A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding

Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease

(2016) Katarzyna Grychowska et al.   ACS Chemical Neuroscience

Computational Tools To Model Halogen Bonds in Medicinal Chemistry

(2015) Melissa Coates Ford et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and function of serotonin G protein-coupled receptors

(2015) John D. McCorvy et al.   PHARMACOLOGY & THERAPEUTICS

The 5-HT6 receptor antagonism approach in Alzheimer's disease

(2014) D. Marazziti et al.   DRUGS OF THE FUTURE

Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease

(2014) Bellinda Benhamú et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serotonergic 5-HT7 receptors and cognition

(2014) Antonella Gasbarri et al.   REVIEWS IN THE NEUROSCIENCES

New Serotonin 5-HT1A Receptor Agonists Endowed with Antinociceptive Activity in Vivo

(2013) Margarita Valhondo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Molecular Recognition at Serotonin Receptors

(2013) C. Wang et al.   SCIENCE

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Impact of Helix Irregularities on Sequence Alignment and Homology Modeling of G Protein-Coupled Receptors

(2012) Angel Gonzalez et al.   CHEMBIOCHEM

Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters

(2012) Arnau Cordomí et al.   Journal of Chemical Theory and Computation

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-HT6 receptor and cognition

(2011) Xabier Codony et al.   CURRENT OPINION IN PHARMACOLOGY

Performance Assessment of Semiempirical Molecular Orbital Methods in Describing Halogen Bonding: Quantum Mechanical and Quantum Mechanical/Molecular Mechanical-Molecular Dynamics Study

(2011) Mahmoud A. A. Ibrahim   Journal of Chemical Information and Modeling

Benzimidazole Derivatives as New Serotonin 5-HT6Receptor Antagonists. Molecular Mechanisms of Receptor Inactivation

(2010) Tania de la Fuente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Molecular Probes for the Human 5-HT6Receptor

(2010) Henar Vázquez-Villa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment

(2009) X.-P. Huang et al.   MOLECULAR PHARMACOLOGY

Halogen bonds as orthogonal molecular interactions to hydrogen bonds

(2009) Andrea Regier Voth et al.   Nature Chemistry

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

(2008) Kevin C.F. Fone   NEUROPHARMACOLOGY