto, Juan Mauricio Umana, Qiaochu Lin, Mitchell Kronenberg, Thierry Mallevaey
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Yan Lu, Ming-Chao Zhong, Jin Qian, Virginie Calderon, Mayra Cruz Tleugabulova, Thierry Mallevaey, Andre Veillette
Article
Biochemistry & Molecular Biology
Christophe Paget, Shenglou Deng, Daphnee Soulard, David A. Priestman, Silvia Speca, Johanna von Gerichten, Anneliese O. Speak, Ashish Saroha, Yael Pewzner-Jung, Anthony H. Futerman, Thierry Mallevaey, Christelle Faveeuw, Xiaobo Gu, Frances M. Platt, Roger Sandhoff, Francois Trottein
Article
Biochemistry & Molecular Biology
Ge Ying, Jing Wang, Thierry Mallevaey, Serge Van Calenbergh, Dirk M. Zajonc
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Immunology
Qiaochu Lin, Meggie Kuypers, Dana J. Philpott, Thierry Mallevaey
MUCOSAL IMMUNOLOGY
(2020)
Article
Cell Biology
Thomas Baranek, Kevin Lebrigand, Carolina de Amat Herbozo, Loic Gonzalez, Gemma Bogard, Celine Dietrich, Virginie Magnone, Chloe Boisseau, Youenn Jouan, Francois Trottein, Mustapha Si-Tahar, Maria Leite-de-Moraes, Thierry Mallevaey, Christophe Paget
Article
Immunology
Meggie Kuypers, Tijana Despot, Thierry Mallevaey
Summary: The microbiota plays a significant role in influencing host physiological functions. This review discusses methods used in studying host-microbiota interactions that control immune fitness and disease susceptibility, with a particular focus on the recent incorporation of "dirty mice" into the immunologist's toolkit.
MICROBES AND INFECTION
(2021)
Review
Oncology
Emilie Barsac, Carolina de Amat Herbozo, Loic Gonzalez, Thomas Baranek, Thierry Mallevaey, Christophe Paget
Summary: This review highlights the emerging role of unconventional T cells in tumor immunity, focusing on their protumoral functions and the factors in the tumor microenvironment shaping and controlling these deleterious properties. Unconventional T cells like gamma delta T cells, natural killer T (NKT) cells, and mucosal-associated invariant T (MAIT) cells span the innate-adaptive continuum and possess unique abilities to rapidly react to nonpeptide antigens. The potential therapeutic implications of targeting these unconventional T cell subsets in solid cancers are discussed, along with the need for further feasibility studies in this area.
Review
Immunology
Thomas Baranek, Carolina de Amat Herbozo, Thierry Mallevaey, Christophe Paget
Summary: Invariant natural killer T (iNKT) cells are important biomarkers and targets for immunotherapy. Recent studies have revealed the heterogeneity of iNKT cells and challenged our understanding of their development and differentiation. A new model is proposed to explain the classification and differentiation of iNKT cells.
TRENDS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K. Copeland, Donny Chan, Susan J. Robertson, Jean Kontogiannis, David S. Guttman, E. Kate Banks, Dana J. Philpott, Thierry Mallevaey
Summary: This study demonstrates that iNKT cells have minimal influence on regulating commensal bacteria in the gut at steady state.