Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example

Strategies that Target Tight Junctions for Enhanced Drug Delivery

(2016) Lorenza González-Mariscal et al.   CURRENT PHARMACEUTICAL DESIGN

Research progress on berberine with a special focus on its oral bioavailability

(2016) Chang-Shun Liu et al.   FITOTERAPIA

Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine

(2015) Chen Chen et al.   XENOBIOTICA

Downregulation of Cellular c-Jun N-Terminal Protein Kinase and NF-κB Activation by Berberine May Result in Inhibition of Herpes Simplex Virus Replication

(2014) Siwei Song et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Berberine attenuates autophagy in adipocytes by targeting BECN1

(2014) Yujie Deng et al.   Autophagy

Alkaloids in the Nature: Pharmacological Applications in Clinical Practice of Berberine and Mate Tea

(2014) Giuseppe Derosa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Berberine and Its Metabolites: Relationship between Physicochemical Properties and Plasma Levels after Administration to Human Subjects

(2014) Silvia Spinozzi et al.   JOURNAL OF NATURAL PRODUCTS

Berberine Induces Senescence of Human Glioblastoma Cells by Downregulating the EGFR-MEK-ERK Signaling Pathway

(2014) Q. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Biopharmaceutical Profiling of New Antitumor Pyrazole Derivatives

(2014) Valentina Anuta et al.   MOLECULES

Effects of berberine and red yeast on proinflammatory cytokines IL-6 and TNF-α in peripheral blood mononuclear cells (PBMCs) of human subjects

(2014) Carmen Spatuzza et al.   Frontiers in Pharmacology

Liquid chromatography/tandem mass spectrometry method for quantitative estimation of polyethylene glycol 400 and its applications

(2013) V. Vijaya Bhaskar et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Improvement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying technique

(2013) Swati Pund et al.   PHYTOMEDICINE

Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption

(2013) S. Attili-Qadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs

(2012) Arik Dahan et al.   AAPS Journal

Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy

(2012) Gang Fan et al.   ANALYTICA CHIMICA ACTA

Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression

(2012) H.-L. Zhao et al.   DIABETES

Accounting for the solubility–permeability interplay in oral formulation development for poor water solubility drugs: The effect of PEG-400 on carbamazepine absorption

(2012) Avital Beig et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Pharmaceutical Excipients Influence the Function of Human Uptake Transporting Proteins

(2012) Anett Engel et al.   MOLECULAR PHARMACEUTICS

Agents that act luminally to treat diarrhoea and constipation

(2012) Stacy Menees et al.   Nature Reviews Gastroenterology & Hepatology

Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine

(2012) Thinnakorn Lao-ong et al.   PHARMACEUTICAL BIOLOGY

Intestinal lymphatic transport for drug delivery

(2011) Jaime A. Yáñez et al.   ADVANCED DRUG DELIVERY REVIEWS

Gastric mucosal changes induced by polyethylene glycol 400 administered by gavage in rats

(2011) Yoshihide Ueda et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats

(2011) Zhiwen Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

(2011) Weidong Xie et al.   PLoS One

Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein

(2011) Xinfeng Zhang et al.   XENOBIOTICA

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

(2010) Y.-T. Liu et al.   DRUG METABOLISM AND DISPOSITION

Berberine: a potential phytochemical with multispectrum therapeutic activities

(2010) Parameswara Rao Vuddanda et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism

(2010) Fang Gao et al.   JOURNAL OF CONTROLLED RELEASE

The effects of common solubilizing agents on the intestinal membrane barrier functions and membrane toxicity in rats

(2009) Khuriah Abdul Hamid et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Absorption Barriers in the Rat Intestinal Mucosa. 3: Effects of Polyethoxylated Solubilizing Agents on Drug Permeation and Metabolism

(2009) Daniel R. Mudra et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

(2008) Mária A. Deli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Drug permeability across a phospholipid vesicle-based barrier

(2008) Gøril Eide Flaten et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Polyethylene Glycol 400 Enhances the Bioavailability of a BCS Class III Drug (Ranitidine) in Male Subjects but Not Females

(2008) Diane A. I. Ashiru et al.   PHARMACEUTICAL RESEARCH