Article
Chemistry, Multidisciplinary
Jennifer Noro, Joana Cabo, David S. Freitas, Catarina S. Roque, Mariana de Castro, Artur Cavaco-Paulo, Carla Silva
Summary: In this study, three deep eutectic mixtures (DES) were used as mediums to synthesize glucose laurate and glucose acetate. Lipases from Aspergillus oryzae (LAO), Candida rugosa (LCR), and porcine pancreas (LPP) were employed as catalysts. The results showed that DES did not deactivate the lipases when used as medium. For transesterification reactions, combining LAO or LCR with DES 3 resulted in efficient production of glucose laurate, while LPP performed best in DES 2 for glucose acetate synthesis. Substituting vinyl laurate with vinyl acetate led to different behaviors, with LCR and LPP showing better catalytic activity in DES 1 for glucose acetate production. LAO had lower activity, with only around 40% product yield in DES 3. These findings highlight the potential of biocatalysis combined with greener solvents for the synthesis of differentiated sugar fatty acid esters.
Article
Chemistry, Multidisciplinary
Rebecca Hollenbach, Andre Delavault, Laura Gebhardt, Hannah Soergel, Claudia Muhle-Goll, Katrin Ochsenreither, Christoph Syldatk
Summary: In this study, the combination of biocatalysis and mechanochemistry was used to synthesize glycolipid surfactants, resulting in higher yields using unconventional dissolved reaction systems and bead mill apparatus.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Energy & Fuels
Yaojia He, Kai Li, Guangxu Bo, Jianhua Wang, Li Xu, Jinyong Yan, Min Yang, Yunjun Yan
Summary: This study investigates the effect of adding a deep eutectic solvent on the yield of biodiesel catalyzed by liquid lipase 2. The results show that the addition of the deep eutectic solvent can improve the yield of biodiesel and enhance the reusability of the enzyme.
Article
Chemistry, Applied
Debora Procopio, Xavier Marset, Gabriela Guillena, Maria Luisa Di Gioia, Diego J. Ramon
Summary: In this study, environmentally friendly deep eutectic solvents (DESs) were used for the first time as reaction media for efficient photocatalytic amide synthesis at room temperature. The method showed mild conditions, a broad substrate scope, high yields (& LE;99%), and tolerance to air and moisture. It also allowed for the recycling of the reaction medium and catalyst without significant decrease in yield for at least three consecutive cycles.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Energy & Fuels
Kapil Mamtani, Kaveh Shahbaz, Mohammed M. Farid
Summary: This study summarizes the application of deep eutectic solvents (DESs) in biodiesel production, including their roles as catalysts, cosolvents, and extracting solvents. The research shows that DESs demonstrate good performance and recyclability in all roles. More research is needed to explore the potential of deep eutectic solvents in the field of biodiesel production in the future.
Article
Chemistry, Physical
Aditi Prabhune, Ranjan Dey
Summary: Deep Eutectic Solvents (DESs) have emerged as potential alternatives to conventional solvents in many industrial applications due to their safety, greenness, ease of preparation and wide range of applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Multidisciplinary
Tao Zhang, Thomas Doert, Hui Wang, Suojiang Zhang, Michael Ruck
Summary: This review explores the application of ionic liquids and deep eutectic solvents in the synthesis of inorganic materials, covering various types of deep eutectic solvents and ionic liquids, as well as their chemical reactions. It also highlights the caution that needs to be taken regarding their chemical reactivity, and provides guidelines for their proper use.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Maninder Meenu, Vasudha Bansal, Sudha Rana, Nitya Sharma, Vinod Kumar, Vaishali Arora, Monika Garg
Summary: Anthocyanins are extracted using alternative solvents such as ionic liquids, deep eutectic solvents, and natural deep eutectic solvents, which are more environmentally friendly and efficient compared to conventional solvents. Acid-based deep eutectic solvents with 20-30% water content showed the highest anthocyanin extraction yield. Ultrasonic-assisted extraction was the most common and efficient method, and DES-based extracts exhibited the highest stability and antioxidant activity. Fruits and their by-products are the most commonly used samples, while cereal and legumes are less explored.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Analytical
Eman O. Osman, Amr M. Mahmoud, Sally S. El-Mosallamy, Hala B. El-Nassan
Summary: This study reported the first synthesis of 4H-pyran derivatives using electrochemical synthesis conditions and deep eutectic solvents in a one pot reaction. By optimizing the reaction conditions, high yields of pure pyran derivatives could be obtained in a short amount of time. The use of deep eutectic solvents also eliminated the need for a supporting electrolyte, improving the sustainability of the catalyst.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Lawrence Mzukisi Madikizela, Somandla Ncube, Philiswa Nosizo Nomngongo, Vusumzi Emmanuel Pakade
Summary: This study reviewed the roles and benefits of using deep eutectic solvents (DESs) in the synthesis of molecularly imprinted polymers (MIPs). DESs were found to improve the greenness of synthetic procedures, enhance adsorption capacity and selectivity, and increase the availability of important functional groups on the surface of MIPs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Dorota Skowronska, Katarzyna Wilpiszewska
Summary: This review describes the application of deep eutectic solvents (DESs) for dissolving starch, plasticizing it, and making other modifications. DES can be a good alternative to common starch plasticizers and ionic liquids, and the wide range of DES component combinations allows for materials with specific properties for different applications.
Article
Chemistry, Multidisciplinary
Henrik Palmelund, Jukka Rantanen, Korbinian Lobmann
Summary: Deep eutectic solvents (DESs) are composed of a hydrogen bond donor and acceptor, and the interactions between them significantly lower the melting point of the mixture. Despite having eutectic melting temperatures above room temperature, all investigated DESs were able to appear liquid at room temperature under ambient conditions due to low RH0.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Physical
Xiumin Liu, Mengchao Wang, Xue Zhang, Yue Sun, Wen Song, Ya Liu
Summary: The study investigated the correlation between the physicochemical properties of deep eutectic solvents (DESs) and the catalyzed synthesis activity of lipase N435. It found that different water content and temperature had an effect on esterification conversion rate and that there was a correlation between viscosity and surface tension with conversion rates. Mathematical models were effective in correlating DESs properties with catalyzed synthesis activity.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Hala B. El-Nassan, Sally S. El-Mosallamy, Amr M. Mahmoud
Summary: This study reports the unexpected formation of xanthene-1,8-diones during the attempted Biginelli reaction. The reaction was carried out using cyclohexanedione, thiourea, and different aldehydes under electrochemical conditions with ethanol or deep eutectic solvents, and Amberlyst-15 & REG; was used as a catalyst. The formation of the expected Biginelli reaction product, hexahydroquinazoline-5-one, was not observed under various reaction conditions, suggesting a different mechanistic pathway leading to xanthene-1,8-dione formation. The mechanism was elucidated through cyclic voltammetry.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Review
Chemistry, Physical
Olga Dlugosz
Summary: Natural deep eutectic solvents (NDESs) are a new type of green solvent widely used in various fields such as industry, medicine, and nanotechnology due to their simple preparation, environmental friendliness, biocompatibility, and multifunctionality. This review focuses on their applications in nanotechnology processes, specifically in obtaining functional nanomaterials through their physicochemical properties. The advantages of using NDESs in obtaining inorganic nanoparticles are highlighted, including reducing energy consumption and functionalizing nanoparticles in situ. The review also discusses recent advances and future directions in the development and applications of NDESs in nanotechnology.
Article
Chemistry, Multidisciplinary
Fanni Sebak, Peter Ecsedi, Wolfgang Bermel, Burkhard Luy, Laszlo Nyitray, Andrea Bodor
Summary: This study introduces two new NMR experiments to identify proline cis/trans isomers in proteins, detecting minor conformers present in 4-15%, and analyzes the impact of CK2 phosphorylation on the cis/trans-proline equilibrium. Statistical analysis indicates that the amino acid type also affects the distribution of cis/trans-proline.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Jannis A. Reich, Miriam Assmann, Kristin Hoelting, Paul Bubenheim, Juergen Kuballa, Andreas Liese
Summary: The importance of a compound that fights against influenza is self-evident during a pandemic. Continuous flow reactors in chemical industry are considered the next stepping stone for large scale production of these compounds. This study investigates the synthesis of N-acetylneuraminic acid in a continuous fixed-bed reactor using immobilized enzymes, and shows the potential of a high-pressure circular reactor for increasing reaction equilibrium conversion and yield.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Sebastian Ehni, Martin R. M. Koos, Tony Reinsperger, Jens D. Haller, David L. Goodwin, Burkhard Luy
Summary: This study presents a new method to improve refocusing performance by incorporating coupling evolution into pulse design. By optimizing the refocusing pulses, heteronuclear coherence transfer in delay pulse-delay-type sequences is achieved. Additionally, efficient J-compensated refocusing pulse sandwiches are optimized.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Multidisciplinary Sciences
Nane C. Kuznik, Valeria Solozobova, Irene I. Lee, Nicole Jung, Linxiao Yang, Karin Nienhaus, Emmanuel A. Ntim, Jaice T. Rottenberg, Claudia Muhle-Goll, Amrish Rajendra Kumar, Ravindra Peravali, Simone Graessle, Victor Gourain, Celia Deville, Laura Cato, Antje Neeb, Marco Dilger, Christina A. Cramer von Clausbruch, Carsten Weiss, Bruno Kieffer, G. Ulrich Nienhaus, Myles Brown, Stefan Braese, Andrew C. B. Cato
Summary: BAG1 proteins, particularly the isoform BAG1L, play crucial roles in prostate cancer by regulating the androgen receptor (AR) and affecting gene expression related to oxidative stress and metabolism. A small molecule, A4B17, targeting the BAG domain, shows promising results in downregulating AR target genes and inhibiting prostate tumor development, outperforming the clinically approved antagonist enzalutamide. BAG1 inhibitors offer unique opportunities for antagonizing AR action and prostate cancer growth.
Article
Biochemistry & Molecular Biology
Verena Siebert, Mara Silber, Elena Heuten, Claudia Muhle-Goll, Marius K. Lemberg
Summary: The intramembrane protease PARL plays a crucial role in mitochondrial protection by cleaving the mitophagy regulators PINK1 and PGAM5. The cleavage of PGAM5 is influenced by multiple hierarchical substrate features, including a membrane potential-dependent oligomeric switch.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Stella Slad, Wolfgang Bermel, Rainer Kummerle, Daniel Mathieu, Burkhard Luy
Summary: Biomolecular NMR spectroscopy requires high magnetic field strengths for high spectral resolution. This study presents band-selective universal rotation pulses with a higher ratio of selective bandwidth to maximum rf-amplitude, which perform better than standard pulses according to simulations.
JOURNAL OF BIOMOLECULAR NMR
(2022)
Article
Biochemistry & Molecular Biology
Jens D. Haller, Andrea Bodor, Burkhard Luy
Summary: We present a real-time pure shift acquisition scheme for the detection of amide protons, which can effectively suppress the full homo- and heteronuclear coupling network, leading to improved resolution and sensitivity.
JOURNAL OF BIOMOLECULAR NMR
(2022)
Article
Chemistry, Physical
Benjamin Thomas, Daniel Ohde, Simon Matthes, Paul Bubenheim, Koichi Terasaka, Michael Schlueter, Andreas Liese
Summary: During the optimization of biocatalysis processes, it is important to overcome the limitations of mass transfer and enzyme stability. Aeration with microbubbles is advantageous due to its high gas utility, low-pressure drop, and reduced foam formation. This study compares the effects of microbubble, classic sub-millibubble, and macrobubble aeration on enzyme stability and gas utility.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Desiree Steuernagel, David Rombach, Daniel Sack, Martin Koos, Burkhard Luy, Hans-Achim Wagenknecht
Summary: A new method was developed to activate CCl3F using photoredox catalysis and functionalize alkenes with the CCl2F group. N-phenylphenothiazine was used as a highly reducing organophotocatalyst. This approach combines the efficient disposal of ozone depleting substances and greenhouse gases with the synthesis of valuable organic compounds, complements the concept of atom transfer radical addition, and provides direct synthetic access to the CCl2F group as a structural motif. The broad substrate scope and multifunctionalized product class enable various subsequent transformations.
Article
Chemistry, Organic
Fabian Hoffmann, Anna-Lena Leistner, Susanne Kirchner, Burkhard Luy, Claudia Muhle-Goll, Zbigniew Pianowski
Summary: This study presents a structural analysis of peptide-derived photochromic supramolecular hydrogels using advanced techniques of nuclear magnetic resonance. The hydrogels were physically loaded with a selection of biologically related compounds. The results provide detailed and correct understanding of the loading process and will guide the correct design of phototriggered drug delivery systems.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Helena Simek Tosino, Andre Jung, Olaf Fuhr, Claudia Muhle-Goll, Nicole Jung, Stefan Braese
Summary: A photochemical cyclization of F-tagged, o-alkynylated N-alkylamides to indoles catalyzed by a specific iridium complex is described. This reaction involves a rearrangement due to an electron withdrawing group, resulting in the formation of 3-acylindoles. A four-step reaction sequence including the photoreaction has been developed and optimized, leading to the synthesis of 16 derivatives with different modifications in good yields.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Polymer Science
Leon Klose, Neele Meyer-Heydecke, Sasipa Wongwattanarat, Jennifer Chow, Pablo Perez Garcia, Camille Carre, Wolfgang Streit, Garabed Antranikian, Ana Malvis Romero, Andreas Liese
Summary: Epoxy resins are highly valued for their properties and applications, but the challenge lies in their non-biodegradability and unsustainable recycling methods. Recent progress has been made in plastic biodegradation, but mainly focuses on other polymers, leaving epoxy underrepresented. This review examines the approaches and challenges in biodegradation and recycling of epoxy, and highlights the analytical techniques used.
Article
Chemistry, Physical
Daniela Eixenberger, Aditya Kumar, Saskia Klinger, Nico Scharnagl, Ayad W. H. Dawood, Andreas Liese
Summary: The flow properties of packed bed reactors can be enhanced using 3D printing to create optimized structures that improve mass transfer and catalyst conversion rates. Surface-induced polymerization can increase the number of enzymes and enable smart reaction control. This publication demonstrates the application of surface-induced polymerization on 3D-printed structures for enzyme carriers.
Article
Biochemistry & Molecular Biology
Ana Malvis Romero, Jose Julian Morales, Leon Klose, Andreas Liese
Summary: Ulvan is a sulfated polysaccharide extracted from green macroalgae with unique properties. This study investigates the potential of Ulva fenestrata as a source of ulvan and explores the effect of extraction methods and time on ulvan yield. Results show that longer extraction times and the combination of enzymatic and ultrasound-assisted extraction can increase the ulvan yield.
