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Biochemistry & Molecular Biology
Mun-Ock Kim, Jae-Won Lee, Jae Kyoung Lee, Yu Na Song, Eun Sol Oh, Hyunju Ro, Dahye Yoon, Yun-Hwa Jeong, Ji-Yoon Park, Sung-Tae Hong, Hyung Won Ryu, Su Ui Lee, Dae Young Lee
Summary: Korean black ginseng extract inhibits airway inflammation and mucus secretion by decreasing the activation of TAK1, suggesting it could be a potential adjuvant in the treatment of airway inflammatory diseases caused by cigarette smoke.
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Biochemistry & Molecular Biology
Tzu-Yin Chen, Chia-Hao Liu, Tsung-Hsien Chen, Mei-Ru Chen, Shan-Wen Liu, Pinpin Lin, Kurt Ming-Chao Lin
Summary: The role of epithelial-mesenchymal transition in lung diseases and cancer related to cigarette smoking is significant. Adipose-derived stem cell-conditioned medium shows protective effects against cigarette smoke-induced cell death and EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Plant Sciences
Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen
Summary: DHQ significantly reverses cigarette smoke-induced ferroptosis via a Nrf2-dependent signaling pathway, exerting protective effects in both in vivo mouse models and in vitro cell cultures.
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Biochemistry & Molecular Biology
Je-Oh Lim, Se-Jin Lee, Woong-Il Kim, So-Won Pak, Jong-Choon Kim, Joong-Sun Kim, Young-Kwon Cho, In-Chul Lee, In-Sik Shin
Summary: The study showed that melatonin can reduce SiONPs-induced lung inflammation by downregulating the TXNIP/MAPKs/AP-1 signaling pathway, leading to decreased production of inflammatory mediators and accumulation of inflammatory cells.
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Cell Biology
Kyoung-Hee Lee, Jisu Woo, Ji Yeon Kim, Chang-Hoon Lee, Chul-Gyu Yoo
Summary: The study found that CSE may impair cytokine response by decreasing the expression levels of p300. While CS has been shown to affect macrophage immune function, its molecular mechanism is not fully understood.
CELLULAR SIGNALLING
(2021)
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Cell Biology
Zhewei Zhao, Xuebin Wang, Rui Zhang, Baitao Ma, Shuai Niu, Xiao Di, Leng Ni, Changwei Liu
Summary: The research suggests that melatonin may protect against smoking-induced vascular injury and atherosclerosis through the Nrf2/ROS/NLRP3 signaling pathway.
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Food Science & Technology
Sun Young Jung, Gun-Dong Kim, Dae Woon Choi, Dong-Uk Shin, Ji-Eun Eom, Seung Yong Kim, Ok Hee Chai, Hyun-Jin Kim, So-Young Lee, Hee Soon Shin
Summary: The study found that Epilobium species extract can inhibit inflammatory cell recruitment and symptoms in COPD mice, as well as attenuate inflammatory gene expression by suppressing MAPKs and NF kappa B activity. Additionally, identified phytochemical constituents of Epilobium species extract showed anti-inflammatory effects.
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Medicine, Research & Experimental
Hsin-Kuo Ko, Yi-Han Hsiao, Mei-Jy Jeng, De-Ming Yang, Pei-Ku Chen, Kang-Cheng Su, Kun-Ta Chou, Diahn-Warng Perng
Summary: This study found that TGF-beta 2 reduced CSE-induced IL-8 production through the Smad3 signaling pathway in PBECs, and alleviated lung inflammation and injury caused by cigarette smoke. TGF-beta 2 has an anti-inflammatory effect on cigarette smoke-induced lung inflammation.
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Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Harsha Nagar, Sungmin Kim, Ikjun Lee, Seonhee Kim, Su-Jeong Choi, Shuyu Piao, Byeong Hwa Jeon, Sang-Ha Oh, Cuk-Seong Kim
Summary: Keloid fibroblasts exhibit higher levels of cell proliferation, migration, collagen production, and TGF-beta signaling compared to normal fibroblasts, while CRIF1 deficiency inhibits these processes in both cell types. CRIF1 may regulate collagen production in keloids by modulating the TGF-beta/Smad pathway, suggesting it as a potential therapeutic target for keloid pathogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Tsung-Teng Huang, Chuan-Mu Chen, Lih-Geeng Chen, Ying-Wei Lan, Tse-Hung Huang, Kong Bung Choo, Kowit-Yu Chong
Summary: This study demonstrates that 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-Glucoside (THSG) can attenuate lung fibrosis and reduce lung injury by regulating multiple signaling pathways. THSG affects extracellular matrix deposition, fibronectin expression, oxidative stress, and autophagy. Therefore, THSG may be a potential drug for the treatment of pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Je-Oh Lim, Woong-Il Kim, Se-Jin Lee, So-Won Pak, Young-Kwon Cho, Jong-Choon Kim, Joong-Sun Kim, In-Sik Shin
Summary: The study shows that melatonin can alleviate inflammatory responses and worsening of lung function in COPD patients, possibly by inhibiting the expression of PDE4.
Article
Pharmacology & Pharmacy
Jiangcheng Shu, Lizhi Hu, Yichen Wu, Long Chen, Kai Huang, Zhaohui Wang, Minglu Liang
Summary: This study reveals that daidzein has an anti-fibrotic effect in myocardial fibrosis by reducing the activation of cardiac fibroblasts induced by TGF-beta 1, partially through regulating the TGF-beta 1/SMAD2/3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Mervat Z. Mohamed, Mohamed F. Abed El Baky, Merhan E. Ali, Heba M. Hafez
Summary: Aprepitant can prevent bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/p-Smad3 fibrotic pathway, and its therapeutic effect in improving lung damage and anti-fibrotic impact increases with the duration of treatment.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wang
Summary: This study found that astaxanthin can attenuate DNA damage and apoptosis caused by cigarette smoke, and reduce the activation of Caspase-3. Astaxanthin can also decrease the production of intracellular reactive oxygen species by suppressing the expression of NOX4 and DUOX1.
BIOMEDICINE & PHARMACOTHERAPY
(2023)