Article
Biochemistry & Molecular Biology
Ahmed Abd El-Fattah, Elizabeth Grillo Fernandes, Federica Chiellini, Emo Chiellini
Summary: Amphiphilic copolymers with interesting architecture and tunable properties are promising materials for biomedical applications. Enzymatic catalysis provides a suitable alternative for the preparation of these materials without the use of toxic catalysts. The structure-property relationship of copolymers was studied by varying the molecular weight of Pluronic (EPE) and the molar ratios between ε-caprolactone monomer and EPE macro-initiator (M/In). The obtained copolymers were chemically characterized and their morphologies evaluated. The results showed a correlation between the differential scanning calorimetry data and X-ray diffraction data, suggesting the importance of the central block length in crystal formation. Preliminary cytotoxicity experiments confirmed the non-toxic nature of the copolymers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Renata Calegari Lino, Sabrina Matos de Carvalho, Carolina Montanheiro Noronha, William Gustavo Sganzerla, Cleonice Goncalves da Rosa, Michael Ramos Nunes, Roseane Farias D'Avila, Rui Carlos Zambiazi, Pedro Luiz Manique Barreto
Summary: This study produced methylcellulose films functionalized with poly-epsilon-caprolactone nanocapsules entrapped beta-carotene, which showed improved antioxidant activity and reduced light transmission. The release of beta-carotene from the films reached a desired value for food application. The functionalized films have the potential to be a novel nanomaterial for food conservation, increasing the shelf life of perishable food products.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Erveton Pinheiro Pinto, Sarah Olivia Alves Mendes da Costa, Cecile D'Haese, Bernard Nysten, Francisco Paiva Machado, Leandro Machado Rocha, Tiago Marcolino de Souza, Ana Beloqui, Renes Resende Machado, Raquel Silva Araujo
Summary: This study aimed to encapsulate copaiba essential oil (CO) in polymeric nanocapsules and evaluate their effect on inflammation and pain. The results showed that CO-NC exhibited anti-inflammatory and antioxidant effects, and reduced mechanical allodynia and paw edema induced by inflammation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Environmental Sciences
Ives Charlie-Silva, Natalia Martins Feitosa, Hirla Costa Silva Fukushima, Ricardo Carneiro Borra, Mary Ann Foglio, Rogeria Maura Pazini Xavier, Daniela Chemin de Melo Hoyos, Ilza Maria de Oliveira Sousa, Giovane Galdino de Souza, Ricardo Lacava Bailone, Marco Antonio de Andrade Belo, Sostenes Apolo Marcelino Correia, Jose Dias Correa Junior, Felipe Pierezan, Guilherme Malafaia
Summary: The study highlights the toxic effects of combining artemisinin with polymeric nanoparticles on zebrafish embryos and adults, showing increased coagulation and pericarditis, respectively. These findings suggest potential ecotoxicological concerns regarding the therapeutic use of such combination.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Monika Hofbauerova, Magdalena Ruskova, Andrea Puskarova, Maria Buckova, Adriana Annusova, Eva Majkova, Peter Siffalovic, Giuseppe Granata, Edoardo Napoli, Corrada Geraci, Domenico Pangallo
Summary: The colonization of building materials by microorganisms is a major cause of degradation, posing health risks from fungal and bacterial products. The study evaluated the efficacy of oregano and thyme essential oils encapsulated in nanocapsules for protection and disinfection against various microorganisms. The results showed that these nanocapsules effectively disinfect and inhibit biofilm formation without causing visible color changes in the materials.
Article
Pharmacology & Pharmacy
Lijun Xu, Ziqiang Zhou, Yuying Chen, Huangjie Lu, Ping Hu
Summary: This study developed a hyaluronic-acid-based hydrogel for treating complex burn wounds, which successfully encapsulated Resina Draconis particles for sustained release of active components. The hydrogel demonstrated good biocompatibility, enhanced cell migration, inhibited inflammatory cytokine production, induced rapid hemostasis, promoted collagen regeneration and accelerated wound recovery in animal models.
Article
Pharmacology & Pharmacy
Magdalena Kapustova, Andrea Puskarova, Maria Buckova, Giuseppe Granata, Edoardo Napoli, Adriana Annusova, Monika Mesarosova, Katarina Kozics, Domenico Pangallo, Corrada Geraci
Summary: This study demonstrates the effectiveness of poly(epsilon-caprolactone) nanocapsules loaded with thyme and oregano essential oils in reducing microbial and biofilm growth without cytotoxicity on human keratinocyte cells, as well as the absence of DNA damage induction.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Guilherme dos Anjos Camargo, Leandro Ferreira, Diego Jose Schebelski, Amanda Martinez Lyra, Fernanda Malaquias Barboza, Bruna Carletto, Adriana Yuriko Koga, Betina Christi Semianko, Daniele Toniolo Dias, Leandro Cavalcante Lipinski, Andressa Novatski, Vijayasankar Raman, Jane Manfron, Jessica Mendes Nadal, Paulo Vitor Farago
Summary: The study demonstrated the successful use of TAC-loaded nanocapsules for controlling atopic dermatitis. The nanocapsules exhibited good biostability and drug release efficacy in experiments. This research provides a new perspective for finding treatment options to reduce drug side effects and enhance bioavailability.
Article
Engineering, Biomedical
Ghazal Bayat, Mahshid Fallah-Darrehchi, Payam Zahedi, Abdolmajid Bayandori Moghadam, Pejman Ghaffari-Bohlouli, Hafez Jafari
Summary: This study prepared a biologically active wound dressing based on electrospun poly(e-caprolactone)/cellulose acetate blend nanofibers incorporated with kiwi extract, which showed positive effects in promoting burn wound healing.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Materials Science, Biomaterials
Jiawen Peng, Shuang Xie, Kun Huang, Pan Ran, Junwu Wei, Zhanlin Zhang, Xiaohong Li
Summary: This study proposes the use of self-propelled nanomotors to enhance biofilm infiltration, bacterial destruction, and endotoxin clearance, thereby accelerating the healing of infected burn wounds. The nanomotors release nitric oxide to destroy bacteria and bind with the bacteria to remove endotoxins. Animal experiments showed that the infected wounds were completely healed and exhibited skin features similar to normal skin after treatment with the nanomotors.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Critical Care Medicine
Shahd Nour, Gavin Reid, Kugili Sathanantham, Ian Mackie
Summary: The study surveyed the use of antimicrobial dressings for treating local pseudomonas wound infections in UK burns services, revealing significant variations in the choice of antimicrobial agents among different institutions. Further research is needed to establish national guidelines based on evidence-based practices.
Article
Medicine, Research & Experimental
Avleen Kour, Sundeep Jaglan, Sarika Sharma, Sandeep Sharma
Summary: Burn insults cause intense damage to the skin and tissues, impairing the immune system and wound healing process. The most common infection-causing bacteria is Pseudomonas aeruginosa, which thrives in moist environments. Rising drug resistance has rendered conventional treatments ineffective. Thus, research is needed to develop an antimicrobial therapy targeting P. aeruginosa infection, immunomodulation, and wound healing.
MEDICAL HYPOTHESES
(2023)
Article
Pharmacology & Pharmacy
Noor Ullah, Dildar Khan, Naveed Ahmed, Amna Zafar, Kifayat Ullah Shah, Asim ur Rehman
Summary: The study developed a lipase-sensitive nanoparticles-based hydrogel for topical delivery of fusidic acid (FA) against wound infection. The optimized formulation had a particle size of approximately 225 nm and zeta potential-16 mV with an entrapment efficiency of 87%. Incorporation of FA nanoparticles (FA-NPs) in carbopol hydrogel resulted in a 2-4-fold increase in antibacterial activity compared to FA solution and marketed cream. In vitro and in vivo studies showed site-specific delivery of FA and improved healing of wounds with the FA-NPs hydrogel formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohaddeseh Sharifi, S. Ameneh Sadati, S. Hajir Bahrami, S. Mohammad Amin Haramshahi
Summary: Electrospun fibrous scaffolds have great potential for wound treatment. Novel blend scaffolds were fabricated using poly(epsilon-caprolactone) (PCL)/poly(lactic acid) (PLA) with Nigella sativa (NS) extract. RSM and ANN models were used to determine optimal nanofiber structures. The results showed that high concentrations of NS extract affected the properties of the nanofibers. The PLA/PCL/NS 25% nanofiber scaffold exhibited the best performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Juliana Parente Menezes Ribeiro, Diego Jose Schebelski, Amanda Martinez Lyra, Guilherme dos Anjos Camargo, Jessica Mendes Nadal, Andressa Novatski, Jane Manfron, Paulo Vitor Farago
Summary: Hydroxytyrosol (HT) was loaded into poly(epsilon-caprolactone) nanocapsules for its potential use in pharmaceutical and nutraceutical products. The nanocapsules were successfully prepared and characterized, demonstrating high drug encapsulation efficiency. However, the formulations showed stability changes within 30 to 90 days.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2023)
Article
Immunology
Raghuram Kandimalla, Farrukh Aqil, Neha Tyagi, Ramesh Gupta
Summary: Exosomes are biogenic nanocarriers of endocytic origin found in biofluids like milk, with milk exosomes being a particularly promising source for drug delivery. They are being increasingly explored for delivering both small drug molecules and siRNA to combat cancer, thanks to their biocompatibility and unique properties. Various isolation techniques, physicochemical properties, biodistribution, and applications of milk exosomes in drug delivery were highlighted in this article.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Oncology
Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Raghuram Kandimalla, Margaret Wallen, Neha Tyagi, Sarah Wilcher, Jun Yan, David J. Schultz, Wendy Spencer, Ramesh C. Gupta
Summary: The use of bovine colostrum exosomes and polyethyleneimine matrix for gene delivery shows promise in targeting KRAS and WT p53 for effective gene therapy, representing a novel platform for therapeutic nucleic acids delivery to treat human disease.
Article
Oncology
Mohd Saeed, Ambreen Shoaib, Raghuram Kandimalla, Shamama Javed, Ahmad Almatroudi, Ramesh Gupta, Farrukh Aqil
Summary: This review highlights the important role of gut microbiota in the pathogenesis of colorectal cancer (CRC) and discusses strategies involving the use of microorganisms to prevent and treat CRC.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Suman Sarkar, Ashim Chandra Bhowal, Raghuram Kandimalla, Sarathi Kundu
Summary: Negatively charged gold and silver nanoparticles were prepared using the dry leaf of Annona reticulata and utilized to fabricate thin films of PEDOT:PSS nanocomposites. The type and concentration of nanoparticles were found to result in significant changes in the structure, morphology, and electrical behaviors of the nanocomposite thin films. Increasing nanoparticle concentration moderately enhanced the in-plane DC conductivity of the composite films, while impedance spectroscopy revealed variations in impedance as a function of nanoparticles concentration and applied frequency.
Article
Chemistry, Medicinal
Sagar Barge, Barsha Deka, Bhaswati Kashyap, Simanta Bharadwaj, Raghuram Kandimalla, Aparajita Ghosh, Partha Pratim Dutta, Suman Kumar Samanta, Prasenjit Manna, Jagat C. Borah, Narayan Chandra Talukdar
Summary: This study investigated the potential anti-obesity effects of Lysimachia candida and its phytochemical astragalin, which were found to decrease body weight gain and blood lipid levels, as well as reduce the expression of adipogenic transcription factors. The compounds exhibited antiadipogenic activity both in vivo and in vitro, suggesting their potential for clinical use in managing obesity.
PHYTOTHERAPY RESEARCH
(2021)
Editorial Material
Pharmacology & Pharmacy
Jamal M. Arif, Raghuram Kandimalla, Farrukh Aqil
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Margaret Wallen, Farrukh Aqil, Raghuram Kandimalla, Jeyaprakash Jeyabalan, Supipi Auwardt, Neha Tyagi, David J. Schultz, Wendy Spencer, Ramesh C. Gupta
Summary: To overcome strict biosafety containment and rapid gene mutation, researchers have developed a nanoparticle delivery system called EPM, using colostrum exosomes as carriers, to mimic viral protein expression in emerging viral diseases. This system can expand the number of laboratories actively participating in the screening of potential therapeutics and has the ability to simulate viral gene expression and screen antiviral siRNA therapies.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Microbiology
Priyanka Sarkar, Raghuram Kandimalla, Anupam Bhattacharya, Romi Wahengbam, Madhusmita Dehingia, Mohan Chandra Kalita, Narayan Chandra Talukdar, Rupjyoti Talukdar, Mojibur R. Khan
Summary: This study investigates the potential impact of non-ethanolic ingredients in whisky on the gut bacteriome. The results show that these non-ethanolic components have an impact on the gut microbiome and metabolites. The study emphasizes the importance of studying the impact of non-ethanolic ingredients in alcoholic beverages on host health.
Article
Oncology
Disha N. Moholkar, Raghuram Kandimalla, Ramesh C. Gupta, Farrukh Aqil
Summary: Cancer has surpassed heart disease as the leading cause of deaths for the age group 45-65, prompting increased research on innovative nano formulations for cancer therapy. Lipid-based carriers, such as liposomes and exosomes, have been extensively studied. Recently, researchers have developed hybrid exosomes by fusing liposomes and exosomes, which may offer advantages such as high drug loading, targeted cellular uptake, and biocompatibility.
Meeting Abstract
Oncology
Disha Nagesh Moholkar, Raghuram Kandimalla, Farrukh Aqil, Ramesh Gupta
Meeting Abstract
Oncology
Raghuram Kandimalla, Farrukh Aqil, Disha N. Moholkar, Suman K. Samanta, Ramesh C. Gupta
Meeting Abstract
Oncology
Raghuram Kandimalla, Disha N. Moholkar, Jayaprakash Jeyabalan, Wendy Spencer, Ramesh C. Gupta, Farrukh Aqil
Meeting Abstract
Oncology
Farrukh Aqil, Raghuram Kandimalla, Neha Tyagi, Mohd Saeed, Ramesh Gupta
Proceedings Paper
Materials Science, Multidisciplinary
Jejiron Maheswari Baruah, Jyoti Narayan, Sanjeeb Kalita, Raghuram Kandimalla
Summary: Zinc Selenide Quantum Dots (QDs) synthesized using green chemistry principles exhibit excellent luminescence properties and high antibacterial efficacy while maintaining biocompatibility with mouse and human red blood cells.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Raghuram Kandimalla, Momita Das, Swarnali Bhattacharjee, Paramita Choudhury, Rajlakshmi Devi, Narayan C. Talukdar, Suman Kumar Samanta
Summary: The study showed that mice treated with the highest doses of MNU were significantly less efficient in getting pregnant compared to the control group, while changes in body weight, food, and water intake were noted in mice exposed to MNU. Furthermore, a significant increase in the cumulative weight of vital female organs like uterus and ovary was observed in mice injected with quadruple doses of MNU compared to control mice.