Article
Food Science & Technology
Jinhyuk Na, Hye-Jeong Hwang, Mal-Soon Shin, Mingyu Kang, Jihye Lee, Geul Bang, Young Jun Kim, Yu-Jin Hwang, Kyung-A. Hwang, Youngja H. Park
Summary: White radish extract has the most beneficial effects on reducing triglycerides, while purple radish extract significantly reduces low-density lipoprotein cholesterol. Purple radish extract improves total cholesterol and high-density lipoprotein cholesterol levels, leading to a significant decrease in the atherogenic index and cardiac risk factor.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Sandra Macias-Benitez, Salvadora Navarro-Torre, Pablo Caballero, Luis Martin, Elisa Revilla, Angelica Castano, Juan Parrado
Summary: The water-soluble rice bran enzymatic extract (RBEE) was found to protect plants from ozone-induced damage, improving net photosynthetic rate and photosynthetic pigment content. It also reduced the induction of antioxidant enzyme activities in leaves due to ozone exposure. The involvement of the MAPK pathway was confirmed, supporting the protective role of RBEE against ozone damage in plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Food Science & Technology
Amnart Onsa-Ard, Rungthip Thongboontho, Narongsuk Munkong, Kanokkarn Phromnoi, Atcharaporn Ontawong, Sirinat Pengnet, Arthid Thim-Uam
Summary: This study finds that red rice bran extract may exert anti-inflammatory effects on macrophages through the inhibition of STING signaling pathway. Furthermore, it can reduce the transcription of interferon-stimulated genes, thereby decreasing the production of inflammatory cytokines.
Article
Chemistry, Multidisciplinary
Bin Wen, Yuan-ye Dang, Su-hua Wu, Yi-min Huang, Kong-yang Ma, Yi-ming Xu, Xi-Long Zheng, Xiao-yan Dai
Summary: DHC ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting inflammation, likely by targeting macrophage p65- and ERK1/2-mediated pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Food Science & Technology
Narongsuk Munkong, Piyanuch Lonan, Wirinya Mueangchang, Narissara Yadyookai, Vaiphot Kanjoo, Bhornprom Yoysungnoen
Summary: This study demonstrates that red rice bran extract (RRBE) has anti-adipogenic, anti-hypertrophic, and anti-inflammatory activities in mice. RRBE effectively attenuates high-fat diet-induced pathological adipose tissue remodeling by suppressing adipogenesis, lipid dysmetabolism, and inflammation. It may emerge as an alternative food product for combating obesity-associated adipose tissue dysfunction.
Article
Biochemistry & Molecular Biology
Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Kouji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Summary: Atherosclerosis is caused by the retention of lipoproteins and cholesterol in the subendothelial layer, leading to an inflammatory process and plaque formation. Macrophages are found to be the main producers of the anti-inflammatory cytokine IL-10 in atherosclerotic plaques. IL-10 secretion by macrophages is critical for limiting atherosclerosis progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Food Science & Technology
Mingjuan Xu, Cheng Lv, Huixia Wang, Qun Lu, Mingxia Ye, Xiaoling Zhu, Rui Liu
Summary: Peanut skin extract (PSE) plays an important role in preventing high-fat diet-induced atherosclerosis (AS), reducing the formation of atherosclerotic plaques, improving lipid metabolism disorder, and exhibiting significant anti-inflammatory effects. In addition, PSE has an impact on the composition and function of gut microbiota, which may be closely related to its anti-inflammatory effects.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Sungmin Kim, Yu-Ran Lee, Eun-Ok Lee, Hao Jin, Yeon-Hee Choi, Hee-Kyoung Joo, Byeong-Hwa Jeon
Summary: This study found that dietary capsanthin has anti-inflammatory and anti-vascular inflammation effects on atherosclerotic mice, reducing plaque formation and inflammatory marker levels.
Article
Chemistry, Applied
Hyeon Jeong Lee, Se-Rin Kim, Jea Young Park, Eun Young Park
Summary: In this study, rice and corn starches were phosphorylated with rice bran extract or STMP/STPP through dry heating. It was found that both rice bran extract and STMP/STPP increased the phosphorus concentration in the starches. The phosphorylated starches showed high peak viscosity and low pasting temperatures, with rice starch phosphorylated with rice bran extract demonstrating the most optimal parameters.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Tajendra Pal Singh, Raashid Ahmad Siddiqi, Dalbir Singh Sogi
Summary: Hydrolysis of rice bran protein concentrate by papain enzyme resulted in improved structural flexibility, antioxidant activity, and solubility of the protein hydrolysates, but decreased hydrophobicity and thermal properties. The study indicated that hydrolysis degree significantly affected the thermal, functional, and digestibility properties, with secondary structure and hydrophobicity playing important roles.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Isabelle Coornaert, Pauline Puylaert, Giullia Marcasolli, Mandy O. J. Grootaert, Peter Vandenabeele, Guido R. Y. De Meyer, Wim Martinet
Summary: Myeloid-specific RIPK1 gene deletion can reduce plaque formation and necrotic cell numbers, slowing down the progression of atherosclerosis. However, over time, the accumulation of free apoptotic and necrotic cells may result in an increase in plaque and necrotic core size.
Article
Chemistry, Applied
Liujia Xu, Yi Zhang, Vladimir Zivkovic, Mingming Zheng
Summary: Tandem continuous-flow reactors were developed for enzymatic deacidification of rice bran oil (RBO) and simultaneous production of functional oils. The immobilized Candida antarctica lipase B (CALB) on hydrophobic ordered mesoporous silicon (OMS-C-18) showed significantly increased catalytic activity and temperature tolerance compared to Novozym 435. The tandem continuous-flow enzymatic reactors effectively removed free fatty acid and increased the content of phytosterol ester and diacylglycerol in RBO, while retaining a higher percentage of gamma-oryzanol compared to traditional alkali refining.
Article
Pharmacology & Pharmacy
Li-Qun Lu, a Nian-Sheng Li, a Ming-Rui Li, Jiao-Yang Peng, Li-Jing Tang, Xiu-Ju Luo, Jun Peng
Summary: Impaired endothelium-dependent vasodilation in atherosclerosis is a high-risk factor for myocardial infarction and ischemic stroke. DL-3-n-butylphthalide (NBP) improves endothelium-dependent vasodilation by suppressing inflammation, endothelial necroptosis, and apoptosis in atherosclerosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Lei Zheng, XingYi Zhu, Jialu Wang, Weike Su
Summary: The study developed mechanochemical-assisted extraction (MCAE) and mechanochemical-assisted enzyme catalysis (MCAEC) methods for extracting and enzymatic hydrolysis of calcium phytate from defatted rice bran, respectively. The optimized MCAE conditions resulted in a calcium phytate yield of 97.0 mg/g, while the optimized MCAEC conditions achieved a hydrolysis rate of 39.7% for calcium phytate. Compared to traditional methods, MCAE and MCAEC demonstrated higher yields and hydrolysis rates, respectively.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cedric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Summary: GSDMD plays a critical role in atherosclerotic plaque destabilization, with its deficiency leading to increased plaque stability and apoptosis. Targeting GSDMD may be an effective approach to limit the transition to an inflammatory, vulnerable plaque phenotype.
Article
Cardiac & Cardiovascular Systems
Daniel Lavall, Nicola H. Vosshage, Romy Gessner, Stephan Stoebe, Sebastian Ebel, Timm Denecke, Andreas Hagendorff, Ulrich Laufs
Summary: Native T1 mapping in patients with left ventricular hypertrophy has high diagnostic accuracy for detecting cardiac amyloidosis.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Paulina E. Stuerzebecher, Jessica J. Schorr, Sven H. G. Klebs, Ulrich Laufs
Summary: This study aimed to characterize patients undergoing Lp(a) testing and evaluate the impact of Lp(a) testing on treatment changes and subsequent ASCVD events. The study found that Lp(a) testing is rarely performed even in patients with high cardiovascular risk. Patients tested for Lp(a) have more comorbidities and a higher ASCVD risk. Lp(a) testing is associated with more intensive preventive treatment and positive effects on clinical outcomes and survival.
Editorial Material
Cardiac & Cardiovascular Systems
Paulina E. Stuerzebecher, Julius L. Katzmann, Ulrich Laufs
EUROPEAN HEART JOURNAL
(2023)
Letter
Hematology
Michael Metze, Annelie Siegemund, Thomas Siegemund, Tristan Kloeter, Stephan Stoebe, Ulrich Laufs, Sirak Petros, Christian Pfrepper
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Letter
Immunology
Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Rafael Kramann, Christina Koerbel, Emmanuel Ampofo, Matthias W. Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Gaul, Guenther Silbernagel, Martina Sester, Urban Sester, Gunter Assmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D. Menger, Lucia Rohrer, Winfried Maerz, Michael Boehm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A. Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer
Article
Medicine, General & Internal
S. E. E. Nissen, A. M. Lincoff, D. Brennan, K. K. K. Ray, D. Mason, J. J. P. Kastelein, P. D. D. Thompson, P. Libby, L. Cho, J. Plutzky, H. E. E. Bays, P. M. M. Moriarty, V Menon, D. E. E. Grobbee, M. J. J. Louie, C-F Chen, N. Li, L. A. Bloedon, P. Robinson, M. Horner, W. J. J. Sasiela, J. McCluskey, D. Davey, P. Fajardo-Campos, P. Petrovic, J. Fedacko, W. Zmuda, Y. Lukyanov, S. J. J. Nicholls
Summary: This study demonstrates that the ATP citrate lyase inhibitor Bempedoic acid can significantly reduce low-density lipoprotein cholesterol levels and is associated with a low incidence of muscle-related adverse events. Among patients unable or unwilling to take statins, Bempedoic acid treatment significantly reduces the risk of major adverse cardiovascular events.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Maciej Banach, Peter E. Penson, Michel Farnier, Zlatko Fras, Gustavs Latkovskis, Ulrich Laufs, Francesco Paneni, Paolo Parini, Matteo Pirro, Zeljko Reiner, Michal Vrablik, Carlos Escobar
Summary: Cardiovascular disease (CVD) is a chronic non-communicable disease and the leading cause of disability and mortality worldwide. The current lipid-lowering treatments need improvement, and bempedoic acid, as a new approach to reduce lipid levels, has the potential to lower the risk of CVD.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Laura Ueberham, Andreas Hagendorff, Karin Klingel, Ingo Paetsch, Cosima Jahnke, Theresa Kluge, Hans Ebbinghaus, Gerhard Hindricks, Ulrich Laufs, Borislav Dinov
Summary: Cardiac sarcoidosis can mimic any cardiomyopathy due to nonhomogeneous distribution of inflammation in the heart. The current diagnostic criteria are inconsistent and partly nonspecific and insensitive. In addition to the diagnostic challenges, there are controversies surrounding the causes, genetic and environmental background, and natural evolution of the disease. This review highlights the current understanding and research gaps in the pathophysiology of cardiac sarcoidosis that will be relevant for future diagnostics and research.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Kausik K. Ray, Inaam Haq, Aikaterini Bilitou, Marius C. Manu, Annie Burden, Carlos Aguiar, Marcello Arca, Derek L. Connolly, Mats Eriksson, Jean Ferrieres, Ulrich Laufs, Jose M. Mostaza, David Nanchen, Ernst Rietzschel, Timo Strandberg, Hermann Toplak, Frank L. J. Visseren, Alberico L. Catapano
Summary: The SANTORINI study found that in Europe between 2020 and 2021, statin monotherapy was the main approach to lipid management for high-risk and very high-risk cardiovascular patients, with only one-fifth achieving the recommended LDL-C goals. The study results raised questions about whether there have been changes in the treatment landscape or if gaps still exist.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Clinical Neurology
Manuel C. Olma, Serdar Tuetuencue, Ulrike Grittner, Claudia Kunze, Muhammad Jawad-Ul-Qamar, Paulus Kirchhof, Joachim Roether, Goetz Thomalla, Roland Veltkamp, Ulrich Laufs, Darius G. Nabavi, Peter U. Heuschmann, Matthias Endres, Karl Georg Haeusler
Summary: Little is known about the extent and standardization of routine cardiac diagnostic work-up at certified stroke-units in Germany. This study analyzed the routine diagnostic work-up at different stroke centres in Germany and found that detection of atrial fibrillation (AF) varied among the centres, with lower detection rates in university-based comprehensive stroke centres compared to non-university-based and primary stroke centres. The use of echocardiography and Holter-ECG monitoring also differed among the centres.
NEUROLOGICAL RESEARCH AND PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Uhe, Katrin Wasser, Mark Weber-Krueger, Wolf-Ruediger Schaebitz, Martin Koehrmann, Johannes Brachmann, Ulrich Laufs, Martin Dichgans, Goetz Gelbrich, David Petroff, Christiane Prettin, Dominik Michalski, Andrea Kraft, Thorleif Etgen, Peter D. Schellinger, Hassan Soda, Florian Bethke, Michael Ertl, Bernd Kallmuenzer, Martin Grond, Katharina Althaus, Gerhard F. Hamann, Meinhard Mende, Marcus Wagner, Sonja Groeschel, Timo Uphaus, Klaus Groeschel, Rolf Wachter
Summary: This study aims to evaluate whether risk-adapted, intensified heart rhythm monitoring with consequent guideline conform treatment can reduce the recurrence of cardioembolism. The study will include patients aged 60 and above who have had a symptomatic ischemic stroke within the last 30 days. They will be randomly assigned to either an intervention group or a control group.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
U. Makhmudova, U. Schatz, N. Perakakis, U. Kassner, F. Schumann, C. Axthelm, P. Stuerzebecher, D. L. Sinning, A. Doevelaar, B. Rohn, T. Westhoff, A. Vogt, M. Scholl, U. Kaestner, J. -A. Geiling, K. Stach, J. Mensch, E. Lorenz, C. Paitazoglou, I. Eitel, A. Baessler, E. Steinhagen-Thiessen, W. Koenig, P. C. Schulze, U. Landmesser, U. Laufs, Oliver Weingaertner, German Inclisiran Network GIN
Summary: Inclisiran, a new drug that targets PCSK9 mRNA, effectively reduces LDL-C levels in patients with hypercholesterolemia. In a German study, inclisiran demonstrated a median LDL-C reduction of 35.5% at 3 months and 26.5% at 9 months. Patients previously treated with PCSK9 antibodies showed lower LDL-C reductions compared to statin-treated patients at the 3-month mark.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander Kogel, Moritz Machatschek, Ronja Scharschmidt, Carolin Wollny, Florian Lordick, Mohamed Ghanem, Ulrich Laufs, Sven Fikenzer
Summary: This study found that physical exercise after COVID-19 infection can safely and effectively improve maximal exercise capacity and quality of life in patients. Fatigue decreases over time. Additionally, individuals who participated in the exercise program had significantly higher levels of physical activity during the follow-up period compared to those in the control group.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Klaus G. Parhofer, Ulrich Laufs
Summary: The treatment of dyslipidemias is crucial for the prevention of cardiovascular disease. Evaluation of lipid status and monitoring of treatment effects can guide therapy. The main goal is to lower LDL-cholesterol through lifestyle changes and medication.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
J. Kandels, M. Metze, A. Hagendorff, R. P. Marshall, P. Hepp, U. Laufs, S. Stoebe
Summary: In addition to LV ejection fraction (LVEF), global longitudinal strain (GLS) and global myocardial work index (GWI) are crucial for evaluating left ventricular (LV) function in athletes. This study investigated the effects of upright posture on GLS and GWI during echocardiography. The results showed that GLS and GWI were lower in upright posture, particularly in the mid-basal inferior and/or posterolateral segments. These findings highlight the importance of considering the impact of upright posture in athletes' echocardiographic assessments.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)