Article
Medicine, Research & Experimental
Di -Di Zhang, Xiao-Lin Sun, Zhao-Yuan Liang, Xin-Ya Wang, Li-Na Zhang
Summary: This study found that FAM96A/B is down-regulated in breast cancer. Overexpression of FAM96A/B suppresses cell proliferation, invasion, and migration, induces apoptosis and causes cell cycle arrest in breast cancer cells. Conversely, knockdown of FAM96A/B has the opposite effects. Furthermore, it was demonstrated that FAM96A/B overexpression inhibits EMT and Wnt/13-catenin pathway, while FAM96A/B knockdown promotes EMT and Wnt/13-catenin pathway. These findings suggest that FAM96A/B may function as tumor suppressor genes and inhibit breast cancer progression by modulating the Wnt/13-catenin pathway.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Oncology
Jianping Chen, Dandan Wang, Hongqiang Chen, Jin Gu, Xiao Jiang, Fei Han, Jia Cao, Wenbin Liu, Jinyi Liu
Summary: Our study reveals that TMEM196 functions as a novel suppressor of lung cancer metastasis through the Wnt/beta-catenin signaling pathway. TMEM196 mRNA and protein expression levels are significantly decreased in lung cancer tissues and cells. Low expression of TMEM196 is associated with poor prognosis in clinical patients. TMEM196 strongly inhibits tumor metastasis and progression in vitro and in vivo. Mechanistically, TMEM196 inhibits the Wnt signaling pathway and represses beta-catenin promoter transcription. Silencing TMEM196 results in upregulation of beta-catenin and downstream target genes MMP2 and MMP7. Inhibition of beta-catenin expression attenuates the antimetastatic effect of TMEM196 in lung cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qinmei Ma, Jialin Yu, Xu Zhang, Xiaoling Wu, Guangcun Deng
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in cell development, proliferation, differentiation, apoptosis and autophagy. The interplay between Wnt/β-catenin-regulated apoptosis and autophagy is of significant functional importance in various diseases. This article summarizes the recent studies on the role of the Wnt/β-catenin signaling pathway in apoptosis and autophagy, and draws the following conclusions: a) Wnt/β-catenin generally has a positive regulatory role in apoptosis, but there is also evidence of a negatively regulated relationship; b) Wnt/β-catenin influences the occurrence and development of autophagy by regulating autophagy-related factors, and these factors in turn affect the Wnt/β-catenin pathway; c) Wnt/β-catenin always balances the molecular damage caused by the crosstalk between autophagy and apoptosis in a compensatory manner. Understanding the specific role of the Wnt/β-catenin signaling pathway during different stages of autophagy and apoptosis may provide new insights into the progression of related diseases regulated by this pathway.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Oncology
Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen, Kuancan Liu
Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
BIOMARKER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Vamshikrishna Malyla, Keshav Raj Paudel, Gabriele De Rubis, Nicole G. Hansbro, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer has the highest mortality rate worldwide, and cigarette smoking is a major etiological factor. This study found that cigarette smoke extract treatment can upregulate WNT/ss-β-catenin signaling and induce tumorigenesis in healthy human bronchial epithelial cells. Furthermore, extracellular vesicles obtained from cigarette smoke exposed cells were found to induce migration and upregulate oncology proteins in recipient cells.
Article
Immunology
Ruqing Gao, Xiaoqiang Zheng, Aimin Jiang, Wangxiao He, Tianya Liu
Summary: The tumor-specific biomimetic Wnt pathway suppressor CM-CA effectively inhibits the Wnt/β-catenin signaling pathway and cellular proliferation in lung adenocarcinoma, leading to significant tumor growth inhibition. CM-CA also promotes T cell infiltration and enhances the immune response within tumor tissues.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wenping Song, Xuan Wu, Cheng Cheng, Ding Li, Jinhua Chen, Wenzhou Zhang
Summary: This study investigates the impact of ARHGAP9 on lung adenocarcinoma (LUAD) metastasis and sheds light on its molecular mechanism. The findings demonstrate that downregulated ARHGAP9 is correlated with poor prognosis in LUAD patients. ARHGAP9 knockdown enhances LUAD cell proliferation, migration, and invasion while suppressing cell apoptosis and G0G1 cell cycle arrest. RNA sequencing analysis indicates that ARHGAP9 knockdown reduces the expression of DKK2. Silencing ARHGAP9 and overexpressing DKK2 reverses the promoted effects on LUAD cell proliferation, migration, and invasion, and reduces the activity of the Wnt/beta-catenin signaling pathway. Thus, ARHGAP9 knockdown promotes LUAD metastasis by activating the Wnt/beta-catenin signaling pathway through suppressing DKK2, offering a potential strategy for LUAD treatment.
Article
Dentistry, Oral Surgery & Medicine
Qiang Zhang, Qi Zhang, Xiao Yan, Liping Wang, Xiao Yuan
Summary: This study evaluated the effects of different dimensional wrinkled topography on the osteogenic differentiation of MC3T3-E1 cells and explored the underlying mechanisms. The results showed that wrinkled topographies activated the autophagy-mediated Wnt/β-catenin signaling pathway and affected the osteogenic differentiation of MC3T3-E1 cells.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Minghan Guan, Yifeng Huang, Xiaowen Lin
Summary: This study found that sufentanil can inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition of lung cancer cells by regulating the Wnt/beta-catenin signaling pathway.
Article
Pharmacology & Pharmacy
Hua Wang, Yinfeng Tan, Hao Jia, Danqi Liu, Rangru Liu
Summary: In this study, it was found that Posaconazole (POS) has potential antitumor activity against glioblastoma (GBM) and its molecular mechanisms were elucidated. POS can weaken the stemness of CSCs and promote autophagy induction. It was also revealed that POS targets survivin and suppresses the Wnt/β-catenin signaling pathway in GBM. This study provides an experimental foundation for the development of POS as a CSCs-targeting antitumor drug for GBM treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huanhuan Li, Fan Tong, Rui Meng, Ling Peng, Jiaojiao Wang, Ruiguang Zhang, Xiaorong Dong
Summary: In this study, WNT5A protein was found to be significantly downregulated in BM tissues and EGFR-mutant samples of NSCLC patients, with overexpression inhibiting the growth and migration of EGFR-mutant cells. Further research revealed that WNT5A is negatively regulated by E2F1 and that its repression is dependent on the ERK1/2 pathway in EGFR-mutant cells. These findings suggest that targeting the ERK1/2-E2F1-WNT5A pathway could be an effective strategy for treating BM in EGFR-mutant NSCLC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)