Current strategies to generate mature human induced pluripotent stem cells derived cholangiocytes and future applications

Liver-Regenerative Transplantation: Regrow and Reset

(2016) A. Collin de l'Hortet et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

(2016) Kazuo Takayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three-dimensional printing and pediatric liver disease

(2016) Naim Alkhouri et al.   CURRENT OPINION IN PEDIATRICS

Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma

(2016) Xueru Mu et al.   GASTROENTEROLOGY

Hepatocyte-like cells derived from induced pluripotent stem cells

(2016) Namita Roy-Chowdhury et al.   Hepatology International

10th anniversary of iPS cells: the challenges that lie ahead

(2016) Takashi Aoi   JOURNAL OF BIOCHEMISTRY

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

„Liver engineering“ als neue Quelle von Spenderorganen

(2015) F. Mußbach et al.   CHIRURG

Animal Models of Primary Biliary Cirrhosis

(2015) Tomohiro Katsumi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Bile Acids in Physiology, Pathology and Pharmacology

(2015) Jose J.G. Marin et al.   CURRENT DRUG METABOLISM

Orchestrating liver development

(2015) M. Gordillo et al.   DEVELOPMENT

Genetic Contributors and Modifiers of Biliary Atresia

(2015) Anya Mezina et al.   DIGESTIVE DISEASES

IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism

(2015) Daisaku Yamada et al.   HEPATOLOGY

Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

(2015) Patricia Munoz-Garrido et al.   JOURNAL OF HEPATOLOGY

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

(2015) Thiago M De Assuncao et al.   LABORATORY INVESTIGATION

The Cholangiopathies

(2015) Konstantinos N. Lazaridis et al.   MAYO CLINIC PROCEEDINGS

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Genome-wide association studies in biliary atresia

(2015) Mylarappa Ningappa et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic Cholangiocarcinoma of Syrian Golden Hamsters Induced by Clonorchis sinensis and N-Nitrosodimethylamine

(2015) Md. Hafiz Uddin et al.   PLoS Neglected Tropical Diseases

MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment

(2015) Maria Pisarello et al.   Journal of Clinical Medicine

Animal Models in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

(2014) Marion J. Pollheimer et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

(2014) Noushin Dianat et al.   HEPATOLOGY

Emerging roles of Notch signaling in liver disease

(2014) Fabian Geisler et al.   HEPATOLOGY

Intrasplenic Transplanted Adult Rat Isolated Hepatocyte Fraction But Not Cholangiocytes Forms Bile Canaliculi

(2014) W.L. Olszewski et al.   TRANSPLANTATION PROCEEDINGS

Human Induced Pluripotent Stem Cells in Hepatology

(2013) Sabine Gerbal-Chaloin et al.   AMERICAN JOURNAL OF PATHOLOGY

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes

(2013) S. Ogawa et al.   DEVELOPMENT

Cocarcinogenic Effects of Intrahepatic Bile Acid Accumulation in Cholangiocarcinoma Development

(2013) Elisa Lozano et al.   MOLECULAR CANCER RESEARCH

FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway

(2013) Dongju Jung et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Neonatal liver physiology

(2013) James Grijalva et al.   Seminars in Pediatric Surgery

The Zebrafish as a Model to Study Polycystic Liver Disease

(2013) Pamela S. Tietz Bogert et al.   Zebrafish

Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells

(2013) Nicholas R.F. Hannan et al.   Stem Cell Reports

α1- and α5-containing Laminins Regulate the Development of Bile Ducts via β1 Integrin Signals

(2012) Naoki Tanimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level

(2012) Karin Norrman et al.   METHODS

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells

(2012) Takamichi Miyazaki et al.   Nature Communications

TGR5 in the Biliary Tree

(2011) Verena Keitel et al.   DIGESTIVE DISEASES

Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells

(2011) Rodolphe Carpentier et al.   GASTROENTEROLOGY

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol

(2011) Yu-Fan Chen et al.   HEPATOLOGY

A Whole-Organ Regenerative Medicine Approach for Liver Replacement

(2011) Alejandro Soto-Gutierrez et al.   TISSUE ENGINEERING PART C-METHODS

Generation of murine hepatic lineage cells from induced pluripotent stem cells

(2010) Hui Gai et al.   DIFFERENTIATION

The use of whole organ decellularization for the generation of a vascularized liver organoid

(2010) Pedro M. Baptista et al.   HEPATOLOGY

Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

(2009) Zhihua Song et al.   CELL RESEARCH

Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells

(2009) Yoshikazu Hirose et al.   EXPERIMENTAL CELL RESEARCH

Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies

(2009) Frédéric P. Lemaigre   GASTROENTEROLOGY

Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9

(2009) Aline Antoniou et al.   GASTROENTEROLOGY

Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice

(2009) Erin E. Sparks et al.   HEPATOLOGY

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

(2009) Thomas Touboul et al.   HEPATOLOGY

Biliary differentiation and bile duct morphogenesis in development and disease

(2009) Peggy Raynaud et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Foxa1 and Foxa2 regulate bile duct development in mice

(2009) Zhaoyu Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice

(2009) Nalu Navarro-Alvarez et al.   JOURNAL OF HEPATOLOGY

Exploring the genetic architecture of neonatal hyperbilirubinemia

(2009) Jon F. Watchko et al.   Seminars in Fetal & Neonatal Medicine

Embryology of Extra- and Intrahepatic Bile Ducts, the Ductal plate

(2008) T. Roskams et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes

(2008) Hesham Basma et al.   GASTROENTEROLOGY

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

(2008) Timo H.-W. Lüdtke et al.   HEPATOLOGY

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

(2008) Xinping Tan et al.   HEPATOLOGY

Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts

(2008) Akihide Kamiya et al.   HEPATOLOGY

Liver-specific inactivation ofNotch2, but notNotch1, compromises intrahepatic bile duct development in mice

(2008) Fabian Geisler et al.   HEPATOLOGY

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA