Journal
CHINESE CHEMICAL LETTERS
Volume 33, Issue 4, Pages 1917-1922Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.11.040
Keywords
Metal-phenolic network (MPN); Photodynamic therapy (PDT); Capsule; Oxygen self-supply; Drug delivery
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This study demonstrates the fabrication of a functional nanosystem that can self-supply oxygen and deliver photosensitizers, leading to improved efficiency of photodynamic therapy against solid tumors.
The intrinsic hypoxic tumor microenvironment and limited accumulation of photosensitizers (PSs) result in unsatisfied efficiency of photodynamic therapy (PDT). To enhance the PDT efficiency against solid tumors, a functional oxygen self-supplying and PS-delivering nanosystem is fabricated via the combination of catalase (CAT), chlorin e6 (Ce6) and metal-phenolic network (MPN) capsule. It is demonstrated that the CAT encapsulated in the capsules (named CCM capsules) could catalyze the degradation of hydrogen peroxide (H2O2) to produce molecular oxygen (O-2), which could be converted into cytotoxicity reactive oxygen species (ROS) by surface-loaded Ce6 under 660 nm laser irradiation, leading to synergistic anticancer effects in vitro and in vivo. Therefore, the application of CCM capsule could be a promising strategy to improve PDT effectiveness. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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