期刊
ONCOTARGET
卷 8, 期 15, 页码 25806-25813出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15709
关键词
cyclophilin A; CD147; melanoma; cell proliferation; MMPs
资金
- National Natural Science Foundation of China [81472882]
- National Science Fund for Distinguished Young Scholars [81225013]
- Natural Science Foundation of Hunan [11JJ5083]
- Young Talents Support Plan of Hunan, P. R. China
CD147/basigin, a transmembrane protein, is a member of the immunoglobulin super family. Accumulating evidence has revealed the role of CD147 in the development and progression of various cancers, including malignant melanoma (MM). MM is a malignancy of pigment-producing cells that causes the greatest number of skin cancer-related deaths worldwide. CD147 is overexpressed in MM and plays an important role in cell viability, apoptosis, proliferation, invasion, and metastasis, probably by mediating vascular endothelial growth factor (VEGF) production, glycolysis, and multi-drug resistance (MDR). As a matrix metalloproteinase (MMP) inducer, CD147 could also promote surrounding fibroblasts to secrete abundant MMPs to further stimulate tumor cell invasion. Targeting CD147 has been shown to suppress MM in vitro and in vivo, highlighting the therapeutic potential of CD147 silencing in MM treatment. In this review article, we discuss CD147 and its biological roles, regulatory mechanisms, and potential application as a molecular target for MM.
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