Journal
ONCOTARGET
Volume 8, Issue 22, Pages 36787-36799Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16375
Keywords
non-coding RNA; non-small cell lung cancer; microRNA; long-coding RNA; epithelial-mesenchymal transition
Categories
Funding
- National Natural Science Foundation of China [81172335, 81472266]
- Excellent Youth Foundation of Jiangsu Province, China [BK20140032]
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Non-small cell lung cancer (NSCLC) remains a major health problem that patients suffer from around the world. The epithelial to mesenchymal transition (EMT) has attractive roles in increasing malignant potential and reducing sensitivity to conventional therapeutics in NSCLC cells. Meanwhile, it is now evident that non-coding RNAs (ncRNAs), primarily microRNAs and long non-coding RNAs contribute to tumorigenesis partially via regulating EMT. This article briefly summarizes current researches about EMT-related ncRNAs in NSCLC and discusses their crucial roles in the complex regulatory network. Also, the authors will show the evidence that ncRNAs not only contribute to cancer cells migration and invasion, but also take charge of the resistance of chemotherapy, radiotherapy and EGFR-TIKs. Then, we will further discuss the potential of inhibition of EMT via manipulating relevant ncRNAs to change our current treatment of NSCLC patients.
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