Article
Food Science & Technology
Chia-Chien Hsieh, Yen-Fang Wang, Pin-Yu Lin, Shih-Han Peng, Mei-Jia Chou
Summary: The study revealed that lunasin can reduce inflammation levels in obese mice, decrease macrophage infiltration in adipose tissue, and regulate spleen size and cell numbers. Additionally, lunasin promotes the production of interferon gamma and interleukin-2 in splenocytes, thus modulating immune responses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Immunology
Huiming Tang, Shuang Qin, Zhanfei Li, Wei Gao, Manli Tang, Xijie Dong
Summary: This study investigates the early immune system changes in patients with septic shock. A total of 243 patients were included, classified as survivors or nonsurvivors. Tests were performed to examine immune system function. Neutrophil counts, infection biomarkers, and cytokines increased significantly in septic shock patients, while lymphocyte counts, immunoglobulin levels, and complement protein levels decreased. Nonsurvivors had higher levels of certain cytokines but lower levels of immunoglobulins and lymphocyte counts. Low immunoglobulin or complement concentrations and low lymphocyte or CD4+ T cell counts were independent risk factors for mortality.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Aurelien Frerou, Mathieu Lesouhaitier, Murielle Gregoire, Fabrice Uhel, Arnaud Gacouin, Florian Reizine, Caroline Moreau, Aurelie Loirat, Adel Maamar, Nicolas Nesseler, Amedeo Anselmi, Erwan Flecher, Jean-Philippe Verhoye, Yves Le Tulzo, Michel Cogne, Mikael Roussel, Karin Tarte, Jean-Marc Tadie
Summary: This study revealed that the initiation of VA-ECMO leads to early immune alterations, including increased circulating immature neutrophils, decreased C5a receptor expression, lymphocyte dysfunction, and expansion of myeloid-derived suppressor cells (MDSC). ELISA analysis further showed an increase in pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha, along with the highly immunosuppressive cytokine IL-10, following VA-ECMO initiation. These findings suggest that VA-ECMO may cause immune changes that increase the risk of infection.
Article
Biochemistry & Molecular Biology
Xiuting Yao, Chenxi Yang, Conghui Wang, Hong Li, Jingyi Zhao, Xiaomin Kang, Zhuodong Liu, Lingyan Chen, Xinyu Chen, Tianshu Pu, Qinyang Li, Lijie Liu
Summary: Adolescence is a critical period for brain development, and high-fat diet consumption can negatively affect emotional health. This study found that high-fat diet in adolescence led to increased depression and anxiety, decreased neurogenesis in the hippocampus, and excessive microglial activation. Additionally, abnormal microglial engulfment of newborn neurons was observed in the high-fat diet group. These findings contribute to our understanding of the mechanisms underlying high-fat diet-related affective disorders in young people.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qihui Luo, Asad Jahangir, Junbo He, Chao Huang, Yu Xia, Lanlan Jia, Xiaoli Wei, Ting Pan, Yanni Du, Bin Mu, Huan Gong, Wentao Liu, Saif Ur-Rehman, Kangcheng Pan, Zhengli Chen
Summary: This study investigated the protective effects of TRIM67 in the intestine of obese mice and showed for the first time that HFD and TRIM67 KO have synergistic damaging effects on the intestine, while TRIM67 plays an important protective role in HFD-induced intestinal damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hong Zhuang, Xiuting Yao, Hong Li, Qian Li, Chenxi Yang, Conghui Wang, Dan Xu, Yu Xiao, Yuan Gao, Jiayi Gao, Mingze Bi, Rui Liu, Gaojun Teng, Lijie Liu
Summary: Chronic consumption of a high-fat diet from young adulthood to middle age induces anxiety and depression-like symptoms, as well as memory impairment. The negative effects on behavior and hippocampal neuroplasticity seem to be linked to changes in microglial phenotype accompanied by increased cellular lipid accumulation.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Conghui Wang, Hong Li, Chen Chen, Xiuting Yao, Chenxi Yang, Zhehao Yu, Jiayi Ren, Yue Ming, Yi Huang, Yi Rong, Yu Ma, Lijie Liu
Summary: The association between a high-fat diet consumption and emotional/cognitive disorders is well-documented. The prefrontal cortex, a brain region responsible for emotion and cognition, undergoes protracted maturation during adolescence and is highly vulnerable to environmental factors. A study on adolescent mice fed a high-fat diet found that it led to anxiety- and depression-like behavior, as well as abnormalities in the prefrontal cortex structure, suggesting a link between high-fat diet and mood disorders in adolescents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Jia Sun, Luo Chen, Xiao-Ao Xiao, Mo-Qiu Jia, Xin-Yuan Wang, Han Jiao, Yuanqing Gao
Summary: The study revealed that a high-fat diet affects intestinal ACE2 protein levels in adults and neonates differently, suggesting a potential role of macrophages in SARS-CoV-2 intestinal infection.
Article
Cardiac & Cardiovascular Systems
Satya Murthy Tadinada, Eric T. Weatherford, Greg Collins, Gourav Bhardwaj, Jesse Cochran, William Kutschke, Kathy Zimmerman, Alyssa Bosko, Brian T. O'Neill, Robert M. Weiss, E. Dale Abel
Summary: The study found that despite inducing cardiac hypertrophy and increasing cardiac fatty acid metabolism, long-term fat feeding in mice may not be enough to activate pathological hypertrophic mechanisms that impair cardiac function or induce cardiac fibrosis. Additionally, unknown factors may contribute to the cardiac abnormalities reported by many research groups.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biology
Valentina Murtaj, Silvia Penati, Sara Belloli, Maria Foti, Angela Coliva, Angela Papagna, Cecilia Gotti, Elisa Toninelli, Remy Chiaffarelli, Stefano Mantero, Susanna Pucci, Michela Matteoli, Maria Luisa Malosio, Rosa Maria Moresco
Summary: The study found that male mice exposed to a high fat diet are more susceptible to metabolic changes compared to female mice, showing faster and higher weight gain, elevated cholesterol and liver enzyme levels, and more prominent brain inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Ophthalmology
Jinghua Bu, Minjie Zhang, Yang Wu, Nan Jiang, Yuli Guo, Xin He, Hui He, M. Vimalin Jeyalatha, Peter Sol Reinach, Zuguo Liu, Wei Li
Summary: High-fat diet-induced declines in PPAR-gamma expression and activation of MAPK and NF-kappa B signaling pathways may lead to meibomian gland inflammation and dysfunction in mice, characterized by lipid accumulation, inflammatory cell infiltration, apoptosis, and mitochondria damage. Treatment involving dietary shifts and medication administration can alleviate this inflammation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Sophie B. Chehade, George B. H. Green, Christopher D. Graham, Ayanabha Chakraborti, Bijal Vashai, Amber Moon, Michael B. Williams, Benjamin Vickers, Taylor Berryhill, William van der Pol, Landon Wilson, Mickie L. Powell, Daniel L. Smith, Stephen Barnes, Casey Morrow, M. Shahid Mukhtar, Gregory D. Kennedy, James A. Bibb, Stephen A. Watts
Summary: Investigations have shown that western dietary patterns play a causative role in obesity and disease pathogenesis, and the quality and quantity of dietary fats and carbohydrates can predict the development of these disorders. Traditional rodent diets do not reflect modern human dietary habits, and high-fat diets used in previous studies did not accurately represent human fat intake levels. Recent research focuses on developing pre-clinical diets that resemble human diets. This study emphasizes the importance of diet quality in maintaining metabolic homeostasis and highlights the need for relevant pre-clinical diets to study chronic diseases affected by western dietary consumption patterns.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Qiming Ma, Li Wen, Yanxia Tian, Liqin Ma, Zhangsheng Wen, Yang Kun, Mengping Xu, Xiaoping Liu
Summary: This study found that Sulfosuccinimidyl oleate (SSO) can effectively treat obesity and metabolic syndrome induced by a high-fat diet. By inhibiting the absorption of intestinal fatty acids, SSO reduces plasma levels of triglycerides and free fatty acids, and alleviates fatty liver induced by obesity. Additionally, SSO improves blood glucose and insulin resistance.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shaoxiong Huang, Shiliang Dong, Lizhen Lin, Qiming Ma, Mengping Xu, Limei Ni, Qitong Fan
Summary: Inulin, a natural plant extract, improves metabolic syndrome by modulating the gut microbiota and inducing bile acid excretion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Mohammed Abdo Yahya, Ghedeir M. Alshammari, Magdi A. Osman, Laila Naif Al-Harbi, Abu El Gasim A. Yagoub, Sahar Abdulaziz Al Sedairy
Summary: Isoliquiritigenin (ISL) can attenuate high-fat diet-induced intestinal damage and inflammation by modulating Nrf2. It improves the structure of the duodenum, reduces oxidative stress and inflammation, and enhances antioxidant enzyme activity to strengthen the intestinal barrier.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemical Research Methods
Oscar Gerardo Silva-Gaona, Juan Manuel Guzman-Flores, Magdalena Hernandez-Ortiz, Katya Vargas-Ortiz, Joel Ramirez-Emiliano, Sergio Encarnacion-Guevara, Victoriano Perez-Vazquez
Summary: The study found that curcumin can reverse the expression changes of seven proteins in the liver of diabetic mice, which are involved in the metabolism of amino acids, carbohydrates, and lipids.
CURRENT PROTEOMICS
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Jose Hernandez-Granados, Rosa Isela Ortiz-Basurto, Maribel Jimenez-Fernandez, Carlos Alberto Garcia-Munguia, Elena Franco-Robles
Summary: This study evaluated the effects of dietary supplementation with Bifidobacterium animalis, Agave fructans, and a symbiotic of both on broiler chickens, comparing with diets including antibiotic growth promoters and without additives. The results showed that alternative treatments achieved similar productive results as growth-promoting antibiotics, with improved immune status and gastrointestinal tract development.
Article
Pharmacology & Pharmacy
Maria Cristina Leon-Garcia, Oscar Gerardo Silva-Gaona, Magdalena Hernandez-Ortiz, Katya Vargas-Ortiz, Joel Ramirez-Emiliano, Ma Eugenia Garay-Sevilla, Sergio Encarnacion-Guevara, Victoriano Perez-Vazquez
Summary: The study demonstrated that curcumin could reduce the glycation levels of specific proteins in the hearts of mice fed with a high fructose diet, which are involved in various biological processes such as cellular respiration and oxidative phosphorylation.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Food Science & Technology
Cesar Ozuna, Elena Franco-Robles
Summary: This critical review provides an overview of recent scientific research regarding the applications of agave syrup in the food industry and its effects on consumer health. While agave syrup contains some natural compounds with potential health benefits, its high fructose concentration can have serious adverse effects on human health. Therefore, there is a need to find ways to reduce the health risks and adverse effects of fructose intake while maintaining its technological properties for food product development.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Oscar Gerardo Silva-Gaona, Magdalena Hernandaz-Ortiz, Katya Vargas-Ortiz, Joel Ramirez-Emiliano, Ma. Eugenia Garay-Sevilla, Sergio Encarnacion-Guevara, Victoriano Perez-Vazquez
Summary: Increased fructose consumption is associated with metabolic diseases. Curcumin, a natural compound, can regulate protein expression and metabolic pathways. This study found that the expression of 113 proteins changed in the livers of mice fed fructose, and curcumin modified the expression of 64 proteins in mice fed fructose and curcumin. Curcumin can prevent some protein expression changes induced by fructose consumption.
JOURNAL OF PROTEOMICS
(2022)
Review
Pharmacology & Pharmacy
Cecilia Gabriela Melendez-Salcido, Joel Ramirez-Emiliano, Victoriano Perez-Vazquez
Summary: Poor dietary habits, such as consuming high-fructose and high-fat diets, are associated with the development of metabolic abnormalities and conditions like obesity, diabetes, and dyslipidemia. The kidneys are particularly vulnerable to dyslipidemia, which can lead to lipid accumulation and impaired kidney function.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Physiology
Sandra G. Parada-Sanchez, Maciste H. Macias-Cervantes, Victoriano Perez-Vazquez, Katya Vargas-Ortiz
Summary: This article reviewed the literature and evaluated the effects of different types of training on circulating irisin levels in healthy subjects and those with different metabolic conditions. The results showed that various types of training can increase circulating irisin levels, with consistently maintained moderate to high intensity training showing better effectiveness. However, the increase in circulating irisin levels depends on the subject's metabolic condition and age.
PHYSIOLOGICAL RESEARCH
(2022)
Article
Veterinary Sciences
Jaquelina Julia Guzman-Rodriguez, Abner Josue Gutierrez-Chavez, Rosa M. Melendez-Soto, Marco Antonio Amador-Sanchez, Elena Franco-Robles
Summary: The study investigated the effects of Agave fructans (AF) on multi-resistant and biofilm-forming isolates of Staphylococcus aureus. The results showed that AF inhibited the growth rate and biofilm formation of S. aureus, suggesting its potential therapeutic efficacy for bovine mastitis.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Chemical
Elizabeth Nieto-Mazzocco, Elena Franco-Robles, Adriana Saldana-Robles, Neith Pacheco, Cesar Ozuna
Summary: The purpose of this study was to evaluate the effect of thermal treatment on the composition of commercial sweeteners and metabolic responses in mice. The results showed changes in the concentration of simple sugars after thermal treatment. Importantly, thermal treatment modulated metabolic responses in all sweeteners, leading to increased food and beverage intake, weight gain, energy, glucose levels, GLP-1 and insulin release, and the generation of protein carbonyl and malondialdehyde.
Article
Biochemistry & Molecular Biology
Juan Manuel Guzman-Flores, Victoriano Perez-Vazquez, Fernando Martinez-Esquivias, Mario Alberto Isiordia-Espinoza, Juan Manuel Viveros-Paredes
Summary: This study explored the pharmacological mechanism of C. sativa in treating type 2 diabetes (T2D) and found that it exerts anti-diabetic effects through the insulin signaling pathway, with the participation of HIF-1 and FoxO.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Food Science & Technology
Elizabeth Nieto-Mazzocco, Adriana Saldana-Robles, Elena Franco-Robles, Ana Isabel Mireles-Arriaga, Everardo Mares-Mares, Cesar Ozuna
Summary: This study optimized the use of agavin-type fructans (ATF) as fat and sucrose replacers in gluten-free muffin formulation, resulting in reduced sucrose and fat content. The muffins with ATF replacements showed some differences in texture, color, and cell structure compared to the control, but were not noticed by the sensory panel. The chemical composition analysis revealed reduced carbohydrate and fat content in the ATF products. Overall, ATF has proven to be a potential functional ingredient for the development of low-fat and low-sucrose gluten-free bakery products.
