Article
Chemistry, Multidisciplinary
Masahiko Asada, Hisakazu Tanaka, Yukie Suwa, Sachiko Irifune, Shigehito Osawa, Hidenori Otsuka
Summary: Recently, highly hydrophilic adhesive has been developed as a pigment dispersant in water-based inks. The critical issue is how to control the affinity balance of the adhesive between the pigments and aqueous media. Therefore, increasing the solubility of low acid-value hydrophobic polymers is important for ink design.
APPLIED SCIENCES-BASEL
(2023)
Review
Agriculture, Multidisciplinary
Hui Sun, Qingyu Xu, Mingguang Ren, Shoujuan Wang, Fangong Kong
Summary: Lignin, the second most abundant natural polymer, has gained considerable attention recently due to its reproducibility, safety, and biodegradability. Research is focusing on developing new lignin applications to replace petroleum-based chemicals. The synthesis and applications of amphiphilic lignin-derived polymers, which have various industrial uses, are reviewed in this article, providing a theoretical reference for utilizing high-added-value and high-performance lignin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Polymer Science
Wei Chen, Peng Liu
Summary: The study focused on the synthesis of PEGylated dendritic polyurethane for ultrasound-triggered localized drug delivery. The nanomedicine showed excellent intracellular drug release performance in simulated tumor environment and enhanced tumor growth inhibition on HepG2 cells compared to free DOX.
Article
Chemistry, Multidisciplinary
Liu Tan, Jinling Fan, Yuqing Zhou, Di Xiong, Manzhen Duan, Ding Hu, Zhimin Wu
Summary: A new type of reversible cross-linked and pH-responsive polymeric micelle was synthesized for targeted delivery of curcumin. The micelle exhibited excellent stability and reversibility of pH-responsiveness in solutions with different pH values. Simulation methods were employed to investigate the self-assembly process and pH-responsive behavior of the micelle.
Article
Biochemistry & Molecular Biology
Hamid Rashidzadeh, Farzad Seidi, Mohammadreza Ghaffarlou, Marziyeh Salehiabar, Jalil Charmi, Kadir Yaray, Hamed Nosrati, Yavuz Nuri Ertas
Summary: As noble metals, high atomic number elements can localize X-ray radiation within tumor cells by exploiting different mechanisms. In this study, alginate-coated platinum nanoparticles were synthesized and used as a radiosensitizer to enhance X-ray therapeutic efficacy in breast cancer. The nanoparticles not only improved biocompatibility and stability, but also induced higher levels of intracellular ROS and enhanced cancer cell death under X-ray irradiation. Both in vitro and in vivo results demonstrated the radiosensitizing properties of the nanosystem. The importance of radiosensitizers for improving radiotherapy outcomes was highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Irrum Mushtaq, Zareen Akhter, Muhammad Farooq, Farukh Jabeen, Ashfaq Ur Rehman, Sadia Rehman, Sidra Ayub, Bushra Mirza, Muhammad Siddiq, Farasat Zaman
Summary: A tunable amphiphilic ABA-type triblock copolymer, named P2L, was synthesized successfully. It is non-toxic to human blood cells and can encapsulate and release dexamethasone drug.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yu Wang, Guangdong Zhu, Shun Wang, Jianjun Xie, Zhan Chen, Ying Shi
Summary: The quaternary amphiphilic block copolymer prepared by RAFT method improves the anti-hydrolysis and dispersion properties of AlN powders modified by copolymers. After micro-crosslinking treatment, the modified AlN powder shows outstanding stability in hot water and significantly improved powder particle agglomeration.
Article
Polymer Science
R. Simonutti, D. Bertani, R. Marotta, S. Ferrario, D. Manzone, M. Mauri, M. Gregori, A. Orlando, M. Masserini
Summary: This study investigates the effect of using different common solvents on the self-assembly behavior of block copolymer nanoparticles, finding that the hydrogen bonding ability of the solvent strongly influences the size and shape of the particles, as well as their cytotoxicity.
Article
Polymer Science
Makoto Obata, Satoshi Masuda, Masaki Takahashi, Kohei Yazaki, Shiho Hirohara
Summary: The study investigated the impact of hydrophobic R groups on various properties of polymeric micelles loaded with ZnPc for photodynamic therapy. The presence of aromatic R groups led to larger micelles with loosely packed ZnPc aggregates, resulting in higher release and enhanced photodynamic effect compared to micelles with aliphatic R groups.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yunpeng Feng, Sean P. Quinnell, Alison M. Lanzi, Arturo J. Vegas
Summary: Structured nanoassemblies are biomimetic structures with potential applications in fields ranging from nanomedicine to catalysis. Self-assembling ABC-type alginate-based triblock copolymers, with the backbones of three distinct biomaterials, were synthesized using a facile conjugation approach. These particles provide a versatile platform for co-encapsulation of hydrophilic and hydrophobic small molecules, spatiotemporal release, and show promise as a drug delivery system for combination therapy.
Article
Chemistry, Physical
Shinnosuke Nishimura, Yoshihiko Murakami
Summary: Sheets have advantages over traditional material forms, but a simple method for forming porous structures has not been established. Research has found that under specific conditions, porous structures of different pore sizes can be formed on the surface, which can be used for the development of materials with diverse functions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Christian Hils, Joachim Schmelz, Markus Drechsler, Holger Schmalz
Summary: This study presents a facile method for producing worm-like Janus micelles through crystallization-driven self-assembly of a double-crystalline triblock terpolymer. These amphiphilic Janus micelles exhibit excellent interfacial activity and can be easily produced in solution through a simple heating and cooling protocol.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Yibo Zhou, Keyi Yin, Hao Dong, Sheng Yang, JunBin Li, Jinqiu Luo, Yi Li, Ronghua Yang
Summary: The development of a peptide-linked amphiphilic block copolymer-based probe (PABC) allowed for long-lasting bioluminescence imaging of FAP in vivo, overcoming the transient nature of current FAP-responsive BL probes. With high sensitivity and the ability to distinguish cancer cells from normal ones, the PABC can persistently image FAP in living cells and has potential for screening FAP inhibitors and diagnosing FAP-related diseases in the future.
ANALYTICAL CHEMISTRY
(2021)
Article
Polymer Science
Chih-Hao Chang, Chih-Hung Chang, Ya-Wen Yang, Hsuan-Yu Chen, Shu-Jyuan Yang, Wei-Cheng Yao, Chi-Yang Chao
Summary: This study successfully synthesized a novel polystyrene-block-quaternized polyisoprene amphipathic block copolymer and controlled the antibacterial activity by regulating the block composition, side chain length, and polymer morphology. The polymers with N,N-dimethyldodecylamine side chains formed polymersome structures in aqueous solutions, exhibiting the best inhibiting bacterial growth efficiency.
Article
Chemistry, Multidisciplinary
Qian Wang, Zhiliang Gao, Kaijie Zhao, Peiyu Zhang, Qi-Zhi Zhong, Qun Yu, Shumei Zhai, Jiwei Cui
Summary: This study demonstrates the fabrication of a functional nanosystem that can self-supply oxygen and deliver photosensitizers, leading to improved efficiency of photodynamic therapy against solid tumors.
CHINESE CHEMICAL LETTERS
(2022)
Article
Polymer Science
Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka
Summary: This study integrates the protective effect against nucleases and the endosomal escape capability into a single polyplex by fine-tuning the catiomer chemical structure and incorporating the endosomal escape modality for efficient mRNA delivery. The methylene spacer length on the catiomer side chain significantly affects the nuclease stability of the polyplex, and introducing a charge-conversion polymer can improve endosomal escape efficiency by approximately 80-fold in cultured cells. The system synergizes PLO's protective effect against nucleases and CCP's endosomal escape capability, leading to enhanced protein expression efficiency from mRNA delivery.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Engineering, Multidisciplinary
Yu BoCheng, Sun Mei, Pan RuHao, Tian JiaMin, Zheng FengYi, Huang Dong, Lyu FengJiao, Zhang ZhiTong, Li JunJie, Chen Qing, Li ZhiHong
Summary: This study proposes a method to address the issue of breakage in nanodevice fabrication on the TEM chip and successfully fabricates various nanodevices. Additionally, it investigates and enhances the pressure tolerance of the window membrane, demonstrating typical applications of MoS2 devices.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2022)
Article
Polymer Science
Jingbo Wang, Qinghao Zhou, Xiang Li, Debabrata Dutta, Zhishen Ge
Summary: In this study, researchers integrated self-assembled peptides, glutathione-sensitive disulfide bonds, and mitochondrial targeting moieties into an amphiphilic block copolymer to construct nanocarriers for loading anticancer drugs. The nanocarriers can reassemble into fibers inside cells and target mitochondria, leading to the inhibition of tumor cells by releasing drugs and inducing mitochondrial dysfunction.
Article
Chemistry, Multidisciplinary
Debabrata Dutta, Jingbo Wang, Xiang Li, Qinghao Zhou, Zhishen Ge
Summary: This study presents the use of covalent organic framework (COF) nanoparticles loaded with the near-infrared (NIR) dye cypate for oxygen-independent generation of singlet oxygen (O-1(2)), allowing for concurrent photothermal therapy (PTT) and photodynamic therapy (PDT) under NIR irradiation. The COF nanoparticles protect cypate from photodegradation and improve its photostability and photothermal conversion efficiency. Upon NIR irradiation, the COF nanoparticles release the stored O-1(2) and induce ablation of tumors through oxygen-independent concurrent PTT/PDT.
Article
Chemistry, Multidisciplinary
Xiang Li, Qinghao Zhou, Abd Al-Wali Mohammed M. Japir, Debabrata Dutta, Nannan Lu, Zhishen Ge
Summary: This study develops ROS-responsive nanocomplexes that can release antibodies and enzymes through Fenton reaction, improving the efficacy of immunotherapy for tumors. The nanocomplexes can generate reactive oxygen species at tumor sites and activate the immunosuppressive tumor microenvironment through immunogenic cell death, resulting in significant tumor suppression.
Article
Biochemical Research Methods
Jean Felix Mukerabigwi, Rui Tang, Yufei Cao, Fathelrahman Mohammed, Qinghao Zhou, Min Zhou, Zhishen Ge
Summary: Multi-drug resistance (MDR) is a major obstacle in cancer therapy, and overcoming MDR is highly desired. The development of a polyprodrug that can target both cancer cells and mitochondria has shown great potential in reversing MDR. The polyprodrug, named TF@CNM + DOX, was designed using folic acid (FA) and tetraphenylphosphonium (TPP) targeting moieties to sequentially deliver CNM and DOX to cancer cells and mitochondria, respectively. This dual-targeting approach enhances intracellular oxidative stress and enables ROS-responsive drug release, effectively inhibiting the growth of DOX-resistant tumors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qinghao Zhou, Debabrata Dutta, Yufei Cao, Zhishen Ge
Summary: In this study, polymeric metal-organic framework nanoparticles were used as carriers for the combination of photodynamic therapy and enhanced STING activation, resulting in improved immunotherapeutic efficacy. The nanoparticles showed excellent stability and could release the STING agonist and induce cell apoptosis under light irradiation. The combination of photodynamic-immunotherapy reversed the immunosuppressive tumor microenvironment and enhanced endogenous STING activation, effectively suppressing the growth of primary and distant tumors.
Article
Polymer Science
Kexiang Chen, Chenhui Cui, Zhen Li, Zhe Song, Qiang Zhang, Youshen Wu, Zhishen Ge, Yilong Cheng, Yanfeng Zhang
Summary: Multicomponent polymerization (MCP) is a widely used method to synthesize multifunctional polymers, offering high efficiency, mild reaction conditions, and high yield. In this study, a novel covalent adaptable network (CAN) with dynamic thioaminal covalent bonds was developed through a simple one-pot thiol-aldehyde-amine MCP. The obtained thioaminal CANs showed a tensile strength of up to 45 MPa and exhibited reprocessability, recyclability, and reconfigurable shape memory behaviors. The thiol-aldehyde-amine MCP presents a simple and efficient strategy for preparing versatile thioaminal CANs.
Review
Pharmacology & Pharmacy
Panyue Wen, Wendong Ke, Anjaneyulu Dirisala, Kazuko Toh, Masaru Tanaka, Junjie Li
Summary: The stealth effect is crucial for enhancing the capabilities of nanomaterials in drug delivery applications. Through analyzing the efficiency and factors involved, we propose an integrated perspective on engineering stealth nanomaterials. The analysis reveals a common pharmacokinetics behavior, known as the pseudo-stealth effect, which leads to a rapid drop in blood concentration despite a relatively long b-phase. We suggest that a holistic approach, considering surface structure and geometry, is essential for improving the stealth effect.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Anum Kayani, Arsalan Raza, Jiale Si, Debabrata Dutta, Qinghao Zhou, Zhishen Ge
Summary: Polymersomes have been extensively studied as nanocarriers for drug delivery for two decades. Although they have many advantages, including high stability and simultaneous encapsulation of hydrophilic and hydrophobic drugs, they often face issues with non-targeted delivery and poor membrane permeability. Recent advancements in surface functionalization and membrane permeability control have addressed these challenges and improved the efficiency of drug delivery using polymersomes. This review provides a detailed overview of the role of polymersome membranes and future developments in promoting them as in vivo drug delivery nanocarriers.
Article
Polymer Science
Zhen Li, Yanxiu Wen, Zhe Song, Chuang Zhang, Chenhui Cui, Dongxu An, Zhishen Ge, Yilong Cheng, Qiang Zhang, Yanfeng Zhang
Summary: The researchers have developed a dynamic cross-linked polyethylene material (PE-MA-Epo) with high dielectric constant and polarization capability, which can fully recover its performance after electrical tree healing. This material demonstrates performance comparable to biaxially oriented polypropylene films and shows great potential for applications in next-generation electrical equipment.
Article
Chemistry, Multidisciplinary
Yufei Cao, Jiale Si, Moujiang Zheng, Qinghao Zhou, Zhishen Ge
Summary: Radiotherapy is widely used in the treatment of various cancers and has the advantages of precise controllability and deep tissue penetration. However, it is limited by side effects and tumor hypoxia. The combination of radiotherapy and other modalities can improve therapeutic efficacy and reduce toxicity.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kaijie Zhao, Mengqi Li, Peiyu Zhang, Jiwei Cui
Summary: Polyethylene glycol (PEG) is commonly used for surface modification to reduce nonspecific interactions with biomolecules, microorganisms, and cells. This study presents a sticktight-inspired PEGylation strategy for creating low-fouling coatings. The number of arms in the PEG molecule plays a crucial role in enhancing surface PEGylation and improving the coating's resistance against protein, mammalian cell, and bacterial adhesion.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhiliang Gao, Xiaoyu Li, Kaijie Zhao, Huimin Geng, Peiyu Zhang, Yi Ju, Pie Huda, Christopher B. Howard, Kristofer J. Thurecht, Muthupandian Ashokkumar, Jingcheng Hao, Jiwei Cui
Summary: Confined sono-polymerization is used to prepare poly(ethylene glycol) nanoparticles within water-in-oil microemulsion, followed by post-functionalization with a bispecific antibody for targeted delivery of photosensitizers. The nanoparticles can specifically target breast cancer cells, inhibiting cancer cell growth through laser irradiation.
CHEMICAL COMMUNICATIONS
(2022)
