Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 15, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201700003
Keywords
bioinspired surfaces; cancer cell recognition; hierarchical structures; pollen; soft lithography
Funding
- National Natural Science Foundation of China [21501184, 21425314, 21434009, 21421061, 21504098]
- Key Research Program of the Chinese Academy of Sciences [KJZD-EW-M01]
- MOST [2013YQ190467]
- Top-Notch Young Talents Program of China
- Beijing Municipal Science & Technology Commission [Z161100000116037]
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The efficient recognition and isolation of rare cancer cells holds great promise for cancer diagnosis and prognosis. In nature, pollens exploit spiky structures to realize recognition and adhesion to stigma. Herein, a bioinspired pollen-like hierarchical surface is developed by replicating the assembly of pollen grains, and efficient and specific recognition to target cancer cells is achieved. The pollen-like surface is fabricated by combining filtering-assisted assembly and soft lithography-based replication of pollen grains of wild chrysanthemum. After modification with a capture agent specific to cancer cells, the pollen-like surface enables the capture of target cancer cells with high efficiency and specificity. In addition, the pollen-like surface not only assures high viability of captured cells but also performs well in cell mixture system and at low cell density. This study represents a good example of constructing cell recognition biointerfaces inspired by pollen-stigma adhesion.
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