Article
Cell Biology
Chunlei Guo, Shuang Li, Ang Liang, Mengchao Cui, Yunwei Lou, Hui Wang
Summary: PPA1 is highly expressed in breast cancer and correlated with poor survival in patients. Silencing PPA1 can inhibit breast cancer proliferation and metastasis. PPA1 serves as an activator of the PI3K/AKT/GSK3 beta/Slug-mediated breast cancer progression and is a potential therapeutic target for inhibiting tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Weipu Mao, Keyi Wang, Si Sun, Jianping Wu, Ming Chen, Jiang Geng, Ming Luo
Summary: The study revealed that ID2 serves as a tumor suppressor in bladder cancer, with high ID2 expression associated with lower tumor staging and better survival rates. Mechanistically, ID2 inhibits the progression and metastasis of BCa through the PI3K/AKT signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Chaoyang Zhou, Aijun Liang, Jianzhong Zhang, Jingxing Leng, Bin Xi, Bin Zhou, Yu Yang, Ronglan Zhu, Liangchen Zhong, Xingxing Jiang, Dengfeng Wan
Summary: ANTXR1 plays a crucial role in glioma tumorigenesis by regulating cell proliferation through activating the PI3K/AKT pathway, affecting cell growth, migration, apoptosis, and the cell cycle. Targeting ANTXR1 could serve as a molecular target in clinical therapeutics for gliomas.
Article
Biochemistry & Molecular Biology
Junlong Zhu, Hang Tong, Yan Sun, Tinghao Li, Guang Yang, Weiyang He
Summary: N6-methyladenosine (m6A) is a common mRNA modification that plays a critical role in tumor progression, prognoses, and therapeutic response. This study focuses on the role of m6A modifications in bladder carcinogenesis and development and investigates the association between METTL3/YTHDF1 and bladder cancer cell proliferation and cisplatin resistance. The results show that reduced expression of METTL3/YTHDF1 leads to decreased bladder cancer cell proliferation and cisplatin sensitivity, while overexpression of the downstream target gene, RPN2, can rescue this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shan Zhu, Wenhui Jiao, Yanglu Xu, Lanjiao Hou, Hui Li, Jingrong Shao, Xiaoliang Zhang, Ran Wang, Dexin Kong
Summary: This study demonstrated the anti-proliferative and anti-metastatic activities of palmitic acid on human prostate cancer cells, potentially through targeting the PI3K/Akt pathway.
Article
Oncology
Xueyi Jiang, Jie Wang, Peng Chen, Zhiwei He, Jian Xu, Yankun Chen, Xinyuan Liu, Jianxin Jiang
Summary: The study found that 6-P can suppress the proliferation and metastasis of pancreatic cancer cells by decreasing EGFR protein expression level and inducing EGFR degradation, leading to inactivation of the PI3K/AKT signaling pathway. Additionally, ectopic expression of EGFR protein results in resistance to the therapeutic effects of 6-P. Furthermore, erlotinib can enhance the anticancer activity of 6-P.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Changyuan Kang, Lizhou Jia, Lei Hao, Ning Zhang, Yang Liu, Lingli Zhang
Summary: POM121 is overexpressed in gastric cancer tissues compared to normal gastric tissues and is associated with deep invasion, distant metastases, and TNM stage in gastric cancer patients. POM121 promotes proliferation, migration, and invasion of gastric cancer cells through the phosphorylation of the PI3K/AKT pathway and increased expression of MYC. These findings suggest that POM121 may serve as an independent prognostic factor for gastric cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yue Wang, Ying Li, Liang Wang, Buze Chen, Miaolin Zhu, Chunyi Ma, Chunyan Mu, Aibin Tao, Shibao Li, Lan Luo, Ping Ma, Shuai Ji, Ting Lan
Summary: In this study, it was found that cinnamaldehyde (CA) inhibits the proliferation and invasion ability of ovarian cancer cells and plays a role in promoting apoptosis and inhibiting the PI3K/AKT signaling pathway. Additionally, CA also inhibits the EGF-induced EMT process. In vivo experiments showed significant repression of ovarian cancer progression and metastasis by CA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Feikai Lin, Jieru Zhou, Xiaoduan Li, Xipeng Wang
Summary: The study found that NOL4L is highly expressed in tumor tissues, especially in peritoneal metastatic tissues, and is associated with prognosis in ovarian cancer patients. Results showed that NOL4L promotes proliferation and metastasis of ovarian cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jia-cheng Xu, Tian-yin Chen, Le-tai Liao, Tao Chen, Quan-lin Li, Jia-xin Xu, Jian-wei Hu, Ping-hong Zhou, Yi-qun Zhang
Summary: Our study revealed that high expression of NETO2 in ESCC patients was associated with tumor staging and lymph node metastasis, promoting ESCC progression through enhancing cell proliferation, suppressing apoptosis, and stimulating tumor growth. Additionally, NETO2 was found to play a crucial role in regulating migration, invasion, and epithelial-mesenchymal transition in ESCC cells. Mechanistically, NETO2 activated ERK, PI3k/AKT, and Nrf2 signaling pathways, with Nrf2 identified as a critical downstream mediator responsible for tumorigenesis. This suggests that NETO2 may serve as a potential therapeutic target or prognostic biomarker for ESCC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: The study found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the growth and proliferation of lung cancer cells by enhancing mitochondrial fusion and oxidative phosphorylation pathway.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Liwei Wang, Jiazhong Shi, Sha Liu, Yaqin Huang, Hua Ding, Baixiong Zhao, Yuting Liu, Wuxing Wang, Jin Yang, Zhiwen Chen
Summary: The study found that RAC3 is highly expressed in bladder cancer and is associated with poor prognosis. Silencing RAC3 can exert anti-tumor effects by enhancing PI3K/AKT/mTOR-mediated autophagy. Simultaneously targeting RAC3 and autophagy may be a potential therapeutic strategy for inhibiting bladder cancer progression and prolonging survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Tao Xu, Ting Rao, Wei-Ming Yu, Jin-Zhuo Ning, Xi Yu, Shao-Ming Zhu, Kang Yang, Tao Bai, Fan Cheng
Summary: The study revealed that NFKBIZ has low expression in bladder cancer and inhibits the proliferation of bladder cancer cells through the PTEN/PI3K/Akt signaling pathway. This suggests that NFKBIZ may serve as a novel prognostic biomarker and potential therapeutic target for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Qinghua Wang, Zelin Liu, Guanzhong Zhai, Xi Yu, Shuai Ke, Haoren Shao, Jia Guo
Summary: This study found that GATA5 is downregulated in prostate cancer, and its downregulation is associated with tumor proliferation, migration, invasion, and the process of epithelial-mesenchymal transition (EMT). In addition, GATA5 can interact with PLAGL2 to regulate prostate cancer cell growth through the FAK/PI3K/AKT signaling pathway.
Article
Biochemistry & Molecular Biology
Hualin Chen, Lin Ma, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: POLR3G is highly expressed in bladder cancer and is associated with poor prognosis. Its deficiency inhibits migration and invasion of bladder cancer cells and reduces the expression of EMT-related markers. Mechanistically, POLR3G can promote EMT in bladder cancer by activating the PI3K/AKT signaling pathway.