Protective Role for Antioxidants in Acute Kidney Disease

A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity

(2017) Laura Vicente-Vicente et al.   TOXICOLOGY

Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-a systematic review and network meta-analysis

(2017) Eliano P. Navarese et al.   PLoS One

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidant defenses in human blood plasma and extra-cellular fluids

(2016) Roland Stocker   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice

(2016) Imed-Eddine Kadi et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats

(2016) Reham A. El-Shafei et al.   BIOMEDICINE & PHARMACOTHERAPY

Prevention of Contrast-Induced Acute Kidney Injury: an Update

(2016) George Chalikias et al.   CARDIOVASCULAR DRUGS AND THERAPY

Allopurinol attenuates rhabdomyolysis-associated acute kidney injury: Renal and muscular protection

(2016) Pedro H.F. Gois et al.   FREE RADICAL BIOLOGY AND MEDICINE

Allopurinol Protective Effect of Renal Ischemia by Downregulating TNF-α, IL-1β, and IL-6 Response

(2016) Beatriz Prieto-Moure et al.   JOURNAL OF INVESTIGATIVE SURGERY

Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice

(2016) Yao-Bin Zhu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Signaling and stress: The redox landscape in NOS2 biology

(2015) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury

(2015) Nayara Panizo et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Investigation of the role of nitric oxide/soluble guanylyl cyclase pathway in ascorbic acid-mediated protection against acute kidney injury in rats

(2015) Vaishali Koul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of Allopurinol and Apocynin on Renal Ischemia-Reperfusion Injury in Rats

(2015) E.K. Choi et al.   TRANSPLANTATION PROCEEDINGS

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

(2015) Hongbin Tu et al.   EBioMedicine

Mitochondria-targeted therapies for acute kidney injury

(2014) Luis Carlos Tábara et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

(2014) Alpha A Fowler et al.   Journal of Translational Medicine

Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury

(2014) Zhe Wang et al.   KIDNEY INTERNATIONAL

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C Transport and Antioxidant Enzyme Function

(2013) Alexander J. Michels et al.   Annual Review of Nutrition

Evaluation of Vitamin C for Adjuvant Sepsis Therapy

(2013) John X. Wilson   ANTIOXIDANTS & REDOX SIGNALING

Role of Vitamin C in the Function of the Vascular Endothelium

(2013) James M. May et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme oxygenase-1 and acute kidney injury

(2013) Karl A. Nath   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Antioxidant therapeutics: Pandora′s box

(2013) Brian J. Day   FREE RADICAL BIOLOGY AND MEDICINE

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

(2013) Abolfazl Zarjou et al.   JOURNAL OF CLINICAL INVESTIGATION

The Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia/Reperfusion

(2013) Ramazan Altintas et al.   JOURNAL OF ENDOUROLOGY

Acute Kidney Injury and Edaravone in Acute Ischemic Stroke: The Fukuoka Stroke Registry

(2013) Masahiro Kamouchi et al.   Journal of Stroke & Cerebrovascular Diseases

Involvement of progesterone receptors in ascorbic acid–mediated protection against ischemia-reperfusion–induced acute kidney injury

(2013) Jasmine Sandhi et al.   JOURNAL OF SURGICAL RESEARCH

Does Ascorbic Acid Protect Against Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography

(2013) Umar Sadat et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies

(2013) Alan Mortensen et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

(2013) Shao-Bin Duan et al.   RENAL FAILURE

Selenium Inhibits Renal Oxidation and Inflammation But Not Acute Kidney Injury in an Animal Model of Rhabdomyolysis

(2012) Anu Shanu et al.   ANTIOXIDANTS & REDOX SIGNALING

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis

(2012) Ludwig K. Groebler et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury

(2012) Andrew M. Hall et al.   KIDNEY INTERNATIONAL

Acute kidney injury

(2012) Rinaldo Bellomo et al.   LANCET

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury

(2011) Zhen Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduction of uric acid levels with allopurinol treatment improves endothelial function in patients with chronic kidney disease

(2011) Berna Yelken et al.   CLINICAL NEPHROLOGY

Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response

(2011) Frederic T. Billings et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction

(2011) Hyun Bo Kim et al.   FREE RADICAL RESEARCH

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis

(2011) Steven G. Coca et al.   KIDNEY INTERNATIONAL

Plasma Biomarkers of Oxidant Stress and Development of Organ Failure in Severe Sepsis

(2011) Lorraine B. Ware et al.   SHOCK

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

(2011) KIYOSHI KIKUCHI et al.   Experimental and Therapeutic Medicine

The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms

(2010) Brandon J. Reeder   ANTIOXIDANTS & REDOX SIGNALING

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure

(2010) Olivier Boutaud et al.   FREE RADICAL BIOLOGY AND MEDICINE

The synthetic polyphenoltert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells

(2010) Anu Shanu et al.   FREE RADICAL RESEARCH

Nephrotoxicity From Chemotherapeutic Agents: Clinical Manifestations, Pathobiology, and Prevention/Therapy

(2010) Mark A. Perazella et al.   SEMINARS IN NEPHROLOGY

Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium

(2009) John X. Wilson   BIOFACTORS

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

(2009) Jens Lykkesfeldt et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells

(2009) Shankar Munusamy et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

(2009) Aslı Korkmaz et al.   RENAL FAILURE

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

(2008) Yolanda I. Chirino et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Antioxidants

(2008) Jay L. Koyner et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Experimental Myoglobinuric Acute Renal Failure: The Effect of Vitamin C

(2008) Sedat Ustundag et al.   RENAL FAILURE

Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion

(2007) Johannes Pleiner et al.   ATHEROSCLEROSIS

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION