Article
Medicine, General & Internal
Supriya Ravichandran, Surender Khurana
Summary: A serodiagnostic test has been developed to differentiate between individuals with EBOV infection-induced antibodies and those with EBOV vaccine-induced antibodies. This test can accurately detect Ebola virus infections and could be implemented as a robust diagnostic tool for epidemiology and surveillance during and after outbreaks, especially in countries with mass Ebola vaccinations.
Article
Biochemistry & Molecular Biology
Leonardo Cassari, Angela Pavan, Giulia Zoia, Monica Chinellato, Elena Zeni, Alessandro Grinzato, Sylvia Rothenberger, Laura Cendron, Monica Dettin, Antonella Pasquato
Summary: The SARS-CoV-2 virus displays unique characteristics and has a high ability to spread among humans. The virus relies on Furin for its invasion and replication, and though there are mutations in the amino acid sequence, the dependence on Furin remains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Anitha D. D. Jayaprakash, Adam J. J. Ronk, Abhishek N. N. Prasad, Michael F. F. Covington, Kathryn R. R. Stein, Toni M. M. Schwarz, Saboor Hekmaty, Karla A. A. Fenton, Thomas W. W. Geisbert, Christopher F. F. Basler, Alexander Bukreyev, Ravi Sachidanandam
Summary: Filoviruses cause severe diseases in humans and nonhuman primates but have subclinical effects in bats. By infecting Egyptian rousette bats with Marburg and Ebola viruses, researchers identified various immune responses and pathways involved in bat resistance to these viruses, providing insights for the development of new strategies to treat and mitigate the diseases caused by these viruses in humans.
Article
Microbiology
Nivea Pereira de Sa, Kalani Jayanetti, Dominick Rendina, Timothy Clement, Veronica Soares Brauer, Caroline Mota Fernandes, Iwao Ojima, Michael V. Airola, Maurizio Del Poeta
Summary: Invasive fungal infections are a leading cause of death in immunocompromised patients. We studied the fungus-specific enzyme SglA as a therapeutic target and identified selective inhibitors that delay filamentation in the pathogenic fungus and increase survival in a murine model of pulmonary aspergillosis.
Article
Medicine, General & Internal
Karima Al-Akioui Sanz, Carlos Echecopar Parente, Cristina Ferreras, Marta Menendez Ribes, Alfonso Navarro, Carmen Mestre, Laura Clares, Jose Luis Vicario, Antonio Balas, Raquel De Paz, Eduardo Lopez Granados, Elena Sanchez Zapardiel, Carlos Jimenez, Maria Lopez-Oliva, Esther Ramos, Francisco Hernandez-Oliveros, Antonio Perez-Martinez
Summary: Immunocompromised patients are susceptible to high-risk opportunistic infections and malignant diseases. Transfer of pathogen-specific memory T-cells has shown effectiveness in treating infections, but regulatory issues, high cost, and absence of public cell banks limit its use. CD45RA(-) cells containing memory T-cells offer a cheaper and safer alternative. Preliminary data from six patients showed that infusions of CD45RA(-) cells led to pathogen clearance, symptom resolution, and increased lymphocyte count.
FRONTIERS IN MEDICINE
(2023)
Article
Virology
Marcel Bokelmann, Uwe Vogel, Franka Debeljak, Ariane Duex, Silke Riesle-Sbarbaro, Angelika Lander, Annette Wahlbrink, Nicole Kromarek, Stuart Neil, Emmanuel Couacy-Hymann, Joseph Prescott, Andreas Kurth
Summary: Recent studies suggest that the Angolan free-tailed bat may be a possible reservoir for Ebola virus, with bat cells showing high tolerance and the virus's ability to persist without mutation for up to 150 days. This provides further evidence for the role of this bat species as a likely reservoir for ebolaviruses.
Review
Virology
Toufik Abdul-Rahman, Lukman Lawal, Emily Meale, Oyinbolaji A. Ajetunmobi, Soyemi Toluwalashe, Uthman Hassan Alao, Shankhaneel Ghosh, Neil Garg, Abdullahi Tunde Aborode, Andrew Awuah Wireko, Aashna Mehta, Kateryna Sikora
Summary: The Ebola virus has caused multiple outbreaks in Africa with high fatality rates. Social factors such as human mobility, behavior, and cultural norms contribute to the transmission risk. However, challenges including lagging vaccine production pose a risk of another outbreak.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Medicine, Research & Experimental
Laura Marongiu, Mihai Valache, Fabio A. Facchini, Francesca Granucci
Summary: Dendritic cells play a crucial role in antiviral immunity by sensing viral pathogens and coordinating immune responses. Different subsets of DCs have complementary functions during viral infections, with a particular focus on their interaction with SARS-CoV-2. Although DC-mediated antiviral responses often lead to the production of proinflammatory cytokines and activation of adaptive immunity, the migratory properties of DCs can also contribute to further viral dissemination.
Article
Immunology
Axel T. Lehrer, Eleanore Chuang, Madhuri Namekar, Caitlin A. Williams, Teri Ann S. Wong, Michael M. Lieberman, Alex Granados, John Misamore, Jake Yalley-Ogunro, Hanne Andersen, Joan B. Geisbert, Krystle N. Agans, Robert W. Cross, Thomas W. Geisbert
Summary: The recombinant subunit vaccine platform shows potential in preventing Ebola, Marburg, and Sudan Virus Disease, with candidate vaccines eliciting potent immune responses in animal studies and providing effective protection against lethal virus infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Elizabeth J. Price, Alan N. Baer
Summary: Sjögren's Syndrome is a chronic autoimmune disease with no known cure, characterized by dryness of the eyes and mouth along with systemic manifestations. Treatment aims to empower patients in managing their condition, conserving secretions, preventing damage, and suppressing systemic disease activity.
Review
Chemistry, Analytical
Rostislav Bukasov, Dina Dossym, Olena Filchakova
Summary: The review focuses on RNA-based virus detection methods, including the detection of various viruses and human antibodies as well as the accuracy and specificity of different detection methods. The article also covers the research results of various detection methods and discusses the detection limits of each study.
ANALYTICAL METHODS
(2021)
Review
Biochemistry & Molecular Biology
Stefanie Maria Kremsreiter, Ann-Sophie Helene Kroell, Katharina Weinberger, Heike Boehm
Summary: Glycan-lectin interactions play crucial roles in cancer progression, metastasis, chemoresistance, viral entry, release, and immune evasion. Understanding these interactions may lead to new therapeutic strategies in various pathological contexts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Economics
Darin Christensen, Oeindrila Dube, Johannes Haushofer, Bilal Siddiqi, Maarten Voors
Summary: Research suggests that skepticism about the quality of health systems in developing countries contributes to higher mortality rates. By improving the perceived quality of healthcare through interventions, it is possible to promote community health and enhance the resilience of health systems during crises like epidemics.
QUARTERLY JOURNAL OF ECONOMICS
(2021)
Article
Biochemistry & Molecular Biology
Nga Yi Tsang, Wan-Fei Li, Elizabeth Varhegyi, Lijun Rong, Hong-Jie Zhang
Summary: This study identified a plant, Maesa perlarius, as an anti-Ebola virus candidate. The stem methanol extract of this plant showed inhibitory effects against Ebola-virus-pseudotyped particles (EBOVpp) and infectious Ebola virus. Further investigation led to the identification of a compound (1) as the most potent inhibitor against pseudovirion-bearing EBOV-GP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alexander Bruch, Abdulrahman A. Kelani, Matthew G. Blango
Summary: In recent years, RNA-based therapeutics have gained attention as a potential treatment for genetic disorders and infectious diseases. However, the potential of RNA-based therapeutics to treat human fungal infections has been overlooked, despite the significant mortality caused by these infections.
TRENDS IN MICROBIOLOGY
(2022)