Article
Oncology
Yuying Xiang, Feiyu Shan, Guan Feng, Kaibo Guo, Shanming Ruan, Dawei Huang
Summary: This study explored the prognostic value of mRNA expression of the 4.1 family in non-small cell lung cancer (NSCLC). Different members of the 4.1 family were found to be associated with various survival outcomes in different types of NSCLC. Additionally, factors such as gender, smoking status, and tumor stage also influenced the impact of 4.1 family members on patient prognosis.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Reproductive Biology
Quan Zhou, Huai-Jie Yang, Man-Zhen Zuo, Ya-Ling Tao
Summary: This study investigated the expression patterns and prognostic value of the GATA family in human ovarian cancer. The results showed that different members of the GATA family were associated with different clinical outcomes and molecular characteristics of ovarian cancer, suggesting their potential as prognostic markers and therapeutic targets.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
He-Wei Zhang, Ying Guo, Lin-xiao Sun, Fu-biao Ni, Ke Xu
Summary: The study found that high expression of three members of SMADs (SMAD1, SMAD2, SMAD4) is associated with favorable overall survival of gastric cancer patients, while the expression level of SMAD3 indicates highly differentiated cancer. Surgical treatment is associated with high expression levels of SMAD1 and SMAD2, and the effect of Her2 on gastric cancer is not significant. Furthermore, inhibition of SMAD3 expression suppressed the proliferation and migration ability of gastric cancer cells through inducing apoptosis.
Article
Oncology
Xi Zhang, Xin Mu, Ou Huang, Jialin Chen, Debo Chen
Summary: This study investigated the prognostic value of EphA receptor expression in breast cancer patients, and found that certain EphA receptors were correlated with better relapse-free survival while others were associated with a worse outcome.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2021)
Article
Oncology
Wenxiao Jiang, Mandika Chetry, Shuya Pan, Longyi Wang, Xueqiong Zhu
Summary: The study found that LGALS10 may be a valuable biomarker for predicting a favorable prognosis in patients with ovarian cancer, especially in those with serous, all stages, and grade III cancer.
Article
Genetics & Heredity
Zong-Qing Zheng, Guo-Guo Zhang, Gui-Qiang Yuan, Jia-Hui Hao, Qian-Qian Nie, Ming-Cheng Zheng, Zhong Wang
Summary: Notch receptors play critical clinical roles in primary glioblastoma, with Notch3 receptor serving as a practical tool for predicting patient survival and being associated with immune cell infiltration and tumor proliferation.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Jing Yu, Lei Nie, Dongde Wu, Jian Chen, Zhifeng Yang, Ling Zhang, Dongqing Li, Xia Zhou
Summary: A clinical biochemistry-based nomogram was developed to predict the progression of COVID-19, with CEA, WBC, CRP, PCT, Fer, D-dimer, Neu%, and L% identified as independent prognostic factors. The nomogram constructed using these biomarkers offers guidance for the diagnosis and treatment of COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Birhanu Aberha Berele, Yuxiang Cai, Guifang Yang
Summary: Tumor infiltrating lymphocytes (TILs) in NPC patients have prognostic value, with different lymphocytic subtypes and microanatomic locations affecting the outcome. Further large-scale studies are needed to confirm the prognostic value of TILs in different microanatomic locations.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Chemistry, Multidisciplinary
Longfei Jia, Shu-Bing Qian
Summary: Synthetic mRNA has emerged as a programmable therapeutic reagent, offering advantages in flexible design, low-cost preparation, and potential for various therapeutic applications. Recent advancements in mRNA technology have led to successful development of mRNA vaccines against SARS-CoV-2, highlighting the importance of understanding mRNA metabolism and translational control. However, challenges remain in the rational design of synthetic mRNAs for optimal stability and translation efficiency.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Aravind Lathika Rajendrakumar, Simona M. Hapca, Anand Thakarakkattil Narayanan Nair, Yu Huang, Mehul Kumar Chourasia, Ryan Shun-Yuen Kwan, Charvi Nangia, Moneeza K. Siddiqui, Prathiba Vijayaraghavan, Shona Z. Matthew, Graham P. Leese, Viswanathan Mohan, Ewan R. Pearson, Alexander S. F. Doney, Colin N. A. Palmer
Summary: This study found an association between neutrophil-lymphocyte ratio (NLR) and the incidence of diabetic retinopathy (DR) in the Scottish population. A specific NLR value can predict the occurrence of retinopathy. The study suggests that NLR has a potential predictive value for DR incidence in the Scottish population, especially in individuals under 65 years old and those with well-controlled diabetes.
Article
Chemistry, Analytical
Liang Dong, Chung-Ying Huang, Eric J. Johnson, Lei Yang, Richard C. Zieren, Kengo Horie, Chi-Ju Kim, Sarah Warren, Sarah R. Amend, Wei Xue, Kenneth J. Pienta
Summary: Extracellular vesicles (EVs) are important players in intercellular communication, with mRNA transcripts in EVs potentially contributing to cancer progression. The cargo of EVs is not completely reflective of their cell origin, indicating a complex mechanism of cargo sorting that requires further elucidation.
ANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Haohao Han, Yifang Yao, Hong Wang, Meng Zhou, Ziyan Zhang, Xiaoyan Xu, Jiaqian Qi, Yuejun Liu, Depei Wu, Yue Han
Summary: This study suggests that NOTCH mutations (NOTCHmut) may serve as an indicator for poor prognosis of acute myeloid leukemia (AML). NOTCHmut is associated with low platelet count and coexistence with other mutations. The presence of NOTCHmut is correlated with worse overall survival and relapse-free survival, especially within the intermediate-risk group according to the European Leukemia Net 2017 classification.
Article
Medicine, Research & Experimental
Yibing Hu, Jin Ding, Yanping Chen, Xiaohua Ye
Summary: The study found that higher levels of HMGB1, HMGB2, and HMGB3 mRNA were significantly associated with better overall survival in GC patients. The mRNA levels of some HMGB members were significantly correlated with clinical characteristics of patients, revealing novel prognostic roles for HMGB proteins in GC.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Yongdong Guo, Xiaoping Dong, Jing Jin, Yutong He
Summary: Increasing evidence supports the crucial role of proteasome activator subunit (PSME) genes in various tumors. In gastric cancer (GC), PSME genes show diverse expression patterns and potential prognostic value, with PSME1 and PSME2 up-regulation correlating with better survival outcomes. High PSME1 and PSME2 expression in GC patients is associated with enhanced anti-cancer immunity and potential response to immunotherapy, while PSME3 may act as an oncogene and PSME4 shows promise as a diagnostic indicator for GC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Faezeh Jame-Chenarboo, Hoi Hei Ng, Dawn Macdonald, Lara K. Mahal
Summary: Chemical biology has revealed the significance of sialic acids as important signals in physiology and disease. miRNAs, noncoding RNAs that downregulate protein expression, have been shown to play a role in regulating glycosylation. Contrary to expectations, our study found that the majority of miRNAs upregulate ST6GAL1 and alpha-2,6-sialylation in cancer cells, while miRNAs that regulate ST6GAL2 were predominantly downregulatory. This challenges previous assumptions about miRNA and suggests a potential pathway for explaining the dysregulation of sialylation observed in cancer and other diseases.
ACS CENTRAL SCIENCE
(2022)
