Article
Endocrinology & Metabolism
Delia Almeida Gonzalez, Maria del Cristo Rodriguez-Perez, Manuel Fuentes Ferrer, Francisco Javier Cuevas Fernandez, Itahisa Mercelino Rodriguez, Antonio Cebrera de Leon
Summary: This study aimed to evaluate the cardiovascular protective role of irisin in the general population. A cross-sectional analysis was conducted on a large sample, and the results showed that irisin was associated with factors such as heart rate, blood pressure, body mass index, and lifestyle. These findings suggest that irisin plays a protective role in maintaining cardiometabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Monika Karczewska-Kupczewska, Agnieszka Nikolajuk, Marcin Kondraciuk, Zofia Stachurska, Marlena Dubatowka, Anna Szpakowicz, Marek Straczkowski, Irina Kowalska, Karol Kaminski
Summary: FLAIS is a useful index for assessing the cluster of insulin resistance-associated cardiovascular risk factors in the general population.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Nutrition & Dietetics
Valeria Calcaterra, Elvira Verduci, Martina Chiara Pascuzzi, Vittoria Carlotta Magenes, Giulia Fiore, Elisabetta Di Profio, Elisavietta Tenuta, Alessandra Bosetti, Carolina Federica Todisco, Enza D'Auria, Gianvincenzo Zuccotti
Summary: Obesity is characterized by excessive fat accumulation and has negative health consequences. In children, obesity is associated with an increased risk for diseases such as type 2 diabetes and cardiovascular events. The ketogenic diet has been proposed as a promising intervention for addressing metabolic and cardiovascular risk factors related to obesity.
Review
Peripheral Vascular Disease
Guanghong Jia, James R. Sowers
Summary: Insulin resistance and diabetes have been shown to increase the risk of developing hypertension, vascular stiffness, and cardiovascular disease. There are complex interactions and promotion mechanisms between these diseases, including inappropriate activation of the renin-angiotensin-aldosterone system and sympathetic nervous system.
Review
Food Science & Technology
Xiao-Feng Zhang, Yue Qi, Yong-Ping Zhang, Jin-Lan Deng, Xiao-Li Chen, Ruo-Nan Li, Qi-Lun Zhou, Jian-Ming Fan
Summary: This systematic review and meta-analysis evaluated the effects of fermented foods on metabolic outcomes in patients with diabetes and prediabetes. The results showed a significant reduction in fasting blood glucose, insulin resistance, total cholesterol, low density lipid cholesterol, and diastolic blood pressure in the intervention group. Fermented foods have the potential to improve metabolic outcomes in patients with diabetes and prediabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Domenico Trico, Alfonso Galderisi, Michelle A. Van Name, Sonia Caprio, Stephanie Samuels, Zhongyao Li, Brittany T. Galuppo, Mary Savoye, Andrea Mari, Ariel E. Feldstein, Nicola Santoro
Summary: This study aimed to investigate the effects of a low n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio diet on obese youth and its impact on metabolism. The results showed that the diet increased insulin clearance, improving hyperinsulinaemia in obese youth, independently of weight loss, glucose concentrations, and insulin secretion.
DIABETES OBESITY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Federica Sentinelli, Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Diego Bailetti, Efisio Cossu, Arcangelo Barbonetti, Maria Totaro, Olle Melander, Maria Gisella Cavallo, Marco Giorgio Baroni
Summary: Neurotensin (NT) is a small protein that regulates energy balance and functions as both a neurotransmitter in the brain and a gastrointestinal peptide. This study aimed to investigate the genetic regulation of plasma pro-NT levels. Seven sequence variations in the NT gene (NTS) were identified, including a polymorphism (rs2234762) that was more frequent in individuals with lower pro-NT levels. Carriers of the rs2234762 variant had lower pro-NT levels and reduced insulin resistance, independent of metabolic confounders. This suggests that the NTS rs2234762 gene variant may contribute to a more favorable metabolic profile in overweight and obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Judith Aron-Wisnewsky, Moritz V. Warmbrunn, Max Nieuwdorp, Karine Clement
Summary: Studying the changes in the intestinal microbiome and their relationship with obesity, diabetes, and other metabolic diseases has provided insights into the mechanisms by which alterations in the microbiome contribute to these conditions. Recent research has focused on the effects of the microbiome on lipid metabolism and the development of strategies to modify the microbiome to reverse metabolic alterations. These approaches have shown promise in mouse models of obesity and metabolic disorders and hold potential for translating to human applications to improve metabolic health.
Article
Nutrition & Dietetics
Arrigo F. G. Cicero, Federica Fogacci, Sergio D'Addato, Elisa Grandi, Elisabetta Rizzoli, Claudio Borghi
Summary: Although coffee has been linked to various cardiovascular benefits, its impact on blood pressure remains unclear. This study found that moderate coffee consumption was associated with lower systolic blood pressure, while heavy coffee consumption was associated with higher levels of systolic blood pressure.
Review
Nutrition & Dietetics
Yongbo She, Rabban Mangat, Sue Tsai, Spencer D. Proctor, Caroline Richard
Summary: Obesity is strongly linked to inflammation, impaired insulin signaling, lipid metabolism, and immune function. Recent research has provided insights into the mechanisms of immune dysfunction in obesity, using various animal and clinical models. Nutritional strategies, particularly those involving choline-rich foods, are emerging as potential ways to improve immune function in the context of obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Corinna Koebnick, Margo A. Sidell, Xia Li, Susan J. Woolford, Beatriz D. Kuizon, Poornima Kunani
Summary: This study found that high normal body weight above the 60th percentile of BMI for age is associated with increased risk of hypertension in youths, and weight gain further increases this risk.
Article
Nutrition & Dietetics
Jia Yap, Hwei Min Ng, Meredith C. Peddie, Elizabeth A. Fleming, Kirsten Webster, Tessa Scott, Jillian J. Haszard
Summary: Diet plays a significant role in hypertension, with fruit, vegetable, and milk intake being related to blood pressure. Overweight status may moderate the effects of certain dietary factors on hypertension.
Article
Endocrinology & Metabolism
Feng Wang, Mingyuan Hu, Hangju Zhu, Chao Yang, Hui Xia, Xian Yang, Ligang Yang, Guiju Sun
Summary: This study found that fish oil (FO) and perilla oil (PO) have similar protective effects on metabolic disorders and inflammation by inhibiting TLR4 signaling pathway dependent on MyD88 in mice fed a high-fat diet.
NUTRITION & DIABETES
(2021)
Article
Endocrinology & Metabolism
Annelene Govindsamy, Samira Ghoor, Marlon E. Cerf
Summary: This study investigates the effects of varying dietary fat content on the expression profiles of factors in the neonatal rat heart, revealing the role of genes and gender-related factors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xin Zhou, Mei Luo, Sha Zhou, Zhiling Cheng, Zhongpei Chen, Xiaoxia Yu
Summary: The study revealed that plasma alarin levels are associated with various biochemical markers in newly diagnosed obese and non-obese type 2 diabetes mellitus patients, suggesting a potential role in the development of T2DM.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Pediatrics
Justin R. Buendia, M. Loring Bradlee, Stephen R. Daniels, Martha R. Singer, Lynn L. Moore
Article
Environmental Sciences
Elizabeth E. Hatch, Jessica W. Nelson, M. Mustafa Qureshi, Janice Weinberg, Lynn L. Moore, Martha Singer, Thomas F. Webster
ENVIRONMENTAL HEALTH
(2008)
Article
Pediatrics
Lynn L. Moore, M. Loring Bradlee, Di Gao, Martha R. Singer
JOURNAL OF PEDIATRICS
(2008)
Article
Nutrition & Dietetics
M. Mustafa Qureshi, Martha R. Singer, Lynn L. Moore
NUTRITION & METABOLISM
(2009)
Article
Public, Environmental & Occupational Health
M. Loring Bradlee, Martha R. Singer, M. Mustafa Qureshi, Lynn L. Moore
PUBLIC HEALTH NUTRITION
(2010)
Article
Nutrition & Dietetics
Lynn L. Moore, Martha R. Singer, M. Mustafa Qureshi, M. Loring Bradlee, Stephen R. Daniels
Article
Pediatrics
Syed Ridda Hasnain, Martha R. Singer, M. Loring Bradlee, Lynn L. Moore
Article
Nutrition & Dietetics
Mengjie Yuan, R. Taylor Pickering, M. Loring Bradlee, Jabed Mustafa, Martha R. Singer, Lynn L. Moore
Summary: The study demonstrates that increasing animal protein intake, enhancing physical activity levels, and increasing skeletal muscle mass are closely associated with reduced risks of functional impairment and greater preservation of grip strength in adults over 50 years old.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
R. Taylor Pickering, M. Loring Bradlee, Martha R. Singer, Lynn L. Moore
Summary: The study found that lower sodium intake (<2500 mg/d) was not associated with a reduced risk of cardiovascular disease, while higher potassium (>= 3000 mg/d) and magnesium (>= 320 mg/d) intake were associated with a 25% and 34% lower risk of CVD, respectively. Calcium intake >= 700 mg/d showed a non-significant 19% lower risk. The results emphasize the importance of potassium and magnesium for cardiovascular health.
Article
Public, Environmental & Occupational Health
Holly C. Gooding, Hongyan Ning, Amanda M. Perak, Norrina Allen, Donald Lloyd-Jones, Lynn L. Moore, Martha R. Singer, Sarah D. de Ferranti
PREVENTIVE MEDICINE REPORTS
(2020)
Article
Endocrinology & Metabolism
Lynn L. Moore, M. Loring Bradlee, Di Gao, Martha R. Singer
Article
Endocrinology & Metabolism
L Djoussé, DK Arnett, JH Eckfeldt, MA Province, MR Singer, RC Ellison
Article
Public, Environmental & Occupational Health
LL Moore, D Gao, ML Bradlee, LA Cupples, A Sundarajan-Ramamurti, MH Proctor, MY Hood, MR Singer, RC Ellison
PREVENTIVE MEDICINE
(2003)
Article
Public, Environmental & Occupational Health
LL Moore, ML Bradlee, MR Singer, KJ Rothman, A Milunsky