Evaluation of Vitamin C for Adjuvant Sepsis Therapy

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

(2013) Daren Heyland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid

(2012) Bernard J. Fisher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

(2012) Angela Ladurner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C Inhibits Staphylococcus aureus Growth and Enhances the Inhibitory Effect of Quercetin on Growth of Escherichia coli In Vitro

(2012) Johanna Kallio et al.   PLANTA MEDICA

Compartment-specific expression of plasminogen activator inhibitor-1 correlates with severity/outcome of murine polymicrobial sepsis

(2012) Pierre Raeven et al.   THROMBOSIS RESEARCH

Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis

(2011) Gang Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Is worsening multiple organ failure the cause of death in patients with severe sepsis?*

(2011) Jean-Louis Vincent et al.   CRITICAL CARE MEDICINE

Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury*

(2011) Bernard J. Fisher et al.   CRITICAL CARE MEDICINE

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Bactericidal antibiotics temporarily increase inflammation and worsen acute kidney injury in experimental sepsis*

(2011) Zhi-Yong Peng et al.   CRITICAL CARE MEDICINE

Vascular Dysfunction in Sepsis

(2011) Nicolás Nin et al.   SHOCK

Selective Ascorbate Toxicity in Malignant Mesothelioma

(2010) Elia Ranzato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nitric oxide mediates tightening of the endothelial barrier by ascorbic acid

(2010) James M. May et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

H2O2-mediated Cytotoxicity of Pharmacologic Ascorbate Concentrations to Neuroblastoma Cells: Potential Role of Lactate and Ferritin

(2010) Beate Deubzer et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries

(2010) Dan Secor et al.   INTENSIVE CARE MEDICINE

Endotoxin Conditioning Induces VCP/p97-mediated and Inducible Nitric-oxide Synthase-dependent Tyr284Nitration in Protein Phosphatase 2A

(2010) Takashi Ohama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamin C supplementation in patients receiving peripheral parenteral nutrition after gastrointestinal surgery

(2010) Eriko Yamazaki et al.   NUTRITION

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

(2010) Sebastian J. Padayatty et al.   PLoS One

Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation

(2009) Feng Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism*

(2009) Karel Tyml et al.   CRITICAL CARE MEDICINE

Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A

(2009) Min Han et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intra-abdominal Sepsis: Newer Interventional and Antimicrobial Therapies

(2009) Joseph S. Solomkin et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Oxalic acid excretion after intravenous ascorbic acid administration

(2009) Line Robitaille et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction

(2008) F. Wu et al.   CARDIOVASCULAR RESEARCH

Ferritin iron content in haemodialysis patients: Comparison with septic and hemochromatosis patients

(2008) P.L. Spada et al.   CLINICAL BIOCHEMISTRY

iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells

(2008) Feng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impact of High-Dose Antioxidants on Outcomes in Acutely Injured Patients

(2008) Bryan R. Collier et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL