Article
Cell Biology
Xin Yi, Conghui Hu, Chen Zhang, Kai Shao, Hui Sun, Yuanhui Jiang, Nianfeng Sun, Xuting Zhi
Summary: The study revealed that KIAA1522 is overexpressed in colorectal carcinoma and its distant metastasis, associated with poor clinicopathological features and low overall survival rate. Functional studies suggested that KIAA1522 promotes proliferation, invasion, and migration of colorectal carcinoma, possibly through upregulating the Notch signaling pathway.
CELLULAR SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Qiken Li, Gang Wang, Jun Luo, Bo Li, Weiping Chen
Summary: Among T1 colorectal cancer patients, about 1.8% have synchronous distant metastasis and 8.5% have lymph node metastasis. Factors such as younger age, positive CEA, larger tumor size, and lymph node metastasis are significantly associated with an increased risk of synchronous distant metastasis. Older age, female gender, Black race, positive CEA, and lymph node metastasis are correlated with worse survival in patients with synchronous distant metastasis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jie Cheng, Yao-Jia Lao, Qian Wang, Kai Huang, Juan-Li Mou, Jia-Hui Feng, Fan Hu, Meng-Lu Lin, Jun Lin
Summary: In young-onset CRC patients, preoperative CEA positive was found to be a significant predictor of distant metastasis (DM). A novel nomogram containing clinical and pathological features was established to predict DM in advanced CRC patients younger than 50 years old, showing high accuracy and stability. This tool can serve as an early alert for clinicians to DM and help in developing better clinical treatment regimens.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiaxian Zhu, Ting Long, Lingfang Gao, Yan Zhong, Ping Wang, Xiaoyan Wang, Zuguo Li, Zhiyan Hu
Summary: In this study, RPL21 was found to be involved in promoting CRC metastasis by regulating FA formation in a LAMP3-dependent manner. The interaction between RPL21 and LAMP3 may serve as a potential therapeutic target against CRC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Rita Moreno, Sourav Banerjee, Angus W. Jackson, Jean Quinn, Gregg Baillie, Jack E. Dixon, Albena T. Dinkova-Kostova, Joanne Edwards, Laureano de la Vega
Summary: In triple-negative breast cancer (TNBC) cells, DYRK2 phosphorylates HSF1 to promote its nuclear stability and transcriptional activity, with DYRK2 depletion reducing HSF1 activity. Moreover, DYRK2 levels positively correlate with active HSF1 in TNBC tumors and associate with poor prognosis, suggesting DYRK2 may be promoting TNBC.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Alya R. Alnuaimi, Justus Bottner, Vidhya A. Nair, Nival Ali, Razaz Alnakhli, Eva Dreyer, Iman M. Talaat, Hauke Busch, Sven Perner, Jutta Kirfel, Rifat Hamoudi, Wael M. Abdel-Rahman
Summary: Colorectal cancer is a deadly disease with increasing rates worldwide. Caldesmon (CaD) has emerged as a promising biomarker for diagnosis and therapy. It was found that l-CaD is overexpressed in colorectal cancer and associated with preinvasive stages, while h-CaD is expressed in smooth muscle cells but not in cancer cells or normal colon mucosal epithelial cells. These findings have significant implications for the management of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang
Summary: This study identifies ketogenesis as a critical regulator of the tumor microenvironment in colorectal cancer and suggests the potential for ketogenic diets as a metabolic strategy to overcome immunosuppression and prolong survival.
Article
Biochemistry & Molecular Biology
Kathleen M. McAndrews, Karina Vazquez-Arreguin, Changsoo Kwak, Hikaru Sugimoto, Xiaofeng Zheng, Bingrui Li, Michelle L. Kirtley, Valerie S. LeBleu, Raghu Kalluri
Summary: The study demonstrates that alpha SMA(+) CAFs in CRC exert tumor-restraining functions via BMP4/TGF beta 1 paracrine signaling that serves to suppress Lgr5(+) CSCs and promote anti-tumor immunity, ultimately limiting CRC progression.
Article
Biochemistry & Molecular Biology
Tomasz Wenta, Anette Schmidt, Qin Zhang, Raman Devarajan, Prateek Singh, Xiayun Yang, Anne Ahtikoski, Markku Vaarala, Gong-Hong Wei, Aki Manninen
Summary: This study investigated the role of PTEN and hemidesmosomal adhesions in prostate cancer and found that their simultaneous loss induces various tumorigenic properties, including proliferation, migration, resistance to anoikis, apoptosis, and increased metastatic capacity. These effects are dependent on plectin and are mediated by the activation of EGFR/PI3K/Akt and FAK/Src pathways.
Article
Biochemistry & Molecular Biology
Jiawei Sun, Zizhen Zhang, Jingyu Chen, Meng Xue, Xia Pan
Summary: High expression of ELTD1 is correlated with lymph node metastasis and poor outcomes in colorectal cancer, promoting invasion and metastasis of CRC both in vitro and in vivo. Additionally, ELTD1 accelerates MMP2 transcriptional activity, potentially serving as a novel target for CRC metastasis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Wei Liu, Jin Meng, Rongjun Su, Changjun Shen, Shuai Zhang, Yantao Zhao, Wenqi Liu, Jiang Du, Shuai Zhu, Pan Li, Zhigang Wang, Xiaoxia Li
Summary: This study elucidates the mechanism by which long non-coding RNA TUG1 promotes tumor formation in colorectal cancer. SP1 regulates TUG1 and the miR-421/KDM2A/ERK axis, providing novel insights into the development of colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Leonard Simon Brandenburg, Marc Christian Metzger, Philipp Poxleitner, Pit Jacob Voss, Kirstin Vach, Johannes Hell, Konstantin Hasel, Julia Vera Weingart, Steffen Jochen Schwarz, Michael Andreas Ermer
Summary: This study investigated the association between red blood cell (RBC) transfusions and the occurrence of distant metastasis (M+) after surgical treatment of oral squamous cell carcinoma (OSCC). The study found a positive correlation between RBC transfusion and M+, suggesting that RBC transfusions may be an independent prognostic factor. Therefore, caution should be taken in the perioperative management of OSCC patients regarding the administration of RBC transfusions.
Article
Cell Biology
Huamei Wei, Zuoming Xu, Liucui Chen, Qing Wei, Zihua Huang, Guoman Liu, Wenchuan Li, Jianchu Wang, Qianli Tang, Jian Pu
Summary: This study identified a HCC-related lncRNA, PAARH, which facilitated HCC progression and angiogenesis by upregulating HOTTIP and activating HIF-1α/VEGF signaling.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yuhan Hu, Qingzu Gao, Shuai Ma, Pei Yu, Shuang Ding, Xiaofei Yao, Zheying Zhang, Shuya Lu, Manman Lu, Jinghang Zhang, Yanling Wang, Xinlai Qian, Jiateng Zhong
Summary: FMR1, a new m(6)A reader, is upregulated in colorectal cancer (CRC) and promotes tumor growth and metastasis by recognizing the m(6)A modification site in EGFR mRNA, thereby maintaining its stability and expression. This study identifies the METTL3/FMR1/EGFR axis as a potential target for early therapeutic intervention in CRC progression.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Hibah Shaath, Salman M. Toor, Mohamed Abu Nada, Eyad Elkord, Nehad M. Alajez
Summary: The study revealed alterations in miRNA, mRNA, and lncRNA expression in CRC, identified activated signaling networks and characteristics in CRC through computational analysis and functional annotation. It also uncovered complex associations between miRNAs and mRNAs as well as potential interactions between lncRNAs and miRNAs.
SCIENTIFIC REPORTS
(2021)
