Article
Cell Biology
Ruidong Li, Wenwen Zhang, Zhengjian Yan, Wei Liu, Jiaming Fan, Yixiao Feng, Zongyue Zeng, Daigui Cao, Rex C. Haydon, Hue H. Luu, Zhong-Liang Deng, Tong-Chuan He, Yulong Zou
Summary: mHotair plays a crucial role in BMP9-induced MSC osteogenesis by targeting cell cycle and proliferation, as demonstrated by increased expression in bones, and its regulation of osteogenic differentiation, chondrogenic markers, and adipogenic markers.
Article
Biochemistry & Molecular Biology
Yukun Mao, Na Ni, Linjuan Huang, Jiaming Fan, Hao Wang, Fang He, Qing Liu, Deyao Shi, Kai Fu, Mikhail Pakvasa, William Wagstaff, Andrew Blake Tucker, Connie Chen, Russell R. Reid, Rex C. Haydon, Sherwin H. Ho, Michael J. Lee, Tong-Chuan He, Jian Yang, Le Shen, Lin Cai, Hue H. Luu
Summary: The study shows that BMP9 can induce osteogenic and adipogenic differentiation of MSCs by upregulating the expression of AGO proteins. Silencing individual AGO expression leads to a decrease in osteogenic marker activity, while silencing all four AGO genes significantly diminishes BMP9-induced differentiation and bone formation of MSCs. AGO proteins and small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs.
Article
Cell Biology
Fu-Shu Li, Pei-Pei Li, Ling Li, Yan Deng, Ying Hu, Bai-Cheng He
Summary: The inhibitory effects of PTEN on BMP9's osteogenic potential may be partially mediated through decreasing the expression of Wnt10b via the disturbance of interaction between CREB and BMP/Smad signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Kostina, Arseniy Lobov, Daria Semenova, Artem Kiselev, Polina Klausen, Anna Malashicheva
Summary: Despite significant progress in bone tissue regeneration, the early mechanisms of osteogenic differentiation remain poorly understood. Various cells can undergo osteogenic transformation, with Notch signaling playing a key role in this process. Research demonstrates differences in the ability of different cell types to undergo Notch-dependent osteogenic differentiation.
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Bo Jia, Jun Chen, Qin Wang, Xiang Sun, Jiusong Han, Fernando Guastaldi, Shijian Xiang, Qingsong Ye, Yan He
Summary: The study reveals that SIRT6 physically interacts with DNMT1 protein, deacetylating and destabilizing it, leading to the activation of NOTCH1 and NOTCH2, which promotes the osteogenic differentiation of ADSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Junhao Yin, Zhanglong Zheng, Xiaoli Zeng, Yijie Zhao, Zexin Ai, Miao Yu, Yang'ou Wu, Jirui Jiang, Jia Li, Shengjiao Li
Summary: The study revealed that lncRNA Malat1 plays a critical role in maintaining the osteogenic potential of aging BMSCs by sponging miR-129-5p. This suggests that Malat1 and miR-129-5p play important roles in regulating the osteogenic ability of BMSCs.
Article
Oncology
Guiwen Ye, Peng Wang, Zhongyu Xie, Jinteng Li, Guan Zheng, Wenjie Liu, Qian Cao, Ming Li, Shuizhong Cen, Zhaofeng Li, Wenhui Yu, Yanfeng Wu, Huiyong Shen
Summary: This study identified a novel long noncoding RNA, HHAS1, that facilitates bone marrow-derived mesenchymal stem cell osteogenic differentiation, and proposed a role for the IRF2/HHAS1/miR-204-5p/RUNX2 axis in the regulation of BMSC osteogenesis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yuwen Zhao, Kiarra Richardson, Rui Yang, Zoe Bousraou, Yoo Kyoung Lee, Samantha Fasciano, Shue Wang
Summary: Osteoporosis is a common bone and metabolic disease characterized by bone density loss and microstructural degeneration. This study investigates the regulatory role of Notch signaling during osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) exposed to physiologically relevant fluid shear stress using a locked nucleic acid (LNA)/DNA nanobiosensor. The results provide evidence that shear stress regulates osteogenic differentiation through Notch signaling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Anatomy & Morphology
Li Xu, Caixia Ji, Tingting Yu, Jinyong Luo
Summary: Diseases such as bone nonunion and osteoporosis seriously impact people's quality of life, and bone tissue engineering using mesenchymal stem cells is an effective solution. Previous studies have shown the efficacy of BMP9 in promoting osteogenic differentiation of MSCs, but the underlying mechanisms remain unclear. This study investigated the role of Gli1 and Gli2 in BMP9-induced osteogenic differentiation of MSCs. The results demonstrated that inhibition of Gli1 and Gli2 weakened BMP9-induced osteogenic differentiation and reduced the expression of key osteogenic markers, as well as the activation of p-Smad1/5/8 and p-p38 induced by BMP9. In conclusion, this study highlights the importance of Gli1 and Gli2 in BMP9-induced osteogenic differentiation.
Article
Medicine, Research & Experimental
Xintong Yao, Peipei Li, Yixuan Deng, Yuanyuan Yang, Honghong Luo, Baicheng He
Summary: The study found that the p53 gene is expressed at higher levels in MSCs from patients with osteoporosis and is associated with core genes related to osteoporosis. p53 can serve as a therapeutic target for bone-related diseases by promoting bone differentiation of MSCs and inhibiting adipose differentiation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jialin Liu, Yuan Yao, Jinyong Huang, Hao Sun, Yixuan Pu, Mengting Tian, Meijie Zheng, Huiyu He, Zheng Li
Summary: This study investigated the expression profiles of lncRNAs, miRNAs, and mRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs). The study identified key molecules and pathways involved in this process, providing potential molecular targets for the management of bone defect.
Article
Cell Biology
Xin-Hu Yin, Xiao-Yuan Wang, Shi-Chang Liu, Liang Yan, Bao-Rong He, Ding-Jun Hao, Ming Yang, Zhong-Kai Liu
Summary: This study revealed that the down-regulation of HHIP due to reduced lncRNA HHIP-AS1 promoted the osteogenic differentiation of BM-MSCs by removing the suppression of the Hedgehog signaling pathway.
Article
Pharmacology & Pharmacy
Ying Xing, Mi-Shuai Zhang, Jian-Hui Xiao, Ru-Ming Liu
Summary: This study found that galangin can promote the osteogenic differentiation of human amniotic mesenchymal stem cells (hAMSCs) through the JAK2/STAT3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Avinash Sanap, Kalpana Joshi, Tejas Shah, Girish Tillu, Ramesh Bhonde
Summary: The study showed that Piper longum L. fruit extract significantly increased proliferation of WJMSCs and enhanced Ca2+ accumulation and matrix mineralization, along with promoting alkaline phosphatase (ALP) activity and the expression of key gene mRNAs. This suggests that the fruit extract can enhance osteogenic differentiation of WJMSCs, potentially serving as an anti-osteoporotic agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Xinyi Yu, Feng Liu, Liyi Zeng, Fang He, Ruyi Zhang, Shujuan Yan, Zongyue Zeng, Yi Shu, Chen Zhao, Xingye Wu, Jiayan Lei, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Xiaojuan Ji, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Bo Huang, Wei Liu, Bo Zhang, Zhengyu Dai, Xi Wang, Bo Liu, Rex C. Haydon, Hue H. Luu, Hua Gan, Tong-Chuan He, Liqun Chen
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Medicine, Research & Experimental
Yue Gu, Aifang Li, Hui Sun, Xueru Li, He Zha, Jiali Zhao, Jiaqing Xie, Zongyue Zeng, Lan Zhou
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Materials Science, Biomaterials
Chen Zhao, Zongyue Zeng, Nader Taheri Qazvini, Xinyi Xu, Ruyi Zhang, Shujuan Yan, Yi Shu, Yunxiao Zhu, Chongwen Duan, Elliot Bishop, Jiayan Lei, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Xiaojuan Ji, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Wei Liu, Bo Huang, Yixiao Feng, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Leonardo Oliveira, Aravind Athiviraham, Michael J. Lee, Jennifer Moriatis Wolf, Guillermo A. Ameer, Russell R. Reid, Tong-Chuan He, Wei Huang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Chen Zhao, Zongyue Zeng, Nader Taheri Qazvini, Xinyi Xu, Ruyi Zhang, Shujuan Yan, Yi Shu, Yunxiao Zhu, Chongwen Duan, Elliot Bishop, Jiayan Lei, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Xiaojuan Ji, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Wei Liu, Bo Huang, Yixiao Feng, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Leonardo Oliveira, Aravind Athiviraham, Michael J. Lee, Jennifer Moriatis Wolf, Guillermo A. Ameer, Russell R. Reid, Tong-Chuan He, Wei Huang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Biochemistry & Molecular Biology
Yi Shu, Chao Yang, Xiaojuan Ji, Linghuan Zhang, Yang Bi, Ke Yang, Mengjia Gong, Xing Liu, Qi Guo, Yuxi Su, Xiangyang Qu, Guoxin Nan, Chen Zhao, Zongyue Zeng, Xinyi Yu, Ruyi Zhang, Shujuan Yan, Jiayan Lei, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Cheng Gong, Chengfu Yuan, Wei Liu, Bo Huang, Yixiao Feng, Bo Zhang, Zhengyu Dai, Yi Shen, Wenping Luo, Xi Wang, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Jennifer Moriatis Wolf, Michael J. Lee, Tong-Chuan He, Yasha Li
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Xinyi Yu, Yunfeng Xia, Liyi Zeng, Xi Zhang, Liqun Chen, Shujuanyan Yan, Ruyi Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Shifeng Huang, Jiayan Lei, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Wenping Luo, Xi Wang, Hongmei Zhang, Rex C. Haydon, Hue H. Luu, Tong-Chuan He, Hua Gan
SCIENTIFIC REPORTS
(2018)
Article
Medicine, Research & Experimental
Jing Cui, Wenwen Zhang, Enyi Huang, Jia Wang, Junyi Liao, Ruidong Li, Xinyi Yu, Chen Zhao, Zongyue Zeng, Yi Shu, Ruyi Zhang, Shujuan Yan, Jiayan Lei, Chao Yang, Ke Wu, Ying Wu, Shifeng Huang, Xiaojuan Ji, Alexander Li, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Wei Liu, Bo Huang, Yixiao Feng, Liping An, Bo Zhang, Zhengyu Dai, Yi Shen, Wenping Luo, Xi Wang, Ailong Huang, Hue H. Luu, Russell R. Reid, Jennifer Moriatis Wolf, Gopal Thinakaran, Michael J. Lee, Tong-Chuan He
LABORATORY INVESTIGATION
(2019)
Article
Nanoscience & Nanotechnology
Chen Zhao, Nader Taheri Qazvini, Monirosadat Sadati, Zongyue Zeng, Shifeng Huang, Ana Losada De la Lastra, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Bo Liu, Yan Lei, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Aravind Athiviraham, Michael J. Lee, Jennifer Moriatis Wolf, Russell R. Reid, Matthew Tirrell, Wei Huang, Juan J. de Pablo, Tong-Chuan He
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Biotechnology & Applied Microbiology
Jiaming Fan, Yixiao Feng, Ruyi Zhang, Wenwen Zhang, Yi Shu, Zongyue Zeng, Shifeng Huang, Linghuan Zhang, Bo Huang, Di Wu, Bo Zhang, Xi Wang, Yan Lei, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Bin Liu, William Wagstaff, Fang He, Xiaoxing Wu, Jing Zhang, Jennifer Moriatis Wolf, Michael J. Lee, Rex C. Haydon, Hue H. Luu, Ailong Huang, Tong-Chuan He, Shujuan Yan
CANCER GENE THERAPY
(2020)
Article
Biotechnology & Applied Microbiology
Jian-feng Zheng, Shaozhong He, Zongyue Zeng, Xinqi Gu, Lei Cai, Guangying Qi
Article
Biochemical Research Methods
Xi Wang, Chengfu Yuan, Bo Huang, Jiaming Fan, Yixiao Feng, Alexander J. Li, Bo Zhang, Yan Lei, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Di Wu, Xian Chen, Bin Liu, William Wagstaff, Fang He, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Rex C. Haydon, Hue H. Luu, Michael J. Lee, Jennifer Moriatis Wolf, Ailong Huang, Tong-Chuan He, Zongyue Zeng
ACS SYNTHETIC BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Zongyue Zeng, Bo Huang, Xi Wang, Jiaming Fan, Bo Zhang, Lijuan Yang, Yixiao Feng, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Mikhail Pakvasa, William Wagstaff, Alexander J. Li, Bin Liu, Huimin Ding, Yongtao Zhang, Changchun Niu, Meng Wu, Xia Zhao, Jennifer Moriatis Wolf, Michael J. Lee, Ailong Huang, Hue H. Luu, Rex C. Haydon, Tong-Chuan He
JOURNAL OF ADVANCED RESEARCH
(2020)
Article
Oncology
Rui Chen, Xi Wang, Shixian Zhou, Zongyue Zeng
Summary: Growing evidence indicates that the up-regulated lncRNA HOXA-AS2 in oral squamous cell carcinoma (OSCC) correlates with poor clinical outcomes by directly binding to miR-567 and increasing CDK8 expression, thus promoting cell proliferation. Further exploration into the prognostic value of lncRNA HOXA-AS2 is warranted in future studies.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xinyi Yu, Liqun Chen, Ke Wu, Shujuan Yan, Ruyi Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Shifeng Huang, Jiayan Lei, Xiaojuan Ji, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Wenping Luo, Xi Wang, Bo Liu, Rex C. Haydon, Hue H. Luu, Tong-Chuan He, Hua Gan
Review
Biochemistry & Molecular Biology
Yixiao Feng, Mia Spezia, Shifeng Huang, Chengfu Yuan, Zongyue Zeng, Linghuan Zhang, Xiaojuan Ji, Wei Liu, Bo Huang, Wenping Luo, Bo Liu, Yan Lei, Scott Du, Akhila Vuppalapati, Hue H. Luu, Rex C. Haydon, Tong-Chuan He, Guosheng Ren