Journal
RSC ADVANCES
Volume 7, Issue 28, Pages 17514-17518Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra26427a
Keywords
-
Categories
Funding
- young scholar scientific and technological innovative research team in Sichuan province [2014TD0021]
- provincial universities innovative research team in Sichuan province [2014TD0023]
Ask authors/readers for more resources
Melittin is a 26-residue, amphipathic, cell-penetrating, alpha-helical anti-hepatoma peptide isolated from bee venom. However, the application of melittin as a drug is limited owing to its original conformational flexibility and low stability. In this study, we designed, synthesized, and tested a series of hydrocarbon-stapled analogs of melittin, of which, some analogs showed remarkable enhancement not only in anti-hepatoma activity, but also in alpha-helicity and protease resistance when compared to the parent melittin. These results disclosed the important impact of all-hydrocarbon crosslinking on the biological activity, stability, and hemolytic activity of melittin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available