Article
Neurosciences
Yu Zhao, Chuanling Wang, Wenbo He, Zhiyou Cai
Summary: Minocycline mitigates Alzheimer's-like pathology by limiting the activation of the Cdk5/p25 signaling pathway and improves cognitive deficits.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Mubashir Ahmad, Benjamin Thilo Krueger, Torsten Kroll, Sabine Vettorazzi, Ann-Kristin Dorn, Florian Mengele, Sooyeon Lee, Sayantan Nandi, Dilay Yilmaz, Miriam Stolz, Naveen Kumar Tangudu, David Carro Vazquez, Johanna Pachmayr, Ion Cristian Cirstea, Maja Vujic Spasic, Aspasia Ploubidou, Anita Ignatius, Jan Tuckermann
Summary: This study identified Cdk5 as a suppressor of osteoblast differentiation through unbiased kinome RNAi screening. Cdk5 knockdown or inhibition enhanced osteoblastogenesis in vitro, and it was found to regulate osteoblast differentiation through the MAPK pathway. These findings suggest that Cdk5 may be a potential therapeutic target for treating osteoporosis and improving fracture healing.
Article
Biochemistry & Molecular Biology
Takahisa Hirokawa, Taeko Horie, Yurie Fukiyama, Masashi Mimura, Shinji Takai, Teruyo Kida, Hidehiro Oku
Summary: The study identified that the overactivation of Cdk5 is associated with the development of tauopathies. Roscovitine, a Cdk5 inhibitor, reduces the phosphorylation level of tau protein and mitigates the pathologic phosphorylation of tau by inhibiting the calpain signaling pathway, thereby alleviating the degeneration of RGCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Li Lin, Xiaodong Liu, Xuejun Cheng, Yujing Li, Marla Gearing, Allan Levey, Xiaoli Huang, Ying Li, Peng Jin, Xuekun Li
Summary: In this study, the altered expression and misregulation of miR-650 in Alzheimer's disease (AD) brains were observed. Bioinformatic analysis predicted that miR-650 targets three AD-associated genes, and experimental confirmation showed that miR-650 significantly reduces their expression levels in vitro. Overexpression of miR-650 was shown to alter CDK5 levels and ameliorate AD pathologies in transgenic mice. These findings suggest that miR-650 influences AD pathogenesis through regulation of CDK5.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christine A. Mills, Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, Michael J. Emanuele
Summary: This study identified SIRT5 as a novel substrate of Cyclin F, which regulates cell cycle and metabolism through interaction with Cyclin F. The knockout of SIRT5 results in changes in cell cycle signaling congruent with S and G2/M phase increase. These findings suggest a connection between SIRT5, cell cycle regulation, and metabolism.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chunli Chen, Xiaoxia Peng, Jiayu Tang, Zhiping Hu, Jieqiong Tan, Liuwang Zeng
Summary: This study indicates that inhibition of CDK5 can provide neuroprotection by regulating the phosphorylation of Drp1S616, mitigating mitochondrial fragmentation and apoptosis induced by cerebral ischemia. The findings help in the development of drug targeting the CDK5 signaling pathway for clinical use in treating cerebral ischemia.
Article
Physiology
Satoko Hayashi, Shotaro Sakata, Shotaro Kawamura, Yukako Tokutake, Shinichi Yonekura
Summary: This study reveals the mechanism by which muscle cells exit the cell cycle after differentiation through the degradation of Id3 by XBP1u.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lorela Ciraku, Zachary A. Bacigalupa, Jing Ju, Rebecca A. Moeller, Giang Le Minh, Rusia H. Lee, Michael D. Smith, Christina M. Ferrer, Sophie Trefely, Luke T. Izzo, Mary T. Doan, Wiktoria A. Gocal, Luca D'Agostino, Wenyin Shi, Joshua G. Jackson, Christos D. Katsetos, Kathryn E. Wellen, Nathaniel W. Snyder, Mauricio J. Reginato
Summary: This study identifies a novel mechanism in which OGT regulates acetate-dependent acetyl-CoA and lipid production by regulating phosphorylation of ACSS2 by CDK5. The OGT/CDK5/ACSS2 pathway may be a potential target for treating altered metabolic dependencies in brain tumors.
Review
Biochemistry & Molecular Biology
Jorrit M. Enserink, Pierre Chymkowitch
Summary: Cdk1 is a master regulator of the cell cycle, controlling progression through different phases. It also directly regulates RNA polymerase activity, which is important for protein synthesis and meeting cellular demands. This regulation promotes cell cycle entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Sandro Capellmann, Roland Sonntag, Herdit Schueler, Steffen K. Meurer, Lin Gan, Marlies Kauffmann, Katharina Horn, Hiltrud Koenigs-Werner, Ralf Weiskirchen, Christian Liedtke, Michael Huber
Summary: Mast cells (MCs) are heterogeneous immune cells with different protease repertoires and receptor expressions. A new cell line, PMC-306, derived from primary peritoneal MCs, can be used to study PMC function and tumorigenic processes associated with MC leukemia.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Michal Zaluski, Izabela Gutowska
Summary: Cyclin-dependent kinases are crucial in various cellular processes and their dysregulation can lead to diseases, making them potential drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Riheb Jabeur, Caroline Corbel, Pascal Loyer, Annabelle Le Parc, Adelaide Le Grand, Arnaud Comte, Stephane Bach, Gwenaelle Andre-Leroux, Olivier Sire, Hedi Ben Mansour, Veronique Le Tilly
Summary: Tamoxifen modulates the phosphorylation status of TAU protein in Alzheimer's disease and inhibits CDK5 kinase activity. Two novel inhibitors of CDK5/p25 complex are identified, which can reduce the risk of recurrence of ER+ breast cancers and prevent drawbacks induced by tamoxifen exposure.
Article
Oncology
Angela M. Carter, Nilesh Kumar, Brendon Herring, Chunfeng Tan, Rachael Guenter, Rahul Telange, Wayne Howse, Fabrice Viol, Tyler R. McCaw, Hayden H. Bickerton, Priyanka Gupta, Frank Gillardon, Eugene A. Woltering, Deepti Dhall, John Totenhagen, Ronadip R. Banerjee, Elizabeth M. Kurian, Sushanth Reddy, Herbert Chen, Joerg Schrader, J. Bart Rose, M. Shahid Mukhtar, James A. Bibb
Summary: Pancreatic neuroendocrine tumors (PanNETs) are a type of tumor that arises from hormone-secreting islet cells of the pancreas. A new inducible, conditional mouse model of PanNETs has been developed, which will facilitate molecular delineation of Cdk5-dependent PanNETs and the development of new targeted therapeutics.
Article
Microbiology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study investigated the functional roles of Giardia lamblia CDKs (GlCDKs) and their cognate cyclins. Using morpholino-mediated knockdown and coimmunoprecipitation, the functions of GlCDK1 and GlCDK2 were distinguished. GlCDK1 with Glcyclin 3977 plays a crucial role in flagellum formation and cell cycle control of G. lamblia, while GlCDK2 with Glcyclin 22394/6584 is involved in cell cycle control.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Ines H. Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Duester, Jinhua Wang, Nathanael S. Gray, Matthias Geyer
Summary: Abemaciclib, a CDK inhibitor for breast cancer treatment, also targets HIPKs and DYRK1A. HIPKs play a role in signal pathway regulation, and DYRK1A is inhibited by Abemaciclib in vitro to a similar extent as Cdk4/Cdk6.
NATURE COMMUNICATIONS
(2021)
