The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

(2017) ffolliott M. Fisher et al.   Molecular Metabolism

FGF21 Regulates Sweet and Alcohol Preference

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

(2016) Stephanie von Holstein-Rathlou et al.   Cell Metabolism

Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology

(2016) Lea M.D. Delbridge et al.   DIABETES

Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes

(2016) Tauseef A. Khan et al.   EUROPEAN JOURNAL OF NUTRITION

A review of recent evidence relating to sugars, insulin resistance and diabetes

(2016) I. A. Macdonald   EUROPEAN JOURNAL OF NUTRITION

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP)

(2016) Shogo Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

A new frontier in FGF21 biology

(2016) Matthew J. Potthoff   Nature Reviews Endocrinology

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis

(2016) Mark A. Herman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diabetes regulates fructose absorption through thioredoxin-interacting protein

(2016) James R Dotimas et al.   eLife

Keeping tabs on fructose

(2016) Anath Shalev   eLife

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop

(2016) Gu Jing et al.   Molecular Metabolism

Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK

(2015) Chirag Patel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

(2015) Wudelehu Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin

(2015) Naravat Poungvarin et al.   ENDOCRINOLOGY

Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption

(2015) Chirag Patel et al.   FASEB JOURNAL

Is fructose malabsorption a cause of irritable bowel syndrome?

(2015) James J. DiNicolantonio et al.   MEDICAL HYPOTHESES

Fructose ingestion acutely stimulates circulating FGF21 levels in humans

(2015) Jody R. Dushay et al.   Molecular Metabolism

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

Feedback looping between ChREBP and PPAR^|^alpha; in the regulation of lipid metabolism in brown adipose tissues

(2013) Katsumi Iizuka et al.   ENDOCRINE JOURNAL

A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome

(2013) Emma P. Halmos et al.   GASTROENTEROLOGY

Metabolite Regulation of Nucleo-cytosolic Trafficking of Carbohydrate Response Element-binding Protein (ChREBP)

(2013) Tsutomu Nakagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel insights into ChREBP regulation and function

(2013) Gaëlle Filhoulaud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes

(2012) Catherine Arden et al.   BIOCHEMICAL JOURNAL

Role of glucose-6-phosphate and xylulose-5-phosphate in the regulation of glucose-stimulated gene expression in the pancreatic ^|^beta; cell line, INS-1E

(2012) Katsumi Iizuka et al.   ENDOCRINE JOURNAL

The role of fructose transporters in diseases linked to excessive fructose intake

(2012) Veronique Douard et al.   JOURNAL OF PHYSIOLOGY-LONDON

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Fructose metabolism in humans – what isotopic tracer studies tell us

(2012) Sam Z Sun et al.   Nutrition & Metabolism

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver

(2012) Miguel A. Lanaspa et al.   PLoS One

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

(2012) Yukari Ido-Kitamura et al.   PLoS One

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice

(2012) T. Ishimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rat glucagon receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate response element binding protein

(2011) Katsumi Iizuka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fructose Malabsorption and Intolerance: Effects of Fructose with and without Simultaneous Glucose Ingestion

(2011) Marie E. Latulippe et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver

(2011) Renaud Dentin et al.   JOURNAL OF HEPATOLOGY

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression

(2011) Yun-Seung Jeong et al.   PLoS One

Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)

(2010) Ming V. Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eucalyptus Leaf Extract Suppresses the Postprandial Elevation of Portal, Cardiac and Peripheral Fructose Concentrations after Sucrose Ingestion in Rats

(2010) Keiichiro Sugimoto et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer

(2010) C. W. Peterson et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic Effects of Fructose and the Worldwide Increase in Obesity

(2010) Luc Tappy et al.   PHYSIOLOGICAL REVIEWS

Fructose induced lipogenesis: from sugar to fat to insulin resistance

(2010) Varman T. Samuel   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

(2009) Katsumi Iizuka et al.   FEBS LETTERS

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

(2009) Christine P. Diggle et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Regulation of the fructose transporter GLUT5 in health and disease

(2008) Veronique Douard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension

(2008) Sharon Barone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY