Article
Biotechnology & Applied Microbiology
Chuming Tao, Haitao Luo, Luyue Chen, Jingying Li, Xingen Zhu, Kai Huang
Summary: This study identified a nine-EMT-related lncRNA signature with prognostic value in gliomas, showing that patients in the low-risk group had longer survival and were associated with specific genetic characteristics. The findings were validated in different genomic datasets. The lncRNA-mediated ceRNA network may play a potential role in EMT progression in gliomas.
Review
Biochemistry & Molecular Biology
Kenji Takahashi, Kenzui Taniue, Yusuke Ono, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura
Summary: ncRNAs, including small and long ncRNAs, are involved in the pathogenesis of various diseases, with some being encapsulated in extracellular vesicles and transferred to recipient cells to regulate cellular processes. Studies have uncovered the molecular mechanisms and functions of lncRNAs in PDAC, providing insights into their roles in EMT and tumor cell stemness. Dysregulated expression of lncRNAs and the potential contribution of lncRNAs and EVs in PDAC pathogenesis have been highlighted.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Xuexue Xu, Yuling Wang, Ziqing Zhou, Dongxu Jiang, Shen Shen, Yong Ding, Yong Zhou, Ran Zhuang
Summary: Our study revealed that knockdown of HuR suppresses OS cell EMT by regulating the lncRNA XIST/AGO2 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhikun Chen, Qin Che, Chunxue Xie
Summary: The study revealed that NORAD is significantly upregulated in lung cancer tissues and cells, promoting cell migration and invasion. miR-422a, predicted as a target of NORAD, shows lower expression levels in lung cancer tissues compared to healthy tissues. This suggests that NORAD regulates lung cancer cell EMT through miR-422a, presenting a potential therapeutic target for NSCLC development intervention.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Jinqin Chen, Chengpeng Gao, Wei Zhu
Summary: SLC25A25-AS1 exerts tumor-promoting roles in non-small cell lung cancer (NSCLC) by controlling the miR-195-5p/ITGA2 axis. High expression of SLC25A25-AS1 is significantly associated with shorter overall survival time in NSCLC patients, and its silencing can inhibit malignant behaviors of NSCLC cells.
Article
Cell Biology
Lang Xiong, Yan Sun, Jingqi Huang, Pengjuan Ma, Xiaoran Wang, Jiani Wang, Baoxin Chen, Jieping Chen, Mi Huang, Shan Huang, Yizhi Liu
Summary: This study reveals the regulatory mechanism of lncRNA H19 in lens fibrosis. The researchers found that H19 was highly expressed in lens epithelial cells but downregulated after exposure to TGF-beta 2. Silencing H19 exacerbated TGF-beta 2-induced EMT, while overexpressing H19 partially reversed EMT. In vitro and in vivo experiments confirmed the important role of H19 in maintaining lens clarity.
Article
Endocrinology & Metabolism
Y. C. Zhao, Y. Li
Summary: The study reveals that SNHG7 promotes invasion, migration, and EMT of OC cells by targeting EDG4 through miR-34a and activating the PI3K/AKT pathway. Therefore, the downregulation of SNHG7 can inhibit EMT in OC cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Multidisciplinary Sciences
Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Soumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O'Keefe, Michela Garofalo
Summary: This study reveals the role of KIMAT1 in maintaining KRAS signaling in lung cancer progression, suggesting that targeting it may be a strategy to prevent KRAS-induced tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Article
Medicine, General & Internal
Shenglan Huang, Dan Li, Lingling Zhuang, Jian Zhang, Jianbing Wu
Summary: A novel EMT-related lncRNA risk signature, including 12 lncRNAs, has been established and identified in patients with HCC, which accurately predicts the prognosis of HCC patients and may be used to guide individualized treatment in clinical practice.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Milad Ashrafizadeh, Md Shahinozzaman, Sima Orouei, Vahideh Zarrin, Kiavash Hushmandi, Farid Hashemi, Anuj Kumar, Saeed Samarghandian, Masoud Najafi, Ali Zarrabi
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in regulating epithelial-to-mesenchymal transition (EMT) in lung cancer. Some lncRNAs have tumor-suppressing effects by inhibiting EMT and metastasis, while others have tumor-promoting effects by triggering EMT and enhancing migration of cancer cells. Targeting lncRNAs could be important in controlling the migration of lung cancer cells.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Oncology
Jara Martin, Joan Josep Castellano, Ramon Maria Marrades, Jordi Canals, Nuria Vinolas, Tania Diaz, Laureano Molins, Daniel Martinez, Bing Han, Jorge Moises, Yangyi He, Mariano Monzo, Alfons Navarro
Summary: Circ-10720 regulates EMT, apoptosis, and proliferation in non-small cell lung cancer and acts as a biomarker for relapse.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Cell Biology
Carmen Lanzillotti, Monica De Mattei, Chiara Mazziotta, Francesca Taraballi, John Charles Rotondo, Mauro Tognon, Fernanda Martini
Summary: Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in osteogenesis, regulating molecular pathways and influencing bone growth and development through their interactions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Sandra Ortiz-Cuaran, Aurelie Swalduz, Jean-Philippe Foy, Solene Marteau, Anne-Pierre Morel, Frederique Fauvet, Genevieve De Souza, Lucas Michon, Maxime Boussageon, Nicolas Gadot, Marion Godefroy, Sophie Leon, Antonin Tortereau, Nour-El-Houda Mourksi, Camille Leonce, Marie Alexandra Albaret, Anushka Dongre, Beatrice Vanbervliet, Marie Robert, Laurie Tonon, Roxane M. Pommier, Veronique Hofman, Valery Attignonf, Sandrine Boyaulta, Carole Audoynaud, Jessie Auclairf, Fanny Bouquetg, Qing Wang, Christine Menetrier-Cauxa, Maurice Perolb, Christophe Cauxa, Paul Hofmand, Sylvie Lantuejoulb, Alain Puisieuxa, Pierre Saintigny
Summary: Epithelial-to-mesenchymal transition (EMT) is associated with tumor aggressiveness, drug resistance, and poor survival in non-small cell lung cancer (NSCLC) and other cancers. Researchers have found that CD70 and ZEB1 play a key role in immune escape in NSCLC, providing new insights for treating NSCLC through immunotherapy strategies.
EUROPEAN JOURNAL OF CANCER
(2022)
