HMGB1 is a promising therapeutic target for acute liver failure

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

(2016) Elena Arriazu et al.   GUT

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of fibrosis in acute liver failure

(2015) Yingli He et al.   LIVER INTERNATIONAL

Acute atorvastatin is hepatoprotective against ischaemia-reperfusion injury in mice by modulating eNOS and microparticle formation

(2015) Hussam Ajamieh et al.   LIVER INTERNATIONAL

Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure

(2015) Giuseppina Basta et al.   LIVER TRANSPLANTATION

Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injuryviaTLR2/TLR4-triggered signaling pathways

(2015) Han-Fei Huang   WORLD JOURNAL OF GASTROENTEROLOGY

Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice

(2014) Changchun Cai et al.   HEPATOLOGY

High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD)

(2014) Xiaodong Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure

(2014) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

The Association of HMGB1 Expression with Clinicopathological Significance and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis and Literature Review

(2014) Lu Zhang et al.   PLoS One

TIFA upregulation after hypoxia–reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release

(2013) Ning Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure

(2013) Li-Kun Wang et al.   Hepatobiliary & Pancreatic Diseases International

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high-mobility group box 1 in cellular protection

(2013) Hai Huang et al.   HEPATOLOGY

Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats

(2013) Xun Li et al.   INFLAMMATION RESEARCH

Lessons from look-back in acute liver failure? A single centre experience of 3300 patients

(2013) William Bernal et al.   JOURNAL OF HEPATOLOGY

Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy

(2013) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Ammonia clearance with haemofiltration in adults with liver disease

(2013) Andrew J. Slack et al.   LIVER INTERNATIONAL

High levels of circulating HMGB1 as a biomarker of acute liver failure in patients with viral hepatitis E

(2013) Manasi Majumdar et al.   LIVER INTERNATIONAL

Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy

(2013) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase

(2013) H Fang et al.   Cell Death & Disease

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines

(2012) Jianjun Li et al.   BRAIN RESEARCH

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Liver transplantation for acute liver failure in Europe: Outcomes over 20years from the ELTR database

(2012) Giacomo Germani et al.   JOURNAL OF HEPATOLOGY

Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin

(2012) Almudena Laliena et al.   JOURNAL OF PINEAL RESEARCH

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Hepatitis E

(2012) Jay H. Hoofnagle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway

(2011) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells

(2011) Wen-Song Ge   WORLD JOURNAL OF GASTROENTEROLOGY

Protective Role of Heme Oxygenase-1 Against Liver Damage Caused by Hepatic Ischemia and Reperfusion in Rats

(2010) Nari Yun et al.   ANTIOXIDANTS & REDOX SIGNALING

Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia–reperfusion injury in rats*

(2010) Tetsu Yamamoto et al.   CRITICAL CARE MEDICINE

Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation

(2010) Alexander Dechêne et al.   HEPATOLOGY

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effect of High-Mobility Group Box 1 Blockade on Acute Liver Failure in Rats

(2010) Kiminori Takano et al.   SHOCK

PROTECTIVE EFFECTS OF HYDROGEN GAS ON MURINE POLYMICROBIAL SEPSIS VIA REDUCING OXIDATIVE STRESS AND HMGB1 RELEASE

(2010) Keliang Xie et al.   SHOCK

Quercetin Prevents LPS-Induced High-Mobility Group Box 1 Release and Proinflammatory Function

(2009) Daolin Tang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia

(2009) Masaru Nagato et al.   CRITICAL CARE MEDICINE

Predictors of bacteraemia and mortality in patients with acute liver failure

(2009) Constantine J. Karvellas et al.   INTENSIVE CARE MEDICINE

Alcoholic Hepatitis

(2009) Michael R. Lucey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

(2008) Takashi Ito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY