Neuroimaging genomics in psychiatry—a translational approach

Association of stress hormone system, epigenetics and imaging

(2017) T. Frodl et al.   EUROPEAN PSYCHIATRY

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

(2017) S Kelly et al.   MOLECULAR PSYCHIATRY

The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders

(2017) H Chang et al.   MOLECULAR PSYCHIATRY

Early brain development in infants at high risk for autism spectrum disorder

(2017) Heather Cody Hazlett et al.   NATURE

Novel genetic loci associated with hippocampal volume

(2017) Derrek P. Hibar et al.   Nature Communications

Post-mortem molecular profiling of three psychiatric disorders

(2017) Ryne C. Ramaker et al.   Genome Medicine

Finding the Elusive Psychiatric “Lesion” With 21st-Century Neuroanatomy: A Note of Caution

(2016) Daniel R. Weinberger et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effect of the interaction between childhood abuse and rs1360780 of theFKBP5gene on gray matter volume in a general population sample

(2016) Hans Jörgen Grabe et al.   HUMAN BRAIN MAPPING

Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia

(2016) P H Lee et al.   MOLECULAR PSYCHIATRY

Subcortical volumetric abnormalities in bipolar disorder

(2016) D P Hibar et al.   MOLECULAR PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

(2016) Barbara Franke et al.   NATURE NEUROSCIENCE

Novel genetic loci underlying human intracranial volume identified through genome-wide association

(2016) Hieab H H Adams et al.   NATURE NEUROSCIENCE

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects

(2016) Thelma Beatriz González-Castro et al.   NEUROMOLECULAR MEDICINE

Gene transcription profiles associated with inter-modular hubs and connection distance in human functional magnetic resonance imaging networks

(2016) Petra E. Vértes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A transcriptional signature of hub connectivity in the mouse connectome

(2016) Ben D. Fulcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder

(2016) J. Paul Hamilton et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression

(2016) Y. A. de Vries et al.   PSYCHOLOGICAL MEDICINE

Heritability of the shape of subcortical brain structures in the general population

(2016) Gennady V. Roshchupkin et al.   Nature Communications

Multidimensional heritability analysis of neuroanatomical shape

(2016) Tian Ge et al.   Nature Communications

The International Human Epigenome Consortium Data Portal

(2016) David Bujold et al.   Cell Systems

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

(2015) L Schmaal et al.   MOLECULAR PSYCHIATRY

Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

(2015) T G M van Erp et al.   MOLECULAR PSYCHIATRY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Common genetic variants influence human subcortical brain structures

(2015) Derrek P. Hibar et al.   NATURE

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

The connectomics of brain disorders

(2015) Alex Fornito et al.   NATURE REVIEWS NEUROSCIENCE

Genome-wide interaction analysis reveals replicated epistatic effects on brain structure

(2015) Derrek P. Hibar et al.   NEUROBIOLOGY OF AGING

Head motion during MRI acquisition reduces gray matter volume and thickness estimates

(2015) Martin Reuter et al.   NEUROIMAGE

Correspondence between Resting-State Activity and Brain Gene Expression

(2015) Guang-Zhong Wang et al.   NEURON

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

(2015) Janine Arloth et al.   NEURON

What Twin Studies Tell Us About the Heritability of Brain Development, Morphology, and Function: A Review

(2015) Arija G. Jansen et al.   NEUROPSYCHOLOGY REVIEW

Genetic Moderation of Stress Effects on Corticolimbic Circuitry

(2015) Ryan Bogdan et al.   NEUROPSYCHOPHARMACOLOGY

Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression

(2015) Leonardo Tozzi et al.   NEUROPSYCHOPHARMACOLOGY

Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research

(2015) Esther Walton et al.   SCHIZOPHRENIA BULLETIN

Correlated gene expression supports synchronous activity in brain networks

(2015) J. Richiardi et al.   SCIENCE

Can we observe epigenetic effects on human brain function?

(2015) Yuliya S. Nikolova et al.   TRENDS IN COGNITIVE SCIENCES

Large-scale genomics unveil polygenic architecture of human cortical surface area

(2015) Chi-Hua Chen et al.   Nature Communications

Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures

(2015) Avram J. Holmes et al.   Scientific Data

Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed

(2015) Shareefa Dalvie et al.   EBioMedicine

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

(2014) Joseph K. Pickrell   AMERICAN JOURNAL OF HUMAN GENETICS

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

(2014) A M Maillard et al.   MOLECULAR PSYCHIATRY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Real-Time fMRI Neurofeedback Training of Amygdala Activity in Patients with Major Depressive Disorder

(2014) Kymberly D. Young et al.   PLoS One

Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding

(2014) B H Schott et al.   Translational Psychiatry

Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume

(2013) Angela Carballedo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

DSM-5 Field Trials in the United States and Canada, Part II: Test-Retest Reliability of Selected Categorical Diagnoses

(2013) Darrel A. Regier et al.   AMERICAN JOURNAL OF PSYCHIATRY

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

(2013) Bruce N Cuthbert et al.   BMC Medicine

Personalized medicine in psychiatry: problems and promises

(2013) Uzoezi Ozomaro et al.   BMC Medicine

Multivariate pattern analysis of DTI reveals differential white matter in individuals with obsessive-compulsive disorder

(2013) Fei Li et al.   HUMAN BRAIN MAPPING

Association of rs1006737 inCACNA1Cwith alterations in prefrontal activation and fronto-hippocampal connectivity

(2013) Frieder M. Paulus et al.   HUMAN BRAIN MAPPING

Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans

(2013) F Papaleo et al.   MOLECULAR PSYCHIATRY

Opportunities and limitations of intrinsic functional connectivity MRI

(2013) Randy L Buckner et al.   NATURE NEUROSCIENCE

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Guided exploration of genomic risk for gray matter abnormalities in schizophrenia using parallel independent component analysis with reference

(2013) Jiayu Chen et al.   NEUROIMAGE

Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group

(2013) Neda Jahanshad et al.   NEUROIMAGE

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

The advantages and limitations of trait analysis with GWAS: a review

(2013) Arthur Korte et al.   Plant Methods

Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

(2013) N. Jahanshad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacogenetics in major depression: A comprehensive meta-analysis

(2013) Tomihisa Niitsu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses

(2013) Monica Aas et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

Gene Network Effects on Brain Microstructure and Intellectual Performance Identified in 472 Twins

(2012) M.-C. Chiang et al.   JOURNAL OF NEUROSCIENCE

Individual Differences in Amygdala-Medial Prefrontal Anatomy Link Negative Affect, Impaired Social Functioning, and Polygenic Depression Risk

(2012) A. J. Holmes et al.   JOURNAL OF NEUROSCIENCE

Common variants at 12q14 and 12q24 are associated with hippocampal volume

(2012) et al.   NATURE GENETICS

Identification of common variants associated with human hippocampal and intracranial volumes

(2012) Jason L Stein et al.   NATURE GENETICS

Significant correlation between a set of genetic polymorphisms and a functional brain network revealed by feature selection and sparse Partial Least Squares

(2012) Édith Le Floch et al.   NEUROIMAGE

Increasing power for voxel-wise genome-wide association studies: The random field theory, least square kernel machines and fast permutation procedures

(2012) Tian Ge et al.   NEUROIMAGE

Multifaceted genomic risk for brain function in schizophrenia

(2012) Jiayu Chen et al.   NEUROIMAGE

Investigating Structural Brain Changes of Dehydration Using Voxel-Based Morphometry

(2012) Daniel-Paolo Streitbürger et al.   PLoS One

A Pilot Study on Collective Effects of 22q13.31 Deletions on Gray Matter Concentration in Schizophrenia

(2012) Jingyu Liu et al.   PLoS One

Temporally-independent functional modes of spontaneous brain activity

(2012) S. M. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse

(2012) O. E. Onwuameze et al.   PSYCHOLOGICAL MEDICINE

Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia

(2012) E. J. Rose et al.   SCHIZOPHRENIA BULLETIN

Hierarchical Genetic Organization of Human Cortical Surface Area

(2012) C.-H. Chen et al.   SCIENCE

The Allen Human Brain Atlas

(2012) Elaine H. Shen et al.   TRENDS IN NEUROSCIENCES

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

(2012) Matthew N Davies et al.   GENOME BIOLOGY

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

(2011) Laramie E. Duncan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Intermediate phenotypes in psychiatric disorders

(2011) Roberta Rasetti et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy

(2011) Stefano Porcelli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Stress-Related Methylation of the Catechol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity

(2011) G. Ursini et al.   JOURNAL OF NEUROSCIENCE

Therapygenetics: the 5HTTLPR and response to psychological therapy

(2011) T C Eley et al.   MOLECULAR PSYCHIATRY

BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects

(2011) L Gerritsen et al.   MOLECULAR PSYCHIATRY

Genetic Influences on Cortical Regionalization in the Human Brain

(2011) Chi-Hua Chen et al.   NEURON

Multilocus Genetic Profile for Dopamine Signaling Predicts Ventral Striatum Reactivity

(2011) Yuliya S Nikolova et al.   NEUROPSYCHOPHARMACOLOGY

The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

(2011) Qiumei Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition

(2011) Gisela Sugranyes et al.   PLoS One

Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia

(2011) Beng-Choon Ho et al.   SCHIZOPHRENIA RESEARCH

Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa

(2011) Mahsa Shokouhi et al.   BMC MEDICAL IMAGING

Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies

(2010) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

(2010) Avshalom Caspi et al.   AMERICAN JOURNAL OF PSYCHIATRY

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Biological Validation of Increased Schizophrenia Risk With NRG1, ERBB4, and AKT1 Epistasis via Functional Neuroimaging in Healthy Controls

(2010) Kristin K. Nicodemus et al.   ARCHIVES OF GENERAL PSYCHIATRY

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

(2010) Kristin L. Bigos et al.   ARCHIVES OF GENERAL PSYCHIATRY

A Hybrid Machine Learning Method for Fusing fMRI and Genetic Data: Combining both Improves Classification of Schizophrenia

(2010) Honghui Yang et al.   Frontiers in Human Neuroscience

Mapping reliability in multicenter MRI: Voxel-based morphometry and cortical thickness

(2010) Hugo G. Schnack et al.   HUMAN BRAIN MAPPING

Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging

(2010) Kristin K. Nicodemus et al.   HUMAN GENETICS

The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology

(2010) G Schumann et al.   MOLECULAR PSYCHIATRY

CACNA1C (rs1006737) is associated with schizophrenia

(2010) M Nyegaard et al.   MOLECULAR PSYCHIATRY

Imaging genetics—days of future past

(2010) Kristin L. Bigos et al.   NEUROIMAGE

Discovering genetic associations with high-dimensional neuroimaging phenotypes: A sparse reduced-rank regression approach

(2010) Maria Vounou et al.   NEUROIMAGE

A web-based brain atlas of the vervet monkey, Chlorocebus aethiops

(2010) Roger P. Woods et al.   NEUROIMAGE

Genetics of white matter development: A DTI study of 705 twins and their siblings aged 12 to 29

(2010) Ming-Chang Chiang et al.   NEUROIMAGE

Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project

(2010) R Keers et al.   PHARMACOGENOMICS JOURNAL

Genetic control over the resting brain

(2010) D. C. Glahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stuck in a rut: rethinking depression and its treatment

(2010) Paul E. Holtzheimer et al.   TRENDS IN NEUROSCIENCES

Genetic Vulnerability to Affective Psychopathology in Childhood: A Combined Voxel-Based Morphometry and Functional Magnetic Resonance Imaging Study

(2009) Andrea Mechelli et al.   BIOLOGICAL PSYCHIATRY

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

(2009) Bruce M. Psaty et al.   Circulation-Cardiovascular Genetics

Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk

(2009) David M. Evans et al.   HUMAN MOLECULAR GENETICS

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety

(2009) J M Gatt et al.   MOLECULAR PSYCHIATRY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths

(2009) Jorge Jovicich et al.   NEUROIMAGE

Neural Mechanisms of a Genome-Wide Supported Psychosis Variant

(2009) C. Esslinger et al.   SCIENCE

Medication Effects in Neuroimaging Studies of Bipolar Disorder

(2008) Mary L. Phillips et al.   AMERICAN JOURNAL OF PSYCHIATRY

Interaction between SERTPR and stressful life events on response to antidepressant treatment

(2008) Laura Mandelli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Genome-wide significance for dense SNP and resequencing data

(2008) Clive J. Hoggart et al.   GENETIC EPIDEMIOLOGY

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

(2008) S G Potkin et al.   MOLECULAR PSYCHIATRY

Whole-genome association study of bipolar disorder

(2008) P Sklar et al.   MOLECULAR PSYCHIATRY

Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression

(2008) L Pezawas et al.   MOLECULAR PSYCHIATRY

What we can do and what we cannot do with fMRI

(2008) Nikos K. Logothetis   NATURE

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

(2008) Manuel A R Ferreira et al.   NATURE GENETICS

False positives in imaging genetics

(2008) Andreas Meyer-Lindenberg et al.   NEUROIMAGE

Impact of interacting functional variants in COMT on regional gray matter volume in human brain

(2008) Robyn Honea et al.   NEUROIMAGE

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

(2008) William G. Hill et al.   PLoS Genetics

Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA

(2007) Jingyu Liu et al.   HUMAN BRAIN MAPPING

Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent

(2007) Daniel J. Simmonds et al.   NEUROPSYCHOLOGIA