CDK5 inhibition protects against OGDR induced mitochondrial fragmentation and apoptosis through regulation of Drp1S616 phosphorylation

CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP+

(2020) Shang-Hsun Yang et al.   MOLECULAR NEUROBIOLOGY

Mitochondria as a therapeutic target for ischemic stroke

(2019) Zhi He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia

(2019) Bich Na Shin et al.   Scientific Reports

The role of Cdk5-mediated Drp1 phosphorylation in Aβ1-42 induced mitochondrial fission and neuronal apoptosis

(2018) Miao-Yu Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Recovery of Neurovascular Unit Integrity by CDK5-KD Astrocyte Transplantation in a Global Cerebral Ischemia Model

(2018) Andrea Becerra-Calixto et al.   MOLECULAR NEUROBIOLOGY

CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways

(2018) Chinthasagar Bastian et al.   NEUROBIOLOGY OF DISEASE

A Nestin-Cyclin-Dependent Kinase 5-Dynamin-Related Protein 1 Axis Regulates Neural Stem/Progenitor Cell Stemness via a Metabolic Shift

(2018) Jiancheng Wang et al.   STEM CELLS

Diverse roles of mitochondria in ischemic stroke

(2018) Jenq-Lin Yang et al.   Redox Biology

Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats

(2018) Lixuan Zhan et al.   FASEB JOURNAL

Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke

(2018) Qing-Zhang Tuo et al.   Cell Death & Disease

CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus

(2017) Hye-Won Hyun et al.   NEUROSCIENCE RESEARCH

p47Phox/CDK5/DRP1-Mediated Mitochondrial Fission Evokes PV Cell Degeneration in the Rat Dentate Gyrus Following Status Epilepticus

(2017) Ji-Eun Kim et al.   Frontiers in Cellular Neuroscience

Neuroprotective Mechanisms Mediated by CDK5 Inhibition

(2016) Gohar Mushtaq et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotection Induced by Transplanted CDK5 Knockdown Astrocytes in Global Cerebral Ischemic Rats

(2016) Andrea Becerra-Calixto et al.   MOLECULAR NEUROBIOLOGY

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease

(2015) Marta Cherubini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A novel phosphorylation site of N-methyl- d -aspartate receptor GluN2B at S1284 is regulated by Cdk5 in neuronal ischemia

(2015) Wen Lu et al.   EXPERIMENTAL NEUROLOGY

CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

(2015) Arezu Jahani-Asl et al.   HUMAN MOLECULAR GENETICS

CDK5 Knockdown Prevents Hippocampal Degeneration and Cognitive Dysfunction Produced by Cerebral Ischemia

(2015) Johana A Gutiérrez-Vargas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation

(2014) Anton Kichev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation

(2010) Ya-Li Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

Essential Role of Cytoplasmic cdk5 and Prx2 in Multiple Ischemic Injury Models, In Vivo

(2009) J. Rashidian et al.   JOURNAL OF NEUROSCIENCE