Article
Biochemistry & Molecular Biology
Annabelle Rosa, Elke Butt, Christopher P. Hopper, Stefan Loroch, Markus Bender, Harald Schulze, Albert Sickmann, Sandra Vorlova, Peter Seizer, David Heinzmann, Alma Zernecke
Summary: Cyclophilin A (CyPA) is a widely expressed protein in both prokaryotic and eukaryotic cells. Recent studies have suggested the possibility of acetylation at certain sites in CyPA. In this study, the researchers investigated whether acetylation at these sites plays a role in the release of CyPA from platelets. The results confirmed the presence of CyPA in platelets and its release upon stimulation, but no acetylation was observed. These findings suggest that acetylation is not a major protein modification in platelets and is not required for the release of CyPA from platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jang Mi Han, Hye Jin Jung
Summary: The interaction between Cyclophilin A and CD147 plays a crucial role in multiple diseases, particularly in the progression of cancer. Their overexpression is associated with cancer cell growth, metastasis, therapeutic resistance, and stem cell-like properties, leading to poor prognosis in cancer patients. Therefore, targeting the Cyclophilin A/CD147 interaction may improve treatment outcomes for cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Minami Sakamoto, Tomomitsu Miyagaki, Hiroaki Kamijo, Tomonori Oka, Hikari Boki, Naomi Takahashi-Shishido, Hiraku Suga, Makoto Sugaya, Shinichi Sato
Summary: CD147 and CypA are overexpressed in tumor cells of mycosis fungoides and Sezary syndrome patients, and CypA is also expressed by epidermal keratinocytes in lesional skin. Serum CypA levels are elevated and correlated with disease severity markers. Anti-CD147 and/or anti-CypA antibodies can suppress the proliferation of CTCL cell lines by downregulating signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Rezvan Asgari, Asad Vaisi-Raygani, Mohammad Sajad Emami Aleagha, Pantea Mohammadi, Mitra Bakhtiari, Nahid Arghiani
Summary: CD147 and MMPs play crucial roles in both physiological and pathological processes, and any dysregulation in their expression, synthesis, or function may be associated with various diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Lourdes Chulia-Peris, Cristina Carreres-Rey, Marta Gabasa, Jordi Alcaraz, Julian Carretero, Javier Pereda
Summary: Pulmonary fibrosis is a disease characterized by abnormal extracellular matrix deposition, fibroblast to myofibroblast transition, and parenchymal disorganization. The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is disrupted in pulmonary fibrosis. CD147, in addition to inducing MMP activity, also plays a key role in fibroblast to myofibroblast transition in this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jang Mi Han, Jae Kyung Sohng, Woo-Haeng Lee, Tae-Jin Oh, Hye Jin Jung
Summary: The novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin, exhibits potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma cells. Compound 9 targets cyclophilin A (CypA) and downregulates CD147-mediated MAPK signaling pathway, resulting in suppression of gastric cancer cell proliferation, migration, invasion, and angiogenesis. The interaction between compound 9 and CypA was confirmed through various assays, providing a new molecular basis for inhibiting gastric cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jing Liu, Ying Zuo, Gui-Mei Qu, Xiao Song, Zhong-Hui Liu, Ting-Guo Zhang, Zhu-Hua Zheng, Hong-Kun Wang
Summary: The study found that CypB is upregulated in endometrial cancer, and inhibiting CypB expression can significantly suppress cell proliferation, metastasis, and migration. Gene ontology and KEGG pathway enrichment analysis indicated that genes related to CypB are mainly enriched in cell cycle, glycosphingolipid biosynthesis, adherens junctions, and metabolism pathways.
Article
Biochemistry & Molecular Biology
Jiejie Geng, Liang Chen, Yufeng Yuan, Ke Wang, Youchun Wang, Chuan Qin, Guizhen Wu, Ruo Chen, Zheng Zhang, Ding Wei, Peng Du, Jun Zhang, Peng Lin, Kui Zhang, Yongqiang Deng, Ke Xu, Jiangning Liu, Xiuxuan Sun, Ting Guo, Xu Yang, Jiao Wu, Jianli Jiang, Ling Li, Kun Zhang, Zhe Wang, Jing Zhang, Qingguo Yan, Hua Zhu, Zhaohui Zheng, Jinlin Miao, Xianghui Fu, Fengfan Yang, Xiaochun Chen, Hao Tang, Yang Zhang, Ying Shi, Yumeng Zhu, Zhuo Pei, Fei Huo, Xue Liang, Yatao Wang, Qingyi Wang, Wen Xie, Yirong Li, Mingyan Shi, Huijie Bian, Ping Zhu, Zhi-Nan Chen
Summary: SARS-CoV-2 mutations increase viral transmissibility and immune escape, requiring in-depth investigation on COVID-19 pathogenesis for strategy development. CD147 is identified as a universal receptor for SARS-CoV-2 and its variants, and Meplazeumab effectively inhibits viral entry and inflammation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lixia Lu, Jianglin Zhang, Pingping Gan, Lisha Wu, Xu Zhang, Cong Peng, Jianda Zhou, Xiang Chen, Juan Su
Summary: Melanoma is an aggressive form of skin cancer characterized by rapid invasion and metastasis. In this study, it was found that CD147 translocates from the cell membrane to the mitochondria in advanced melanoma, where it can promote mitochondrial aerobic oxidation and the invasive abilities of melanoma cells by interacting with HSP60. The presence of mitochondrial CD147 was also associated with worse prognosis in melanoma patients, highlighting its potential as a therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Coralie Reger de Moura, Alexandra Landras, Farah Khayati, Uwe Maskos, Kamel Maouche, Maxime Battistella, Suzanne Menashi, Celeste Lebbe, Samia Mourah
Summary: Melanoma is a highly aggressive skin cancer that often metastasizes to the lymph nodes early and develops resistance to therapies. Understanding the mechanisms contributing to lymphangiogenesis and lymphatic vessel formation is crucial for treating metastatic cancer. The transmembrane glycoprotein CD147 plays a significant role in melanoma-associated lymphangiogenesis, making it a promising target for inhibition.
Article
Biochemistry & Molecular Biology
Cheng-Gong Liao, Xiao-Hua Liang, Yuan Ke, Li Yao, Man Liu, Ze-Kun Liu, Lin He, Yi-Xiao Guo, Huijie Bian, Zhi-Nan Chen, Ling-Min Kong
Summary: This study reveals that active demethylation of CD147 is involved in the metastasis of non-small cell lung cancer (NSCLC), and targeted methylation of CD147 can inhibit the invasion and metastasis of NSCLC, providing a promising therapeutic target for NSCLC.
Article
Ophthalmology
Meng-Lin Shi, Yu-Fen Chen, Wei-Qi Wu, Yao Lai, Qi Jin, Wan-Lu Qiu, Dong-Lian Yu, Yi-Zhong Li, Hong-Fei Liao
Summary: Luteolin has inhibitory effects on choroidal melanoma cells and acts through the PI3K/Akt signaling pathway. This study provides a new theoretical basis for the potential use of luteolin as a therapeutic medication for choroidal melanoma.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hee Jeong Cho, Hye Jin Jung
Summary: This study found that compound 9 and cyclosporin A are natural inhibitors of cyclophilin A (CypA), which can effectively suppress the growth of gastric cancer stem cells (GCSCs) by inducing cell cycle arrest, promoting apoptosis, and regulating AKT and MAPK signaling pathways through the inhibition of CypA/CD147 axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jang Mi Han, Sung Min Kim, Hong Lae Kim, Hee Jeong Cho, Hye Jin Jung
Summary: Non-small cell lung cancer (NSCLC) is a fatal malignant tumor, and cancer stem cells (CSCs) play crucial roles in its progression. In this study, the effects of natural cyclophilin A (CypA) inhibitors, C9 and CsA, on NSCLC CSCs were evaluated. Both compounds effectively suppressed the growth and self-renewal ability of NSCLC CSCs. They also activated the intrinsic apoptotic pathway and downregulated the expression levels of CSC markers through dual modulation of the CypA/CD147 axis and EGFR activity. Combined treatment with C9 or CsA and the EGFR tyrosine kinase inhibitor afatinib showed enhanced inhibition of EGFR-mutant NSCLC CSCs. These findings suggest that C9 and CsA have potential as anticancer agents to target EGFR-mutant NSCLC CSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ewelina Madej, Damian Ryszawy, Anna A. Brozyna, Malgorzata Czyz, Jaroslaw Czyz, Agnieszka Wolnicka-Glubisz
Summary: RIPK4 expression in melanoma is heterogeneous, with higher levels in metastatic melanoma cell lines. Down-regulating RIPK4 reduces invasive potential and pro-invasive protein levels, while PMA treatment leads to RIPK4 degradation and cell migration control via NF-kappa B signaling in a RIPK4-dependent or independent manner depending on cell origin and phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
