Article
Environmental Sciences
Quan Mo, Muhammad Fakhar-e-Alam Kulyar, Yanmei Ding, Yan Zhang, Huachun Pan, Jiakui Li
Summary: This study examines the toxic effects of long-term exposure to Thiram on the heart of broilers and finds that Thiram may cause cardiotoxicity by interfering with taurine and hypotaurine metabolism, pyrimidine metabolism, and glycerolipid metabolism. This study is of great importance for understanding the molecular mechanism of cardiotoxicity caused by Thiram.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, General & Internal
Piyush Sharma, Raj Kumar Yadav, Rajesh Khadgawat, Rima Dada
Summary: This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care on the expression of genes related to oxidative stress, inflammation, and aging in obese adults. The results suggest a positive impact of yoga-based intervention on the expression of aging-related genes in obesity, although this benefit was not evident till week 12.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Tingjie Yang, Ke Wan, Rizhen Song, Xinli Guo, Yuanwei Xu, Jie Wang, Qing Zhang, Kevin Michael Alexander, Ronglih Liao, Yucheng Chen
Summary: This study demonstrated that low serum HDL-C may indicate a poor prognosis for patients with light-chain amyloid cardiomyopathy, affecting patients' survival time.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
E. L. Deters, S. L. Hansen
Summary: Transportation of cattle has negative impacts on animal health and production efficiency. This study investigated the physiological responses of beef steers to long-distance road transit and found that it resulted in reduced feed intake and body weight, increased oxidative stress and inflammation markers in the blood, elevated antioxidant enzyme activity in the muscle and liver, and altered abundance of proteins and metabolites related to energy metabolism. The findings highlight the important role of muscle in how cattle respond to and recover from transportation stress.
Article
Nutrition & Dietetics
Lindsey Miller, Kari Thompson, Carolina Pavlenco, Vijaya Saradhi Mettu, Hans Haverkamp, Samantha Skaufel, Abdul Basit, Bhagwat Prasad, Julie Larsen
Summary: Interventions to decrease inflammation and improve metabolic function may help prevent obesity-related diseases. This study investigated the effects of MSM supplementation on cardiometabolic health, inflammation, and oxidative status, and found that MSM supplementation led to increased levels of high-density lipoprotein cholesterol.
Article
Fisheries
Wei Wang, Yu Zhan, Lei Peng, Dongxu Gao, Yan Chen, Xue Zhuang
Summary: This study investigated the antioxidant and anti-inflammatory effects of artemisinin (ART) on juvenile fat greenling, as well as the associated metabolic pathways. The results showed that ART significantly increased body weight gain and improved tissue structure, and effectively attenuated oxidative stress and inflammatory responses. Liver metabolomics analysis revealed that ART alleviated inflammation and oxidative stress through lipid and amino acid metabolism pathways. In conclusion, ART has great potential as a natural feed additive against pathogen-induced oxidative stress and inflammation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Psychology, Biological
Nkazimulo Mnguni, Johanna Roche, Chloe Dafkin, Karine Scheuemaier
Summary: This study aimed to investigate the effects of intense or moderate aerobic exercise on sleep quality and quantity in overweight/obese young adults. The results showed that intense or moderate aerobic exercise does not have significant beneficial or adverse effects on sleep quality and quantity in young adults with overweight/obesity. Subjective appetite may have a relationship with REM and stage 2 sleep independent of exercise.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Clinical Neurology
Klaus Munkholm, Anne Sophie Jacoby, Maj Vinberg, Lars Vedel Kessing
Summary: This study investigated the relationship between plasma ferritin levels and bipolar disorder. The results showed that ferritin levels were higher in depressed patients with bipolar disorder and were associated with levels of inflammatory markers and markers of oxidative DNA and RNA damage. This suggests that iron metabolism may play a role in the pathophysiology of bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Zaidatul Akmal Othman, Zaida Zakaria, Joseph Bagi Suleiman, Khairul Mohd Fadzli Mustaffa, Nur Asyilla Che Jalil, Wan Syaheedah Wan Ghazali, Ninie Nadia Zulkipli, Mahaneem Mohamed
Summary: This study found that orlistat can mitigate myocardial damage in obese rats by improving oxidative stress, inhibiting inflammation and apoptosis. This is of great significance for understanding the pharmacological effects of orlistat and its application in treating complications related to obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tiziana Bacchetti, Camilla Morresi, Gianna Ferretti, Anders Larsson, Torbjoern Akerfeldt, Michael Svensson
Summary: This study aimed to investigate the effects of exercise on HDL composition and functional properties in overweight/obese subjects. The results showed that exercise training improved HDL functionality in overweight/obese adults, without significant reduction in BMI or modifications of glucose and lipid biochemical parameters. The study also found a significant correlation between serum MPO/PON ratios, HDL redox activity and ox-LDLs.
Article
Chemistry, Analytical
Manfei Xu, Yuebing Yue, Jie Huang
Summary: Alzheimer's disease (AD) is a progressive disease with continuous brain changes and has caused a severe burden on families and society. Huanglian Jiedu Decoction (HLJD) is a classic traditional Chinese medicine formula that can improve AD animals' cognitive impairment. This study recruited 50 AD patients who were divided into two groups, one receiving donepezil (DON) treatment and the other receiving DON + HLJD treatment for 3 months. The curative effect, inflammatory and oxidative stress levels were analyzed. HLJD combined with DON could improve the disease syndrome and inhibit inflammation and oxidative stress in AD.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Meagan S. Kingren, Marlene E. Starr, Hiroshi Saito
Summary: The incidence and mortality rates of sepsis increase significantly with age, especially in older adults. However, there is currently a lack of effective therapeutic strategies targeting older patients with severe sepsis, despite ongoing research efforts. Further research using aged animal models with clinically relevant treatments is essential for future progress in this area.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Environmental Sciences
Beate Ritz, Qi Yan, Di He, Jun Wu, Douglas Walker, Karan Uppal, Dean P. Jones, Julia E. Heck
Summary: This study investigated the metabolic effects of air pollution exposure during pregnancy on neonates and found that neonates exposed to air pollution exhibit alterations in oxidative stress and inflammation pathways related to lipid metabolism.
ENVIRONMENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Martha Lucinda Contreras-Zentella, Rolando Hernandez-Munoz
Summary: This article discusses the relationships among inflammatory events, oxidative stress, and metabolic alterations in patients with obesity and/or type 2 diabetes, as well as the influence of gender on these processes.
Article
Physiology
Yingyin Xu, Liyuan Xie, Jie Tang, Xiaolan He, Zhiyuan Zhang, Ying Chen, Jie Zhou, Bingcheng Gan, Weihong Peng
Summary: This study demonstrates that Morchella importuna polysaccharides can alleviate hepatic oxidative damage and inflammation induced by carbon tetrachloride in mice. MIPs show significant improvements in biochemical parameters and liver indicators under CCl4 intoxication, potentially exerting a protective effect by influencing metabolic pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Correction
Food Science & Technology
Humna Liaqat, Eunseon Jeong, Kyeong Jin Kim, Ji Yeon Kim
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Seunghee Kang, Eunok Lee, Heeyeon Lee, Geum-Sook Hwang, Jaekyung Lee, Ji Won Kim, Bumjo Oh, Ji Yeon Kim, Oran Kwon
Summary: The study found that supplementation with yellow yeast rice (YYR) significantly reduced total cholesterol, LDL, and apolipoprotein B100 levels in hypercholesterolemic subjects. YYR works by stimulating bile salt export pumps and inhibiting cholesterol biosynthesis, thus reducing intrahepatic cholesterol availability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Soo-yeon Park, Min Ju Park, Ji Yeon Kim
Summary: Cardiovascular diseases are a significant global cause of illness and death. Red foods, especially red fruits and vegetables, can protect heart and vascular health and reduce the risk of heart disease and stroke.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Heeyeon Joo, Jiyoung Hwang, Ji Yeon Kim, Saejong Park, Hyesook Kim, Oran Kwon
Summary: This study aimed to investigate whether carotenoids modify the association between plasma malondialdehyde (MDA) and physical performance in Korean adolescents. The results showed a negative association between plasma MDA levels and hand grip strength in male adolescents, and this association may be modified by plasma carotenoid levels.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Cheolgyun Park, Youjin Kim, Chanhee Lee, Ji Yeon Kim, Oran Kwon, Taesung Park
Summary: This study proposes a novel two-dimensional health space method based on scores of metabolic stress and oxidative stress. Through simulation and validation studies, the usefulness of the proposed method was demonstrated.
Article
Food Science & Technology
Ye Ji Hyun, Soo-yeon Park, Ji Yeon Kim
Summary: This study found that fermented rice germ extracts fermented with Lactobacillus plantarum inhibited glucose uptake by suppressing the expression of GLUT2 and SGLT1 mRNA. Experimental results demonstrated that this extract significantly reduced postprandial blood glucose levels, suggesting its potential in alleviating postprandial hyperglycemia in the gastrointestinal tract.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soo-yeon Park, Yong Dae Kim, Min Seo Kim, Ki-Tae Kim, Ji Yeon Kim
Summary: Cinnamon water extract (CWE) intake improved diarrhea symptoms and changed the composition of stools and gut microbiota. It increased colonic transit time and fecal isobutyric acid and spermidine contents, while decreasing fecal indole and agmatine contents. CWE also showed significant changes in strains of Bifidobacterium longum ATCC 55813 and increased alpha diversity in the gut microbiota.
Article
Food Science & Technology
Tae gwon Park, Yu Rim Kim, Soo-yeon Park, Kwanyong Choi, Kyeong Jin Kim, Ji Yeon Kim
Summary: The potential beneficial effects of Cinnamomum cassia on the intestine were evaluated in this study. It was found that cinnamon extract can improve intestinal health, alleviate inflammatory damage, and enhance tight junction function.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Young Park, Soo-yeon Park, Anita Hartog, Els van Hoffen, Alwine Kardinaal, Joohee Kim, Hee Jung Choi, Oran Kwon, Ji Yeon Kim
Summary: This study aims to develop a safe human challenge model to study gastrointestinal inflammation and immune function. It focuses on evaluating gut stimulation induced by the oral cholera vaccine in healthy people. The study design includes the evaluation of a probiotic lysate for its efficacy in improving the mild inflammatory response induced by the vaccine or supporting the immune response in healthy subjects.
Article
Nutrition & Dietetics
Joe Eun Son, Jay-Young Jo, San Kim, Min Ju Park, Yerin Lee, Seong Shil Park, Shin Young Park, Su Myung Jung, Sung Keun Jung, Ji Yeon Kim, Sanguine Byun
Summary: Rice bran, a by-product of rice milling, is rich in bioactive molecules and has health-promoting properties in improving metabolic conditions. This study aimed to optimize the extraction conditions of rice bran extract (RBE) and validate its impact on lipid metabolism. The optimized RBE showed significant benefits in reducing weight gain, hyperlipidemia, and hepatosteatosis in mouse models. The study also discovered that the administration of optimized RBE activated AMPK and inhibited STAT3, crucial players in liver lipid metabolism. Overall, optimized RBE holds promise as a dietary intervention against hyperlipidemia and hepatosteatosis.
Article
Nutrition & Dietetics
Seunghee Kang, Inhye Lee, Soo-yeon Park, Ji Yeon Kim, Youjin Kim, Jeong-Sook Choe, Oran Kwon
Summary: This study investigated the effects of Platycodi radix beverage (PR) on blood microbiota profiles in individuals with hyperlipidemia. It found that PR intake can improve postprandial lipid clearance in individuals with high fat intake and low fruit and vegetable intake through modulation of blood microbiota signatures.
Review
Nutrition & Dietetics
Yu Rim Kim, Min Ju Park, Soo-yeon Park, Ji Yeon Kim, Iain A. Brownlee, Amany Tawfik
Summary: Seaweed supplementation appears to be a promising strategy for improving blood glucose regulation in individuals with diabetes, as evidenced by significant improvements in postprandial blood glucose, HbA1c, and HOMA-IR levels.
Article
Biochemistry & Molecular Biology
Muniba Kousar, Yu Rim Kim, Ji Yeon Kim, Joonho Park
Summary: This study evaluated the response of Triticum aestivum to hydrogen water and trace elements treated with hydrogen water. The combined treatment of Se acid and Mo oxide showed a significant positive effect on the growth and secondary metabolites of wheat. In addition, the mixture treatment inhibited the accumulation of lipids in HepG2 hepatocytes cells. This research is important for understanding the response of plants to hydrogen water and trace elements treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yea-eun Lee, Eunok Lee, Urmi Rahman Rinik, Ji Yeon Kim, Byung Hwa Jung, Oran Kwon
Summary: This study investigated the bioavailability of six key polyphenols in Agastache rugosa (Korean mint) and found that rosmarinic acid (RA), acacetin (AC), and tilianin (TA) could be detected in human plasma after ingestion. The transport of RA occurred through the intercellular space, while AC and TA were transported through the epithelial cells. Other AC glucosides with acetyl and/or malonyl groups were rarely found in the plasma. AC glucosides with only an acetyl group appeared at the basolateral side in Caco-2 monolayers, suggesting exclusive hydrolysis of malonyl glucosides in the colon.
Review
Nutrition & Dietetics
Inhae Kang, Chai Hong Rim, Hee Sun Yang, Jeong-Sook Choe, Ji Yeon Kim, Myoungsook Lee
Summary: Isoflavone supplementation significantly affects menopausal symptoms and hormonal changes in postmenopausal women, but caution is needed in interpreting the results and further validation is required.
NUTRITION RESEARCH AND PRACTICE
(2022)